Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Skin Aging of Nude Mice Through Autophagy-Mediated Anti-Senescent Mechanism

MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model

“…Zhang et al found that BMMSCs promote anti-inflammatory polarization of macrophages and produce low levels of ROS via exosomal delivery of miR-16 and miR-21 to attenuate SLE nephritis in lupus mice [ 58 ]. Similarly, it has been reported that hucMSCs significantly reverse senescence in HDFs by inhibiting ROS production and restoring the overexpression of oxidative and senescence markers through a paracrine effect [ 59 ]. Therefore, blocking excess ROS levels to alleviate oxidative stress is a promising strategy to reduce lung inflammation.…”

Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

“…This may be due to different models. It is well known that aging increases the level of oxidative stress in the wound and thus disrupts the regenerative microenvironment [ 74 ]. Therefore, reducing oxidative stress is beneficial for wound healing [ 75 ], which provides a better tissue environment for HFSCs regeneration.…”

Human placenta‐derived mesenchymal stem cells ameliorate diabetic kidney disease by modulating the T helper 17 cell/ regulatory T‐cell balance through the programmed death 1 / programmed death‐ligand 1 pathway

“…These results indicate that MSC‐derived exosomes may be a promising therapeutic cell‐free strategy for DKD. Additionally, the latest study showed that MSCs protect kidney injury in diabetic rats through an autophagy‐mediated antisenescent mechanism 32 . Our results showed that PMSCs mainly homed to immune organs rather than the injured pancreas and kidney, and Th17/Treg cells were observed in the spleen and rarely observed in the kidney, indicating that the therapeutic effects of PMSCs can be largely attributed to their immunomodulatory properties and the spleen played a critical role in amplifying the MSC‐mediated immunomodulatory effects 33 .…”