Hyaluronan scaffolds: A balance between backbone functionalization and bioactivity

Eng, Doris Hom; Caplan, Michael R.; Preul, Mark C.; Panitch, Alyssa

doi:10.1016/j.actbio.2009.12.049

Cited by 63 publications

(60 citation statements)

References 35 publications

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“…HA is a ubiquitously distributed linear glycosaminoglycan composed of repeating disaccharides of (1-3) and (1-4)-linked ␤-d-glucuronic acids and N-acetyl ␤-d-glucosamine monomers [6,7]. HA is also a ligand for cluster determinant 44 (CD44), a cell-surface receptor found on most cell types, and upregulation of HA has been reported following tissue injury and cellular motility [8].…”

Section: Introductionmentioning

confidence: 99%

The effect of hyaluronan on the motility of skin dermal fibroblasts in nanofibrous scaffolds

Qian

Jiang

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

The effect of hyaluronan on the motility of skin dermal fibroblasts in nanofibrous scaffolds

Qian

Jiang

et al. 2015

International Journal of Biological Macromolecules

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“…In vivo, predicted degradation rates for HA-PEG hydrogels would be much slower, as physiological hyaluronidase levels are much lower than that used in this study. While degradation was only monitored with respect to cross-linker concentration, varying the HA weight percent would expand the degradation profile 77 .…”

Section: Degradation Assaymentioning

confidence: 99%

Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

2011

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Hyaluronic acid (HA) is a naturally occurring polymer that holds considerable promise for tissue engineering applications. Current cross-linking chemistries often require a coupling agent, catalyst, or photoinitiator, which may be cytotoxic, or involve a multistep synthesis of functionalized-HA, increasing the complexity of the system. With the goal of designing a simpler one-step , aqueous-based cross-linking system, we synthesized HA hydrogels via Diels-Alder "click" chemistry. Furan-modified HA derivates were synthesized and cross-linked via dimaleimide poly(ethylene glycol). By controlling the furan to maleimide molar ratio, both the mechanical and degradation properties of the resulting Diels-Alder cross-linked hydrogels can be tuned. Rheological and degradation studies demonstrate that the Diels-Alder click reaction is a suitable cross-linking method for HA. These HA cross-linked hydrogels were shown to be cytocompatible and may represent a promising material for soft tissue engineering.iii

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“…Since hyaluronan is native to the body, it is non-immunogenic. Thus, many investigators have successfully utilized hyaluronan for viscosupplementation [38,39], electrospinning [40], sponges [41], coatings [42], films [43], and scaffolds [44,45]. These properties make hyaluronan attractive for tissue engineering and drug delivery.…”

Section: Chemical Properties Of Hyaluronanmentioning

confidence: 97%

Hyaluronan drug delivery systems are promising for cancer therapy because of their selective attachment, enhanced uptake, and superior efficacy

et al. 2015

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The emergence of nanomedicine and nanotechnology has started to change the clinical approaches for the diagnosis and treatment of diseases. Innovations include drug targeting and enhanced efficacy. A drug carrier that has many desired properties for nanomedicine is hyaluronan. It has high affinity for water, does not induce an immunological response for high molecular weight hyaluronan, and possesses functional groups for drug conjugation. Furthermore, many carcinomas naturally overexpress hyaluronan receptors. Therefore, hyaluronan is an attractive biopolymer for formulating drug delivery devices and has been chemically modified to make liposomes, nanoparticles, and pendant-chain systems. Hyaluronan is even being developed as an excipient to enhance the effectiveness of drugs. These results merit the commercialization of hyaluronan-based nanotechnology.

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Hyaluronan scaffolds: A balance between backbone functionalization and bioactivity

Cited by 63 publications

References 35 publications

The effect of hyaluronan on the motility of skin dermal fibroblasts in nanofibrous scaffolds

The effect of hyaluronan on the motility of skin dermal fibroblasts in nanofibrous scaffolds

Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

Hyaluronan drug delivery systems are promising for cancer therapy because of their selective attachment, enhanced uptake, and superior efficacy

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