Hyalinizing clear cell carcinoma in the nasopharynx: A case report and literature review

Abstract

Rationale: Hyalinizing clear cell carcinoma (HCCC) arising from a minor salivary gland is a rare malignant neoplasm. Most HCCC has been reported in the palate and tongue base, and only rarely in the nasopharynx. Here, we report a rare case of nasopharyngeal HCCC. Patient concerns: A 44-year-old male who complained of otorrhea and aural fullness for 5 years was found to have a nasopharyngeal mass. Diagnoses: HCCC by fluorescence in situ hybridization analysis. Interventions: Surgical resection plus concurrent chemotherapy and radiation therapy were administered. Outcomes: The patient recovered well with symptoms improved at postoperative follow-up. Lessons: HCCC should be included in the differential diagnosis of nasopharyngeal mass. Overall, the prognosis of HCCC is positive after tumor resection and adequate management.