Human β-defensin 1 update: Potential clinical applications of the restless warrior

Álvarez, Ángel H.; Martínez-Velázquez, Moisés; de, Ernesto Prado Montes

doi:10.1016/j.biocel.2018.09.007

Cited by 41 publications

(22 citation statements)

References 37 publications

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“…Another highly upregulated antimicrobial peptide, DEFB1 ( Supplementary Table 2 ), belongs to a family of cytotoxic peptides made by neutrophils. This gene has recently been identified as a chromosome 8p tumor-suppressor gene, downregulated in several malignancies such as salivary gland tumors, oral squamous cell carcinoma, and colon and liver cancer ( Álvarez et al, 2018 ; Sun et al, 2019 ). Loss of orthologous murine defense-1 in mice enhances nickel sulfate-induced uLMS and causes mouse kidney cells to exhibit increased susceptibility to HPV-16 E6/7-induced neoplastic transformation ( Sun et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…Loss of orthologous murine defense-1 in mice enhances nickel sulfate-induced uLMS and causes mouse kidney cells to exhibit increased susceptibility to HPV-16 E6/7-induced neoplastic transformation ( Sun et al, 2019 ). DEFB1 also induces formation of neutrophil extracellular traps (NETs) ( Álvarez et al, 2018 ), mesh-like structures composed of cytosolic and granule proteins which are assembled on a scaffold of decondensed chromatin fibers in a process termed NETosis, which has been proposed to protect tumor cells from T cell- or natural killer (NK) cell-mediated toxicity ( Teijeira et al, 2020 ). This should be further studied by developing a specific antibody panel to visualize and measure NET formation in tissue.…”

Section: Discussionmentioning

confidence: 99%

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Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma

Sanegre

Eritja

Andrea

et al. 2021

Front. Cell Dev. Biol.

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The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma

Sanegre

Eritja

Andrea

et al. 2021

Front. Cell Dev. Biol.

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“…This is in favor of the point that CCL8 in melanoma might play a protective role overall, of which the mechanism warrants further investigation. DEFB1 is a peptide with multiple immune-related functions and is thought to be a tumor suppressor 44,45 . It was found to be downregulated in renal, prostate and colorectal cancers 46,47 .…”

Section: Discussionmentioning

confidence: 99%

“…DEFB1 is a peptide with multiple immune-related functions and is thought to be a tumor suppressor 44 , 45 . It was found to be downregulated in renal, prostate and colorectal cancers 46 , 47 .…”

Section: Discussionmentioning

confidence: 99%

A novel predictive model incorporating immune-related gene signatures for overall survival in melanoma patients

Liao

Zeng

Yao

et al. 2020

Sci Rep

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Melanoma is the most invasive type of skin cancer, in which the immune system plays a vital role. In this study, we aimed to establish a prognostic prediction nomogram for melanoma patients that incorporates immune-related genes (IRGs). Ninety-seven differentially expressed IRGs between melanoma and normal skin were screened using gene expression omnibus database (GEO). Among these IRGs, a two-gene signature consisting of CCL8 and DEFB1 was found to be closely associated with patient prognosis using the cancer genome atlas (TCGA) database. Survival analysis verified that the IRGs score based on the signature gene expressions efficiently distinguished between high-and low-risk patients, and was identified to be an independent prognostic factor. A nomogram integrating the IRGs score, age and TNM stage was established to predict individual prognosis for melanoma. The prognostic performance was validated by the TCGA/GEO-based concordance indices and calibration plots. The area under the curve demonstrated that the nomogram was superior than the conventional staging system, which was confirmed by the decision curve analysis. Overall, we developed and validated a nomogram for prognosis prediction in melanoma based on IRGs signatures and clinical parameters, which could be valuable for decision making in the clinic. Abbreviations PD-1 Programmed death-1 CLTA-4 Cytotoxic T-lymphocyte antigen 4 GEO Gene expression omnibus TCGA The cancer genome atlas DEGs Differentially expressed genes IRGs Immune-related genes DE-IRGs Differentially expressed immune-related genes KEGG Kyoto encyclopedia of genes and genomes GO Gene ontology PPI Protein-protein interactions LASSO Least absolute shrinkage and selection operator OS Overall survival GEPIA Gene expression profiling interactive analysis ROC Receiver operating characteristic AUC Area under the curve DCA Decision curve analysis HR Hazard ratio

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“…Human α-defensin generally damages bacteria by disrupting cell membranes, while HD-6 defends against pathogenic bacteria by trapping microbes in the intestinal lumen (Chairatana and Nolan, 2017). Human βdefensin can also mediate membrane lysis to exert antimicrobial activity, as well as capture or kill bacteria by inducing self-nets and neutrophil extracellular traps (NETs) (Alvarez et al, 2018). In addition, cathelicidin can mediate membrane perturbation and induce ROS production to inhibit bacterial growth (Rowe-Magnus et al, 2019).…”

Section: Bioactive Metabolites-depended Crosstalk Between Gut Microbimentioning

confidence: 99%

Crosstalks Between Gut Microbiota and Vibrio Cholerae

Qin

Yang

Chen

et al. 2020

Front. Cell. Infect. Microbiol.

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Vibrio cholerae, the causative agent of cholera, could proliferate in aquatic environment and infect humans through contaminated food and water. Enormous microorganisms residing in human gastrointestinal tract establish a special microecological system, which immediately responds to the invasion of V. cholerae, through "colonization resistance" mechanisms, such as antimicrobial peptide production, nutrients competition, and intestinal barrier maintenances. Meanwhile, V. cholerae could quickly sense those signals and modulate the expression of relevant genes to circumvent those stresses during infection, leading to successful colonization on the surface of small intestinal epithelial cells. In this review, we summarized the crosstalks profiles between gut microbiota and V. cholerae in the terms of Type VI Secretion System (T6SS), Quorum Sensing (QS), Reactive Oxygen Species (ROS)/pH stress, and Bioactive metabolites. These mechanisms can also be applied to molecular bacterial pathogenesis of other pathogens in host.

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Human β-defensin 1 update: Potential clinical applications of the restless warrior

Cited by 41 publications

References 37 publications

Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma

Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma

A novel predictive model incorporating immune-related gene signatures for overall survival in melanoma patients

Crosstalks Between Gut Microbiota and Vibrio Cholerae

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