2011
DOI: 10.1016/j.atherosclerosis.2011.06.038
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Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice

Abstract: Objective Humanin (HN) is a cytoprotective peptide derived from endogenous mitochondria, expressed in the endothelial layer of human vessels, but its role in atherogenesis in vivo is not known. In vitro study, however, HN reduced oxidized low-density lipoprotein induced formation of reactive oxygen species and apoptosis. The present study tested the hypothesis that long term treatment with HN will have a protective role against endothelial dysfunction and progression of atherosclerosis in vivo. Methods and r… Show more

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Cited by 96 publications
(81 citation statements)
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“…However, one benefit of this method is that arterial samples reach the coronary circulation first, perhaps furthering its endothelial protective role. These findings are supported by previous animal work in our lab showing that endothelial function can be preserved with the long term administration of humanin without concomitant alterations in other traditional molecular surrogates for vascular health such as VEGF, insulin, resistin, tPAI-1, or IL-6 (22). Along these lines, we found that L-arginine levels were not allied with humanin levels, arguing against, but not completely discounting, a link between NO bioavailability and humanin levels and administration (29).…”
Section: Discussionsupporting
confidence: 85%
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“…However, one benefit of this method is that arterial samples reach the coronary circulation first, perhaps furthering its endothelial protective role. These findings are supported by previous animal work in our lab showing that endothelial function can be preserved with the long term administration of humanin without concomitant alterations in other traditional molecular surrogates for vascular health such as VEGF, insulin, resistin, tPAI-1, or IL-6 (22). Along these lines, we found that L-arginine levels were not allied with humanin levels, arguing against, but not completely discounting, a link between NO bioavailability and humanin levels and administration (29).…”
Section: Discussionsupporting
confidence: 85%
“…In vivo work from our group also demonstrated that humanin administration preserves endothelial function and reduces atheromatous plaque burden in ApoE knockout mice (22). These effects are believed to be achieved through improved nitric oxide (NO) bioavailability (22), regulation of anti-apoptotic factors (19), and AMP-kinase signaling (21). Recent work has also shown that humanin attenuates remodeling of the renal vasculature in a murine model of atherosclerosis mainly by downregulating proteins involved in angiogenesis, apoptosis, fibrosis, and inflammation (30).…”
mentioning
confidence: 82%
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“…Humanin has also been shown to increase insulin sensitivity in the peripheral tissues via STAT3-mediated activation of the central nervous system (26) and preserve endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic apolipoprotein E-deficient mice (27).…”
Section: Humanin Is a Secreted Bioactive Peptide That Suppresses Cellmentioning
confidence: 99%