Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production

Rossato, Marco; Granzotto, Marnie; Macchi, Veronica; Porzionato, Andrea; Petrelli, Lucía; Calcagno, Alessandra; Vencato, J.; Stefani, Diego De; Silvestrin, Valentina; Meneghesso, Gaudenzio; Bassetto, Franco; De, Raffaele; Vettor, Roberto

doi:10.1016/j.mce.2013.12.005

Cited by 101 publications

(126 citation statements)

References 50 publications

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“…Interestingly, the obesity effects on IL-4 and UCP1 expression are modulated by the CB2 Q63R functional variant, resulting to be attenuated in ADPs derived from QQ obese subjects and exacerbated in ADPs from RR patients. Of course, to strengthen this first evidence of a browning effect mediated by CB2 receptor stimulation, it could be very interesting to demonstrate the induction of the thermogenesis process in cultured adipocytes after treatment with the CB2 agonist JWH-133 (42) .…”

Section: Differential Functioning Of Cb2 Has Been Demonstrated In Relmentioning

confidence: 93%

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

Rossi¹,

Bellini

Luongo

et al. 2016

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Differential Functioning Of Cb2 Has Been Demonstrated In Relmentioning

confidence: 93%

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

Rossi¹,

Bellini

Luongo

et al. 2016

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…117) TRPM8 was also expressed in a human white adipocyte cell line, in which TRPM8 activation by menthol or icilin induced UCP1 expression, mitochondrial activation, and heat production. 118) In addition, mRNA and expression levels of TRPM8 protein were significantly increased during adipocyte differentiation, suggesting the importance of TRPM8 for adipocyte thermogenesis. 118) On the other hand, it has been reported that menthol treatment on the skin or cold exposure causes a TRPM8-dependent increase in core body temperature, which might be related to an increase in UCP1 expression.…”

Section: )mentioning

confidence: 97%

“…118) In addition, mRNA and expression levels of TRPM8 protein were significantly increased during adipocyte differentiation, suggesting the importance of TRPM8 for adipocyte thermogenesis. 118) On the other hand, it has been reported that menthol treatment on the skin or cold exposure causes a TRPM8-dependent increase in core body temperature, which might be related to an increase in UCP1 expression. 119) Intragastric administration of menthol enhanced BAT thermogenesis and browning of WAT in mice.…”

Section: )mentioning

confidence: 97%

Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue

Uchida

Sun

Yamazaki

et al. 2018

Biological & Pharmaceutical Bulletin

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Brown and beige adipocytes are a major site of mammalian non-shivering thermogenesis and energy dissipation. Obesity is caused by an imbalance between energy intake and expenditure and has become a worldwide health problem. Therefore modulation of thermogenesis in brown and beige adipocytes could be an important application for body weight control and obesity prevention. Over the last few decades, the involvement of thermo-sensitive transient receptor potential (TRP) channels (including TRPV1, TRPV2, TRPV3, TRPV4, TRPM4, TRPM8, TRPC5, and TRPA1) in energy metabolism and adipogenesis in adipocytes has been extensively explored. In this review, we summarize the expression, function, and pathological/ physiological contributions of these TRP channels and discuss their potential as future therapeutic targets for preventing and combating human obesity and obesity-related metabolic disorders.

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“…34 Human adipocytes also express transient receptor potential melastin-8, and transient receptor potential melastin-8 activation in these cells in vitro induces UCP1 expression. 35 Conversely, other ion channels appear to have a role in repressing BAT activity, evidenced by the fact that inhibition of these channels leads to BAT activation. Among these are the transient receptor potential vanilloid-4 channel 36 and the voltagegated potassium channel Kv1.3, 37 whose pharmacological inhibition promotes the browning of WAT and the activation of existing BAT, respectively.…”

Section: Modulation Of Ion Channels Activity: An Emerging Pathway Of mentioning

confidence: 99%

Non-sympathetic control of brown adipose tissue

Cereijo

Villarroya

2015

Int J Obes Supp

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The thermogenic activity of brown adipose tissue (BAT) in the organism is tightly regulated through different processes, from short-term induction of uncoupling protein-1-mediated mitochondrial proton conductance to complex processes of BAT recruitment, and appearance of the beige/brite adipocytes in white adipose tissue (WAT), the so-called browning process. The sympathetic nervous system is classically recognized as the main mediator of BAT activation. However, novel factors capable of activating BAT through non-sympathetic mechanisms have been recently identified. Among them are members of the bone morphogenetic protein family, with likely autocrine actions, and activators of nuclear hormone receptors, especially vitamin A derivatives. Multiple endocrine factors released by peripheral tissues that act on BAT have also been identified. Some are natriuretic peptides of cardiac origin, whereas others include irisin, originating in skeletal muscle, and fibroblast growth factor-21, mainly produced in the liver. These factors have cell-autonomous effects in brown adipocytes, but indirect effects in vivo that modulate sympathetic activity toward BAT cannot be excluded. Moreover, these factors can affect to different extents such as the activation of existing BAT, the induction of browning in WAT or both. The identification of non-sympathetic controllers of BAT activity is of special biomedical interest as a prerequisite for developing pharmacological tools that influence BAT activity without the side effects of sympathomimetics.

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Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production

Cited by 101 publications

References 50 publications

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation

Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue

Non-sympathetic control of brown adipose tissue

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