Human Wound and Its Burden: Updated 2022 Compendium of Estimates

Sen, Chandan K.

doi:10.1089/wound.2023.0150

Cited by 56 publications

(17 citation statements)

References 86 publications

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“…Chronic wounds impose a significant and growing burden on the quality of life of patients, on healthcare expenditures, and on lost productivity worldwide. 1 Given their constant exposure to external environmental elements, skin wounds are prone to chronic and recurrent colonisation with bacteria. High bacterial loads in chronic wounds stall healing 2,3 and increase the risk of infection and complications such as sepsis.…”

Section: Introductionmentioning

confidence: 99%

An objective comparative study of non‐surgical cleansing techniques and cleanser types in bacterial burden management

Oropallo,

Rao,

Del Pin

et al. 2024

International Wound Journal

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Cleansing is a vital component of effective wound hygiene and biofilm management, often accomplished through vigorous mechanical action or through soaking with moistened gauze. In the present study, a quantitative comparison of the effectiveness of different cleansing techniques and solutions in removing bacteria was conducted on 71 chronic wounds using bacterial fluorescence imaging as a real‐time diagnostic for moderate to high bacterial loads. Vigorous gauze cleansing for 30 s proved most effective by reducing bacterial fluorescence by 33.99%, surpassing 10‐min soaking in bacterial reduction (13.24%). Among different cleansers, no statistically significant differences in effectiveness were observed, but povidone‐iodine showed the strongest trend towards bacterial reduction. Sub‐analysis highlighted the superiority of antiseptic cleansers over saline and gentle soap (−33.30% vs. −1.80% bacterial reduction respectively). Five percent acetic acid was also shown to be more effective in removing specific bacterial strains (Pseudomonas aeruginosa). Findings from studies like this contribute to refining wound hygiene guidelines and clinical algorithms for bacterial and biofilm management.

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Section: Introductionmentioning

confidence: 99%

An objective comparative study of non‐surgical cleansing techniques and cleanser types in bacterial burden management

Oropallo,

Rao,

Del Pin

et al. 2024

International Wound Journal

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“…Failure in epithelialization contributes to various chronic nonhealing wounds, such as venous ulcer (VU) and diabetic foot ulcer (DFU). Chronic wounds affect approximately 2% of the population, imposing an annual cost of USD 20 billion and presenting a substantial and rising health and economic burden ( 5 ). Because of the complex pathophysiology of chronic wounds, few targeted therapeutic drugs have been developed.…”

Section: Introductionmentioning

confidence: 99%

Single-cell profiling and functional screening reveal crucial roles for lncRNAs in the epidermal re-epithelialization of human acute wounds

Xiao,

Zhang,

Liu

et al. 2024

Front. Surg.

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ObjectivesRe-epithelialization is an important physiological process for repairing skin barrier function during wound healing. It is primarily mediated by coordinated migration, proliferation, and differentiation of keratinocytes. Long noncoding RNAs (lncRNAs) are essential components of the noncoding genome and participate in various biological processes; however, their expression profiles and function in re-epithelialization during wound healing have not been established.MethodsWe investigated the distribution of lncRNAs during wound re-epithelialization by comparing the genomic profiles of uninjured skin and acute wound (AW) from healthy donors. We performed functional screening of differentially expressed lncRNAs to identify the important lncRNAs for re-epithelialization.ResultsThe expression of multiple lncRNAs is changed during human wound re-epithelialization process. We identified VIM-AS1, SMAD5-AS1, and LINC02581 as critical regulators involved in keratinocyte migration, proliferation, and differentiation, respectively.ConclusionLncRNAs play crucial regulatory roles in wound re-epithelialization. We established lncRNA expression profile in human acute wounds compared with intact skin, offering valuable insights into the physiological mechanisms underlying wound healing and potential therapeutic targets.

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“…[4] Chronic wounds emerge as a critical healthcare concern, affecting 10.5 million U.S. Medicare beneficiaries and ≈2.5% of the total population, especially burdening the elderly in the context of prevalent issues such as diabetes and obesity, accompanied by persistent infection challenges. [5] Recent research, exemplified by a prospective cohort study, underscores the widespread impact of obesity on the risk of surgical site infections, emphasizing the imperative for tailored strategies in various healthcare settings. [6] Furthermore, investigations indicated that the complications in surgical wound healing, observed in 3% to 12% of obese women post-cesarean delivery, underscore the ubiquity of these challenges across diverse healthcare environments.…”

Section: Introductionmentioning

confidence: 99%

“…Mean fluorescence intensityof sample Mean fluorescence intensityof unstained sample (5) In Vitro Scratch Wound Assay: The ability of caffeine-reinforced collagen bio-matrix to promote cell migration was studied using in vitro scratch wound assay on S3T6 fibroblast cells. [20] Approximately 50000 cells were seeded in 24 well plates pre-coated with control and reinforced collagen bio-matrices and grown until confluence.…”

mentioning

confidence: 99%

Caffeine‐reinforced Collagen as Localized Microenvironmental Trans‐Browning Bio‐Matrix for Soft Tissue Repair and Regeneration in Bariatric Condition

Sreekumar,

Vijayan,

Gangaraj

et al. 2023

Advanced Biology

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The wound exudates, hypoperfusion of the subcutaneous fat layer, and poor vasculature worsen wound management in obese subjects. In the current study, a multifunctional Caffeine‐reinforced collagen biomaterial is developed that can simultaneously modulate lipid metabolism and angiogenesis in obese wound microenvironments for faster tissue regeneration. The biomaterial is fabricated specialized for obese conditions to initiate simultaneous lipolysis and angiogenesis locally in the hypoxic subcutaneous fat in wound margins of obese subjects. Caffeine‐reinforced collagen biomatrix shows better structural integrity, thermal stability, bio‐compatibility, and lesser proteolytic susceptibility. Caffeine‐collagen biomaterial promote angiogenesis, fibroblast migration, and localized browning of white adipocytes to activate thermogenesis in the subcutaneous fat layer at the wound site. Full‐thickness excision wound healing studies performed in obese C57BL6 mice shows faster wound closure within day 9 when compare to control mice. The Caffeine‐reinforced collagen biomaterial remodeled the wound site locally by activating fibroblast to secrete collagen, activate endothelial cells to promote angiogenesis, and induce browning in white adipocytes in subcutaneous fat. The study opens a new direction in bariatric tissue regenerative medicine by locally modulating lipid metabolism, angiogenesis, and trans‐browning at the injured site for faster complete restoration of the damaged tissue.

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Human Wound and Its Burden: Updated 2022 Compendium of Estimates

Cited by 56 publications

References 86 publications

An objective comparative study of non‐surgical cleansing techniques and cleanser types in bacterial burden management

An objective comparative study of non‐surgical cleansing techniques and cleanser types in bacterial burden management

Single-cell profiling and functional screening reveal crucial roles for lncRNAs in the epidermal re-epithelialization of human acute wounds

Caffeine‐reinforced Collagen as Localized Microenvironmental Trans‐Browning Bio‐Matrix for Soft Tissue Repair and Regeneration in Bariatric Condition

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