Human trophoblast cells express the immunomodulator progesterone-induced blocking factor

Progesterone-induced blocking factor is hormonally regulated in human astrocytoma cells, and increases their growth through the IL-4R/JAK1/STAT6 pathway

“…PIBF was found to exist in several forms: the full-length PIBF mRNA encoding a 90 kD protein with a nuclear localization and other spliced species (35, 57, and 60 kDa) that have a cytoplasmic location [2]. PIBF expression was shown in proliferating cells such as human trophoblasts [3], mesenchymal stem cells [4] and solid malignant tumors [2]. Tumor cell lines derived from various biopsies of breast cancer over-express PIBF at mRNA level [2].…”

Progesterone-induced blocking factor differentially regulates trophoblast and tumor invasion by altering matrix metalloproteinase activity

“…Within the first trimester decidua, the expression pattern of PIBF coincides with sites of trophoblast invasion and the most intense PIBF-staining appears at the extravillous trophoblast [10]. Early detection of PIBF may be related to premature trophoblast invasion possibly into an endometrium not yet prepared for the trophoblast and might lead to early immune rejection of the fetus [11].…”

“…Recently it was shown that PIBF is up-regulated in undifferentiated proliferating cells (e.g, trophoblast cells) as well as in a set of malignancies [10][11][12][13][14]. Several breast cancers overexpress PIBF compared to normal breast tissues [12]; moreover, MCF-7 breast carcinoma cells produce PIBF independently of progesterone [12].…”

Le trophoblaste : chef d’orchestre de la tolérance immunologique maternelle

“…Le trophoblaste villeux sécrètent la protéine PIBF qui joue un rôle important dans le déroulement de la grossesse en étant un intermédiaire des effets de la progestérone [89]. PIBF diminue la production de cytokines Th1 et augmente celle des cytokines Th2, inhibe la cytotoxicité des cellules NK et l'activité de la phospholipase A2 (PLA2 phospholipase A2) [90].…”