Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

Valachová, Katarína; Šoltés, Ladislav

doi:10.3390/ijms22137077

Cited by 44 publications

(36 citation statements)

References 172 publications

(216 reference statements)

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“…As is well known, one of the hallmarks of chronic wounds is the prolonged period of inflammation caused by the production of ROS and matrix-degrading enzymes (e.g., proteases and matrix metalloproteinases). Therefore, the most important mechanism of hyaluronic acid in tissue regeneration is its capability to function as a free radical scavenger in the process of tissue granulation formation [ 32 ]. Hinokitiol exerts a significant protective effect against epithelial surface inflammation by inhibiting the NF-κB pathway, which indicates that it could relieve inflammation [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Hinokitiol and Dicalcium Phosphate on the Osteoconduction and Antibacterial Activity of Gelatin-Hyaluronic Acid Crosslinked Hydrogel Membrane In Vitro

et al. 2021

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Many hydrogel-based crosslinking membranes have been designed and tailored to meet the needs of different applications. The aim of this research is to design a bifunctional hydrogel membrane with antibacterial and osteoconducting properties to guide different tissues. The membrane uses gelatin and hyaluronic acid as the main structure, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as the crosslinker, hinokitiol as the antibacterial agent, and dicalcium phosphate anhydrous (DCPA) micron particles for osteoconduction. Results show that the hydrogel membrane with added DCPA and impregnated hinokitiol has a fixation index higher than 88%. When only a small amount of DCPA is added, the tensile strength does not decrease significantly. The tensile strength decreases considerably when a large amount of modified DCPA is added. The stress–strain curve shows that the presence of a large amount of hinokitiol in hydrogel membranes results in considerably improved deformation and toughness properties. Each group impregnated with hinokitiol exhibits obvious antibacterial capabilities. Furthermore, the addition of DCPA and impregnation with hinokitiol does not exert cytotoxicity on cells in vitro, indicating that the designed amount of DCPA and hinokitiol in this study is appropriate. After a 14-day cell culture, the hydrogel membrane still maintains a good shape because the cells adhere and proliferate well, thus delaying degradation. In addition, the hydrogel containing a small amount of DCPA has the best cell mineralization effect. The developed hydrogel has a certain degree of flexibility, degradability, and bifunctionality and is superficial. It can be used in guided tissue regeneration in clinical surgery.

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Section: Discussionmentioning

confidence: 99%

Effects of Hinokitiol and Dicalcium Phosphate on the Osteoconduction and Antibacterial Activity of Gelatin-Hyaluronic Acid Crosslinked Hydrogel Membrane In Vitro

et al. 2021

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“…Meanwhile, the HA which supports ECM plays an important role in the interaction among cells. It also exhibits biodegradability by hepatic cells or hyaluronidase in plasma [104].…”

Section: Hamentioning

confidence: 99%

Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications

Lei

Feng

et al. 2022

Pharmaceutics

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The encapsulation of cells with various polyelectrolytes through layer-by-layer (LbL) has become a popular strategy in cellular function engineering. The technique sprang up in 1990s and obtained tremendous advances in multi-functionalized encapsulation of cells in recent years. This review comprehensively summarized the basis and applications in drug delivery by means of LbL cell encapsulation. To begin with, the concept and brief history of LbL and LbL cell encapsulation were introduced. Next, diverse types of materials, including naturally extracted and chemically synthesized, were exhibited, followed by a complicated basis of LbL assembly, such as interactions within multilayers, charge distribution, and films morphology. Furthermore, the review focused on the protective effects against adverse factors, and bioactive payloads incorporation could be realized via LbL cell encapsulation. Additionally, the payload delivery from cell encapsulation system could be adjusted by environment, redox, biological processes, and functional linkers to release payloads in controlled manners. In short, drug delivery via LbL cell encapsulation, which takes advantage of both cell grafts and drug activities, will be of great importance in basic research of cell science and biotherapy for various diseases.

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“…In fact, high levels of HYALs have been observed in various tumor types such as brain, bladder, and metastatic breast cancer [ 12 ]. There is no rigorous definition of high-MW and low-MW HA, but generally speaking, high-MW HA is responsible for the maintenance of the homeostatic condition, with anti-angiogenic, immunosuppressive, and anti-inflammatory properties; low-MW HA plays an opposite effect, having a key role in pathological conditions [ 13 ].…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…HA represents a key molecule in a variety of medical, pharmaceutical, nutritional, and cosmetic applications since it has many useful advantages, including biocompatibility, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity [ 31 ]. For many years, it has been used in the treatment of osteoarthritis, cosmetics, and in ophthalmology, but there has been a growing interest in HA’s application in other fields of medicine such as skin wound healing, tissue engineering, dentistry, and targeted drug delivery systems [ 13 ]. In recent years, HA has been studied as an anticancer delivering system, not only for drugs, but also for imaging agents, gene plasmids, and photosensitizers [ 16 ].…”

Section: Therapeutic Applications Of Ha In Cancermentioning

confidence: 99%

Hyaluronic Acid-Based Nanomaterials Applied to Cancer: Where Are We Now?

2022

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Cancer cells normally develop the ability to rewire or reprogram themselves to become resistant to treatments that were previously effective. Despite progress in understanding drug resistance, knowledge gaps remain regarding the underlying biological causes of drug resistance and the design of cancer treatments to overcome it. So, resistance acquisition remains a major problem in cancer treatment. Targeted therapeutics are considered the next generation of cancer therapy because they overcome many limitations of traditional treatments. Numerous tumor cells overexpress several receptors that have a high binding affinity for hyaluronic acid (HA), while they are poorly expressed in normal body cells. HA and its derivatives have the advantage of being biocompatible and biodegradable and may be conjugated with a variety of drugs and drug carriers for developing various formulations as anticancer therapies such as micelles, nanogels, and inorganic nanoparticles. Due to their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tissues, tumor-targeting nanomaterial-based drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer. In this review, we aim to provide an overview of some in vitro and in vivo studies related to the potential of HA as a ligand to develop targeted nanovehicles for future biomedical applications in cancer treatment.

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Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

Cited by 44 publications

References 172 publications

Effects of Hinokitiol and Dicalcium Phosphate on the Osteoconduction and Antibacterial Activity of Gelatin-Hyaluronic Acid Crosslinked Hydrogel Membrane In Vitro

Effects of Hinokitiol and Dicalcium Phosphate on the Osteoconduction and Antibacterial Activity of Gelatin-Hyaluronic Acid Crosslinked Hydrogel Membrane In Vitro

Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications

Hyaluronic Acid-Based Nanomaterials Applied to Cancer: Where Are We Now?

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