Hyalinizing clear cell carcinoma: A case report and review of the literature

Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature

“…The most difficult differential diagnosis is CCEOT versus clear cell odontogenic carcinoma (CCOC)/(hyalinizing) clear cell carcinoma (CCC). The distinction from CCOC/CCC is of paramount importance, since CCOCs and CCCs can be clinically aggressive with loco-regional recurrences and metastases to regional lymph nodes and distant sites [22,23]. This is in contrast to CCEOTs which tend to have an excellent prognosis when adequately excised [7].…”

Envisioning the Next WHO Head and Neck Classification

“…Accumulated experience bears out that HCCC is generally a low-grade malignancy with predilection for intraoral sites, most often palate and tongue base; origin from major salivary glands or extraoral minor salivary sites is very rare [36,37]. Histologically, HCCC commonly elaborates hyalinized matrix and elicits a desmoplastic response, zonally decreasing at the tumor periphery [38].…”

“…Review of the literature confirms that the rate of cervical lymph node metastases is approximately 25 % and one-third of patients have developed local recurrence. Although classified as a low-grade malignancy, pulmonary metastases, widespread metastases, and diseaserelated mortality are uncommon but documented [36,37,39,[41][42][43][44]. Progression in histological grade (high-grade transformation), e.g.…”

Late Neck Metastasis of Clear Cell Salivary Carcinoma of the Soft Palate

“…The incidence of late recurrence may be higher than that reported in the literature, as many cases lack long-term follow-up data. 1 To detect a recurrence of salivary gland malignancy, FNAB alone may not be sufficient. A negative FNAB finding has been reported to carry a low predictive value, with more than half of the negative FNAB specimens at a tertiary care cancer center found to represent neoplasms on final histological assessment.…”