Human umbilical cord mesenchymal stem cell-derived exosomes provide neuroprotection in traumatic brain injury through the lncRNA TUBB6/Nrf2 pathway

Zhang, Li; Bai, Wanshan; Peng, Yaonan; Lin, Yixing; Tian, Mi

doi:10.1016/j.brainres.2023.148689

Cited by 10 publications

(2 citation statements)

References 47 publications

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“…Furthermore, HucMSC-Exo suppresses ferroptosis-related markers such as ACSL4, and their modulation of the Nrf2 signaling pathway significantly contributes to alleviating oxidative damage and inflammation associated with TBI. These findings underscore the therapeutic potential of HUCMSC-Exo in managing TBI-related neurological complications ( Zhang L. et al, 2024 ).…”

Section: Nrf2/ho-1 Regulation In Human Diseasesmentioning

confidence: 60%

Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Su,

Wang,

Zhou

et al. 2024

Front. Cell Dev. Biol.

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This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on the integumentary, respiratory, cardiovascular, urinary, and skeletal systems, the study highlights the versatility of MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge as central mediators of their antioxidative and anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung injuries, and even offering solutions for conditions like myocardial infarction and renal ischemia-reperfusion injury, MSC-EVs demonstrate promising therapeutic efficacy. Their adaptability to different administration routes and identifying specific factors opens avenues for innovative regenerative strategies. This review positions MSC-EVs as promising candidates for future clinical applications, providing a comprehensive overview of their potential impact on regenerative medicine.

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Section: Nrf2/ho-1 Regulation In Human Diseasesmentioning

confidence: 60%

Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Su,

Wang,

Zhou

et al. 2024

Front. Cell Dev. Biol.

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“…Exosomes from HucMSCs provide neuroprotection against TBIs by activating the lncRNA TUBB6/Nrf2 pathway, reducing inflammation and ferroptosis. Knocking down TUBB6 partially diminishes their neuroprotective effect, highlighting their importance [130]. Further research is required to determine whether their non-coding RNAs contribute to this effect and if adjusting the timing of exosome administration can enhance their neuroprotection against TBIs.…”

Section: Regenerative Medicinementioning

confidence: 99%

Innovative Insights into Traumatic Brain Injuries: Biomarkers and New Pharmacological Targets

Silvestro,

Raffaele,

Quartarone

et al. 2024

IJMS

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A traumatic brain injury (TBI) is a major health issue affecting many people across the world, causing significant morbidity and mortality. TBIs often have long-lasting effects, disrupting daily life and functionality. They cause two types of damage to the brain: primary and secondary. Secondary damage is particularly critical as it involves complex processes unfolding after the initial injury. These processes can lead to cell damage and death in the brain. Understanding how these processes damage the brain is crucial for finding new treatments. This review examines a wide range of literature from 2021 to 2023, focusing on biomarkers and molecular mechanisms in TBIs to pinpoint therapeutic advancements. Baseline levels of biomarkers, including neurofilament light chain (NF-L), ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), Tau, and glial fibrillary acidic protein (GFAP) in TBI, have demonstrated prognostic value for cognitive outcomes, laying the groundwork for personalized treatment strategies. In terms of pharmacological progress, the most promising approaches currently target neuroinflammation, oxidative stress, and apoptotic mechanisms. Agents that can modulate these pathways offer the potential to reduce a TBI’s impact and aid in neurological rehabilitation. Future research is poised to refine these therapeutic approaches, potentially revolutionizing TBI treatment.

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Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury

Tang,

Xu,

Zhao

et al. 2025

Clinical Neurology and Neurosurgery

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Human umbilical cord mesenchymal stem cell-derived exosomes provide neuroprotection in traumatic brain injury through the lncRNA TUBB6/Nrf2 pathway

Cited by 10 publications

References 47 publications

Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Innovative Insights into Traumatic Brain Injuries: Biomarkers and New Pharmacological Targets

Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury

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