Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer?

ArefNezhad, Reza; Rezaei-Tazangi, Fatemeh; Roghani‐Shahraki, Hossein; Goleij, Pouya; Zare, Nabi; Motedayyen, Hossein; Aghazadeh, Elaheh

doi:10.1002/cbin.11991

Cited by 6 publications

(2 citation statements)

References 64 publications

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“…Immunotherapy seeks to utilize the immune system in the management of a diverse range of illnesses ( 1 – 4 ). Nonetheless, in order for a particular therapy to be efficacious, it is essential that it precisely target an immune response against the illness while simultaneously safeguarding the host from autoimmunity and producing the desired antitumor outcomes ( 5 – 7 ). Such an effect is scrutinized especially in the context of cancer and autoimmune disorders ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Regulating the regulatory T cells as cell therapies in autoimmunity and cancer

Hosseinalizadeh,

Rabiee,

Eghbalifard

et al. 2023

Front. Med.

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Regulatory T cells (Tregs), possess a pivotal function in the maintenance of immune homeostasis. The dysregulated activity of Tregs has been associated with the onset of autoimmune diseases and cancer. Hence, Tregs are promising targets for interventions aimed at steering the immune response toward the desired path, either by augmenting the immune system to eliminate infected and cancerous cells or by dampening it to curtail the damage to self-tissues in autoimmune disorders. The activation of Tregs has been observed to have a potent immunosuppressive effect against T cells that respond to self-antigens, thus safeguarding our body against autoimmunity. Therefore, promoting Treg cell stability presents a promising strategy for preventing or managing chronic inflammation that results from various autoimmune diseases. On the other hand, Tregs have been found to be overactivated in several forms of cancer, and their role as immune response regulators with immunosuppressive properties poses a significant impediment to the successful implementation of cancer immunotherapy. However, the targeting of Tregs in a systemic manner may lead to the onset of severe inflammation and autoimmune toxicity. It is imperative to develop more selective methods for targeting the function of Tregs in tumors. In this review, our objective is to elucidate the function of Tregs in tumors and autoimmunity while also delving into numerous therapeutic strategies for reprogramming their function. Our focus is on reprogramming Tregs in a highly activated phenotype driven by the activation of key surface receptors and metabolic reprogramming. Furthermore, we examine Treg-based therapies in autoimmunity, with a specific emphasis on Chimeric Antigen Receptor (CAR)-Treg therapy and T-cell receptor (TCR)-Treg therapy. Finally, we discuss key challenges and the future steps in reprogramming Tregs that could lead to the development of novel and effective cancer immunotherapies.

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Section: Introductionmentioning

confidence: 99%

Regulating the regulatory T cells as cell therapies in autoimmunity and cancer

Hosseinalizadeh,

Rabiee,

Eghbalifard

et al. 2023

Front. Med.

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“…Its etiology is largely related to genetic, immunological, and environmental factors. Defects in immune responses, cell apoptosis, and DNA repair functions have fundamental role in its development and progression (2,3). Oncogenes, as important genes involved in cell cycle regulation and apoptosis, can undergo genetic or epigenetically driven alterations that lead to cancer (4,5).…”

Section: Introduction Cancer and Tumorigenesismentioning

confidence: 99%

Plant-based anticancer compounds with a focus on breast cancer

Hasan-Abad,

Sobhani-Nasab,

Atapour

et al. 2023

Preprint

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Cancer as a terrible disease ranks among the most important healthcare issues confronting humanity, necessitating a proactive approach to treatment. Numerous signaling cascades are involved in the complex process of carcinogenesis. Despite its success, chemotherapy has had some undesirable side effects. Plants offer a rich source of novel substances and represent an exciting new option for cancer research. Plants and plant-derived products are revolutionizing themselves because they are less poisonous, quicker, cheaper, safer, and simpler than standard treatment procedures. Natural products are viewed as viable candidates for the creation of anticancer medicines because of their pleiotropic effects on target events in a variety of ways. The actions of plant-derived products are selective; they damage cancer cells and have no significant effect on healthy cells. Several researches are being conducted on the production of potential candidates from these plant-derived products that can stop or inhibit cancer cell proliferation without causing adverse effects. Numerous plant-derived products and the analogs from which they were derived have been identified as potential anticancer therapeutic possibilities. In this review, we summarize research on botanical products with significant and active anticancer activity and their anticancer constituents, with a focus on breast cancer. This review sought to highlight the most recent advances and key successes in plant-derived products and cancer therapies focusing on nuclear and cellular structures. Furthermore, cancer drugs and their problems are discussed.

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Plant‐Based Anticancer Compounds With a Focus on Breast Cancer

Hasan‐Abad,

Atapour,

Sobhani‐Nasab

et al. 2024

Cancer Reports

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Breast cancer is a common form of cancer among women characterized by the growth of malignant cells in the breast tissue. The most common treatments for this condition include chemotherapy, surgical intervention, radiation therapy, hormone therapy, and biological therapy. The primary issues associated with chemotherapy and radiation therapy are their adverse events and significant financial burden among patients in underdeveloped countries. This highlights the need to explore and develop superior therapeutic options that are less detrimental and more economically efficient. Plants provide an abundant supply of innovative compounds and present a promising new avenue for investigating cancer. Plants and their derivations are undergoing a revolution due to their reduced toxicity, expediency, cost‐effectiveness, safety, and simplicity in comparison to conventional treatment methods. Natural products are considered promising candidates for the development of anticancer drugs, due perhaps to the diverse pleiotropic effects on target events. The effects of plant‐derived products are limited to cancer cells while leaving healthy cells unaffected. Identification of compounds with strong anticancer properties and development of plant‐based medications for cancer treatment might be crucial steps in breast cancer therapy. Although bioactive compounds have potent anticancer properties, they also have drawbacks that need to be resolved before their application in clinical trials and improved for the approved drugs. This study aims to give comprehensive information on known anticancer compounds, including their sources and molecular mechanisms of actions, along with opportunities and challenges in plant‐based anticancer therapies.

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Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer?

Cited by 6 publications

References 64 publications

Regulating the regulatory T cells as cell therapies in autoimmunity and cancer

Regulating the regulatory T cells as cell therapies in autoimmunity and cancer

Plant-based anticancer compounds with a focus on breast cancer

Plant‐Based Anticancer Compounds With a Focus on Breast Cancer

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