Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis

Chang, Chi Ching; Hsieh, Mao Chih; Liao, Say Tsung; Chen, Yi Hsuan; Cheng, Chao; Huang, Pai Tsang; Lin, Yung Feng; Chen, Chien Ho

doi:10.1016/j.carbpol.2012.06.071

Cited by 54 publications

(52 citation statements)

References 36 publications

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“…These data suggest that HA displays different biological roles depending on molecule weight. HA weight is critical for HA action [16,34,35,36]. This is keeping with the report that HMW-HA inhibits apoptosis while HA oligosaccharides induce apoptosis in tumor cell lines [37].…”

Section: Discussionsupporting

confidence: 68%

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

et al. 2013

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Hyaluronan (HA) and its receptor CD44 are expressed at the maternal-fetal interface, but its role in early pregnancy remains unclear. Here, we found that primary decidual stromal cells (DSCs) continuously secreted HA and expressed its receptor CD44. Pregnancy-associated hormones up-regulated HA synthetase (HAS) 2 transcription and HA release from DSCs. High molecular weight-HA (HMW-HA), but not medium molecular weight (MMW-HA) or low molecular weight (LMW-HA), promoted proliferation and inhibited apoptosis of DSCs in a CD44-dependent manner. The in-cell Western analysis revealed HMW-HA activated PI3K/AKT and mitogen-activated protein kinase (MAPK)/ERK1/2 signaling pathways time-dependently. Blocking these pathways by specific inhibitor LY294002 or U0126 abrogated HMW-HA-regulated DSc proliferation and apoptosis. Finally, we have found that HA content, HA molecular weight, HAS2 mRNA level, and CD44 expression were significantly decreased in DSCs from unexplained miscarriage compared with the normal pregnancy. Collectively, our results indicate that higher level and greater molecular mass of HA at maternal-fetal interface contributes to DSc growth and maintenance of DSCs in human early pregnancy.

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Section: Discussionsupporting

confidence: 68%

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

et al. 2013

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“…[30] IL-1β suppression results in downregulation of matrix metalloproteinases which also aids in anti-inflammatory effects of HA[31] and further suppression of pro-inflammatory mediators IL-8, IL-6, prostaglandin E2, and TNF-α provides anti-inflammatory effects of intra-articular HA treatment. [3233]…”

Section: Discussionmentioning

confidence: 99%

Efficacy of arthrocentesis versus arthrocentesis with sodium hyaluronic acid in temporomandibular joint osteoarthritis: A comparison

Gurung

Singh

Mohammad

et al. 2017

Natl J Maxillofac Surg

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Introduction:Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease characterized by deterioration of articular tissue with concomitant osseous changes in the condyle and/or articular eminence, joint positive for TMJ noise with jaw movement or function, crepitus detected on palpation on opening, closing, right/left lateral, or protrusive movement. Hyaluronic acid (HA) is a polysaccharide of the family of glycosaminoglycans. HA has been shown to improve and restore normal lubrication in joint, provide nutrition to the avascular articulating disc, and stabilize the joint.Materials and Methods:Twenty patients with OA of TMJ with age limit between 18 and 60 years of age were enrolled in this study. Patients were randomly divided into two groups, in which one group received arthrocentesis only, and another group received arthrocentesis plus intra-articular injection of sodium HA (0.5 ml) in superior joint space in a cycle of 5 weekly arthrocentesis (one per week). Patients were followed at regular interval of 1st day, 5th day, 7th day, 4 weeks, 6 weeks, and 12 weeks. Assessment of clinical outcome was done in terms of reduction in pain (visual analog scale score), maximum mouth opening (MMO) in millimeters, painful/pain-free lateral or protrusive jaw movement, and clicking/crepitus in joint.Results:Significant reduction in pain was observed in both the groups. MMO, lateral and protrusive movements improved significantly in both groups; however, arthrocentesis with sodium HA was superior to arthrocentesis alone.Conclusion:Combination of arthrocentesis with HA injection showed much better outcome than arthrocentesis alone.

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“…Various reports in the literature suggest different roles for HMW and LMW HA in processes such as inflammation and wound healing. For example, antiinflammatory effects have been suggested for HMW-HA based on its inhibition of leukocyte migration in the murine air pouch model [4], reduction in gene expression levels of cytokines and matrix metalloproteases in arthritis models [5,6], and reduced production of interleukins in a model of ultraviolet (UV) light-induced corneal damage [7]. In contrast, small oligosaccharides derived by in vitro digestion of HA using hyaluronidases have been reported to stimulate inflammation in cell culture [8], and it has been suggested that LMW HA fragments which accumulate at sites of tissue injury and repair may stimulate inflammatory gene expression in macrophages [9].…”

Section: Lettermentioning

confidence: 99%

The Activity of Hyaluronan and Hyaluronidase PH20 in Inflammation-A Role by Reagent Contaminants?

Huang¹

2015

J Clin Cell Immunol

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Hyaluronan regulates PPARγ and inflammatory responses in IL-1β-stimulated human chondrosarcoma cells, a model for osteoarthritis

Cited by 54 publications

References 36 publications

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

Efficacy of arthrocentesis versus arthrocentesis with sodium hyaluronic acid in temporomandibular joint osteoarthritis: A comparison

The Activity of Hyaluronan and Hyaluronidase PH20 in Inflammation-A Role by Reagent Contaminants?

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