Hyaluronic acid-based agents do not affect anastomotic strength in the rat colon, in either the presence or absence of bacterial peritonitis

Reijnen, Michel M.P.J.; Man, Ben M. de; Hendriks, T.; Postma, V.A.; Meis, Jacques F.; Goor, Harry van

doi:10.1046/j.1365-2168.2000.01506.x

Cited by 26 publications

(16 citation statements)

References 25 publications

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“…Controversies exits whether to use commercial antiadhesive products available today clinically when there is need for an intestinal anastomos 13 . Icodextrin 4% as well as hyaluronic-acid-carboxymethylcellulose membrane has, however, in animal studies not been noted to have any adverse effect on the anastomos 14,15 .…”

Section: Discussionmentioning

confidence: 96%

Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat

Tingstedt

Nehéz

Axelsson

et al. 2005

Int J Colorectal Dis

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Methods: An ileocolic anastomosis was performed under both "clean" and "septic"conditions in the rat. The treatment group received intraperitoneal poly-L-lysine and poly-Lglutamate while controls received sodium chloride. Abdominal adhesions, anastomosis leakage and burst pressure were analyzed after 1, 3, 5 and 7 days in the "clean" anastomosis model and after 7 days in the "septic" model.Results: A significant decrease (p<0.01) in the amount of adhesions was seen in animals treated with polypeptides after 1, 3, and 5 days, while no difference was seen after 7 days.The anastomosis demonstrated a significantly higher burst pressure as evaluated day 1 and 3 (p<0.05 and p<0.01, respectively) in the polypeptide treated animals while no difference was seen between the groups at days 5 or 7.Conclusion: The use of differently charged polypeptides administered intraperitoneal after surgery resulted in a significant decrease in the extent of postoperative adhesions.Furthermore, an increase in intestinal anastomosis safety, based on improved burst pressure during the first 3 days, i.e. the critical period during the healing process, was noted. No adverse effects were seen in surgery during "septic" conditions.

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Section: Discussionmentioning

confidence: 96%

Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat

Tingstedt

Nehéz

Axelsson

et al. 2005

Int J Colorectal Dis

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“…Undesirable results can be achieved like anastomosis leakage. Many factors can be associated with this unwanted outcome 1,2 . On the presence of peritonitis, the integrity of anastomosis became so important.…”

Section: Introductionmentioning

confidence: 99%

Effect of ozone on colon anastomoses in rat peritonitis model

et al. 2016

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PURPOSE:To investigate the effects of medical ozone theraphy on the colon anastomosis of peritonitis model in rats. METHODS:Eighteen rats were randomly assigned into three equal groups; control, cecal punctuation and colon anastomosis and ozone theraphy. Sepsis was performed with a cecal punctuation in groups 2 and 3. The medical ozone theraphy was administered intraperitonealy for three weeks in group 3 while the other rats received saline injection. At the twenty second day serum were obtained for TNF-α and IL-1β, the colonic burst pressures were measured and colonic tissue samples were obtained for MDA and MPO levels.Histolopatological examination was evaluated with H&E stain, and Ki-67, IL-1β and the VEGF immunostaining densities were also compared. RESULTS:Intraperitoneal ozone administration reversed TNF-α, IL-1β, MDA and MPO levels and the colonic burst pressures. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSION:Medical ozone therapy may contribute to tissue healing by affecting the proliferation and the vascularization thus has benefits on colonic anastomosis at peritonitis in rats.

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“…Entretanto, não é método isento de críticas, pois não diferencia o colágeno do ponto de vista qualitativo e sim quantitativo. E, na literatura, mesmos avaliações como a dosagem tecidual de hidroxiprolina sofre críticas, pois não diferencia se a proteína encontrada advém da área da anastomose ou não 16 . Desta forma, somando-se os métodos pôde-se comprovar histologicamente que os animais tratados com Aroeira (mesmo em dose única após a operação) apresentavam fase de cicatrização na anastomose mais adiantada quando comparada com o GC.…”

Section: Colagenização (Figura 3)unclassified

Efeito do extrato hidroalcoólico de Aroeira (Schinus terebinthifolius Raddi) na cicatrização de anastomoses colônicas: estudo experimental em ratos

Coutinho

Torres

Matias³

et al. 2006

Acta Cir. Bras.

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RESUMO Introdução:A cicatrização é evento biológico complexo envolvendo inflamação, quimiotaxia, proliferação celular, diferenciação e remodelação. Na medicina popular brasileira, utiliza-se a Aroeira para tratar as mais diversas situações patológicas No Estado do Maranhão -Brasil, a Aroeira é extensivamente utilizada no tratamento de afecções do aparelho respiratório, digestivo e ginecológico. As anastomoses intestinais sempre foram motivo de preocupação para cirurgiões e constituem, até hoje assunto polêmico e repleto de controvérsias. Entre as causas de insucesso da anastomose intestinal destacam-se as fístulas e deiscências. Objetivo: Avaliar o efeito do extrato hidroalcoólico de Aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de anastomoses colônicas em ratos. Métodos: Foram utilizados 40 ratos da linhagem Wistar divididos em dois grupos (grupo Aroeira e grupo controle), aleatoriamente, composto de 20 animais cada, de acordo com o tratamento recebido (extrato da Aroeira ou solução salina a 0,9%) após a anastomose, e subdividiu-se cada grupo em dois subgrupos (C3 e C7 e A3 e A7,) de acordo com o dia de eutanásia (ao 3º e 7º dias). As variáveis utilizadas para mensuração foram: análise macroscópica, microscópica e tensiométrica. As interações entre os grupos foram analisadas pelo teste não-paramétrico de Mann-Whitney. Resultados: Quanto ao grau de adesão, não foi observado diferença significativa entre os grupos Aroeira e controle tanto no 3º quanto no 7º dia. Quando se comparam os subgrupos do ponto de vista microscópico no 3º dia, a diferença entre o grupo que recebeu o extrato da Aroeira e o grupo controle foi significativa nas variáveis congestão (p = 0,005), polimorfonucleares (p = 0,034), mononucleares (p = 0,023), proliferação fibroblástica (p = 0,023) e na fase de cicatrização (p = 0,001). Na análise do 7º dia, todas as variáveis da análise microscópica foram significativas o que levou a 100% dos ratos do grupo Aroeira apresentarem inflamação crônica contra 20% do grupo controle. Em relação ao teste de pressão de ruptura, não houve diferença estatisticamente significante entre os grupos controle e Aroeira. Conclusão: Observou-se efeito favorável da Aroeira, a nível microscópico, no processo de cicatrização de anastomoses de cólon. Descritores: Cicatrização de Feridas. Anacardiaceae. Anastomose Cirurgica. Colo. ABSTRACT Introduction:The healing is a complex biological event that involves inflammation, chemotaxis, cells proliferation, differentiation and remodelation. In Brazilian popular medicine, the "Aroeira" is used to treat different situations The anastomotic healing is always a preoccupation among surgeons. The fail in intestinal anastomosis leads to fistulas and dehiscences. Purpose: To evaluate the effect of the hidroalcoholic extract of Schinus terebinthifolius Raddi (brazilian peppertree) in the healing of colonic anastomosis. Methods: Forty Wistar rats were randomly divided in two groups (Aroeira and control), each one with 20 animals, according to the treatment received...

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Hyaluronic acid-based agents do not affect anastomotic strength in the rat colon, in either the presence or absence of bacterial peritonitis

Abstract: Neither HA-CMC bioresorbable membrane nor 0.4 per cent HA solution interferes with the development of early anastomotic strength in the colon, and can therefore be safely used to prevent intra-abdominal adhesion formation after performing bowel anastomosis.

Cited by 26 publications

References 25 publications

Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat

Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat

Effect of ozone on colon anastomoses in rat peritonitis model

Efeito do extrato hidroalcoólico de Aroeira (Schinus terebinthifolius Raddi) na cicatrização de anastomoses colônicas: estudo experimental em ratos

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