Hybrid and Model‐Based Iterative Reconstruction Influences the Volumetry of Visceral and Subcutaneous Adipose Tissue on Ultra‐Low‐Dose CT

Lambert, Lukáš; Novak, Matej; Šiklová, Michaela; Krauzová, Eva; Štich, Vladimír; Burgetová, Andrea

doi:10.1002/oby.22945

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…In the treatment of bladder cancer, it is necessary to frequently check the blood routine and biochemical indicators of the patient [19]. Ceramide can induce cell apoptosis, and its synthetase can generate glucosylceramide by catalyzing sugar groups and combining with ceramide [20][21][22], while glucosylceramide can promote cell proliferation and reduce the therapeutic effect of anticancer drugs [23]. In this study, the immunohistochemistry was adopted to detect the expression of GCS in the bladder tissues of the patients in two groups.…”

Section: Discussionmentioning

confidence: 99%

Multislice Spiral Computed Tomography under Hybrid Iterative Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer and Ceramide Glycosylation

Liu

Jiang

2021

Scientific Programming

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This study was to discuss the application of multislice spiral computed tomography (CT) in the staging diagnosis of bladder cancer and the effect of ceramide glycosylation. The hybrid iterative reconstruction algorithm was applied. Immunohistochemistry and western blot were used to detect the normal bladder tissues (30 cases) of GCS in group 1 (100 cases) and group 2. The scanned images of all the research objects were obtained, the images with the iterative reconstruction algorithm were reconstructed, and statistical analysis on the CT value under the algorithm was conducted. The results showed that the image quality, blood vessel sharpness, average image score, signal-to-noise ratio, and radiation dose after the spiral CT and iterative reconstruction algorithm all increased, while the noise value decreased. The optical density value of glucosylceramide synthase in group 2 patients increased by 71%, and the optical density value of group 1 increased by 29%. The optical density expression of glucosylceramide synthase in group 1 patients was significantly higher than that in the control group, and there was a statistical difference between the two ( P < 0.05 ). Among the results of multislice spiral CT for tumor staging, the lesions larger than 5 cm and in the range of 1.1–2 cm in diameter were more sensitive. In 41 patients, there were multiple lesions. A total of 142 cancer lesions were found. The diameter of the tissue ranged from 0.5 to 6.8 cm, with an average diameter of 2.03 ± 0.35 cm. The optical density of glucosylceramide synthase in the group 1 was 5526, and the optical density in group 2 was 2576. The OD expression of GCS in group 1 was greatly higher in contrast to that in group 2, and there was a statistical difference between the two groups ( P < 0.05 ). The multislice spiral CT examination under this algorithm found that the diagnosis and staging accuracy of lesions with a diameter greater than 5 cm and tumor diameters in the range of 1.1 to 2 cm was higher. The image processed by the hybrid iterative reconstruction algorithm had good effect, high definition, and accuracy.

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Section: Discussionmentioning

confidence: 99%

Multislice Spiral Computed Tomography under Hybrid Iterative Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer and Ceramide Glycosylation

Liu

Jiang

2021

Scientific Programming

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“…Glucose disposal was calculated from the last 30‐min steady‐state glucose infusion rate (glucose disposal, corrected for body fat‐free mass [FFM] = milligrams of infused glucose per kilograms of FFM per minute; metabolic clearance = M‐value per mean glucose in steady state × [100/18] [milliliters per kilograms per minute]). In the majority of participants (CON [ n = 18]; FDR [ n = 16]), computed tomography scanning for the evaluation of visceral AT (VAT) and SAT volume was performed as described previously [20].…”

Section: Methodsmentioning

confidence: 99%

The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross‐sectional study

Šiklová,

Šrámková,

Koc

et al. 2024

Obesity

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ObjectiveThis study tested the hypothesis that limited subcutaneous adipose tissue (SAT) expansion represents a primary predisposition to the development of type 2 diabetes mellitus (T2DM), independent of obesity, and identified novel markers of SAT dysfunction in the inheritance of T2DM.MethodsFirst‐degree relatives (FDR) of T2DM patients (n = 19) and control individuals (n = 19) without obesity (fat mass < 25%) were cross‐sectionally compared. Body composition (bioimpedance, computed tomography) and insulin sensitivity (IS; oral glucose tolerance test, clamp) were measured. SAT obtained by needle biopsy was used to analyze adipocyte size, lipidome, mRNA expression, and inflammatory markers. Primary cultures of adipose precursors were analyzed for adipogenic capacity and metabolism.ResultsCompared with control individuals, FDR individuals had lower IS and a higher amount of visceral fat. However, SAT‐derived adipose precursors did not differ in their ability to proliferate and differentiate or in metabolic parameters (lipolysis, mitochondrial oxidation). In SAT of FDR individuals, lipidomic and mRNA expression analysis revealed accumulation of triglycerides containing polyunsaturated fatty acids and increased mRNA expression of lysyl oxidase (LOX). These parameters correlated with IS, visceral fat accumulation, and mRNA expression of inflammatory and cellular stress genes.ConclusionsThe intrinsic adipogenic potential of SAT is not affected by a family history of T2DM. However, alterations in LOX mRNA and polyunsaturated fatty acids in triacylglycerols are likely related to the risk of developing T2DM independent of obesity.image

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“…Some scholars reconstructed multiorientation simultaneous computation of back-projection (MSBP) between image pixels and projection rays in different projection directions [11]. In the processing of CT images, MSBP algorithm can be used for rapid calculation in the space domain of direct back-projection, further reducing the amount of calculation in pixel positioning operation [12][13][14]. At present, there are very few data to apply HIR algorithm to CT scan images of bladder cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Multiorientation Simultaneous Computation of Back-Projection CT Image Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer

Zhu

et al. 2022

Computational and Mathematical Methods in Medicine

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The objective of this research was to investigate the multidirectional synchronous calculation of the back-projection computed tomography (CT) image reconstruction algorithm (MSBP) in the staging diagnosis of bladder cancer. Sixty patients with bladder cancer admitted to the hospital were selected for enhanced CT scanning, all of which were randomly divided into control group ( n = 30 ) and study group ( n = 30 ). The filtered back-projection (FBP) algorithm was employed to reconstruct the scanned image, and the MSBP was additionally applied to the images of the study group. Fringe artifact (SA), overall mass (OQ), effective radiation dose (ED), CT dose-exponential volume (CTDI), and dose-length product (DLP) of the two groups of images were compared and analyzed. The results showed that the total time of the traditional algorithm was 5.473 s, and the total time of MSBP combined with FBP algorithm was 2.832 s, which was significantly higher than that of the traditional algorithm ( P < 0.05 ). CT scan bladder cancer staging results of all patients were compared with surgical pathological staging results, and the results were evaluated according to the coincidence rate. SA in the study group was lower than that in the control group ( P < 0.05 ), and OQ was not statistically significant. The ED of the study group was significantly lower than that of the control group by 33%. The coincidence rate of postoperative pathological staging results and CT staging results was 96%, and T1, T2a, and T4 coincidence rate was 100%, The coincidence rates of T2b, T3a, and T3b were 90%, 83.3%, and 66.67%, respectively. In summary, using MSBP method combined with FBP algorithm can improve OQ while reducing ED of patients. The introduction of MSBP into CT reconstruction image simplified the pixel location operation of projection calculation, showing an important application value in preoperative staging diagnosis of bladder cancer.

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Hybrid and Model‐Based Iterative Reconstruction Influences the Volumetry of Visceral and Subcutaneous Adipose Tissue on Ultra‐Low‐Dose CT

Cited by 4 publications

References 27 publications

Multislice Spiral Computed Tomography under Hybrid Iterative Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer and Ceramide Glycosylation

Multislice Spiral Computed Tomography under Hybrid Iterative Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer and Ceramide Glycosylation

The role of adipogenic capacity and dysfunctional subcutaneous adipose tissue in the inheritance of type 2 diabetes mellitus: cross‐sectional study

Multiorientation Simultaneous Computation of Back-Projection CT Image Reconstruction Algorithm in Staging Diagnosis of Bladder Cancer

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