Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3 + CD4 + T cells

Mohammadzadeh, Adel; Lahouty, Masoud; charkhian, Hamed; Ghafour, Arash Adamnejad; Moazzendizaji, Sahand; rezaei, Jafar; alipour, Shahriar; Irannejad, Vahid Shafiei; Ansari, Mohammad Hassan Khadem

doi:10.1007/s11033-024-09433-5

Mol Biol Rep

2024

DOI: 10.1007/s11033-024-09433-5

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Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3 + CD4 + T cells

Adel Mohammadzadeh,

Masoud Lahouty,

Hamed charkhian

et al.

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The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions

Lee,

Park,

Jung

et al. 2024

Biomedicines

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Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused by cerebellar dysfunction. The absence of treatments approved by the U.S. Food and Drug Administration for SCA has driven the investigation of alternative therapeutic strategies, including stem cell therapy. Mesenchymal stem cells (MSCs), known for their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, and modulate brain inflammation. Recent findings from preclinical and clinical studies are also reviewed, emphasizing the promise of MSC therapy in addressing the unmet needs of SCA patients. Furthermore, ongoing clinical trials and future directions are proposed to address the limitations of the current approaches.

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The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions

Lee,

Park,

Jung

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Human umbilical cord mesenchymal stem cell-derived exosomes alleviate the severity of experimental autoimmune encephalomyelitis and enhance lag-3 expression on foxp3 + CD4 + T cells

Cited by 1 publication

References 43 publications

The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions

The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions

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