2022
DOI: 10.3390/pharmaceutics14020466
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Hyaluronic Acid Nanoparticles for Immunogenic Chemotherapy of Leukemia and T-Cell Lymphoma

Abstract: Ratiometric delivery of combination chemotherapy can achieve therapeutic efficacy based on synergistic interactions between drugs. It is critical to design such combinations with drugs that complement each other and reduce cancer growth through multiple mechanisms. Using hyaluronic acid (HA) as a carrier, two chemotherapeutic agents—doxorubicin (DOX) and camptothecin (CPT)—were incorporated and tested for their synergistic potency against a broad panel of blood-cancer cell lines. The pair also demonstrated the… Show more

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Cited by 7 publications
(1 citation statement)
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“…The CD47 agonist peptide PKHB1, hyaluronic acid nanoparticles, Withania somnifera, and photodynamic therapy can all be used to induce ICD in lymphocytic leukemia cells. [154][155][156][157] But, more efficient ICD inducers need to be explored.…”
Section: Lymphocytic Leukemiamentioning
confidence: 99%
“…The CD47 agonist peptide PKHB1, hyaluronic acid nanoparticles, Withania somnifera, and photodynamic therapy can all be used to induce ICD in lymphocytic leukemia cells. [154][155][156][157] But, more efficient ICD inducers need to be explored.…”
Section: Lymphocytic Leukemiamentioning
confidence: 99%