Hybrid compounds for improving drugs solubility: Synthesis, physico-chemical and pharmaceutical characterization of Nimesulide-LDH

Bini, Marcella; Monteforte, Francesco; Quinzeni, Irene; Friuli, Valeria; Maggi, Lauretta; Bruni, Giovanna

doi:10.1016/j.jssc.2019.02.001

Cited by 21 publications

(14 citation statements)

References 23 publications

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“…In some cases, the basal spacing between the layers can vary widely depending on the size of the guest 7 which allows a variety of species, such as drugs, to be intercalated. Intercalation of drugs into a layered material can be achieved by several routesmost commonly by ion exchange (diffusion of drug ions from solution into the interlayer space) [8][9][10][11] and co-precipitation (synthesis in the presence of neutral or ionic drug species), [12][13][14][15] but also reconstruction (calcination and reaction with drug solution), 16,17 and exfoliationreassembly (separation of layered material into sheets, and reassembly in drug solution). 18,19 There exist many layered systems which are comprised of negatively charged layers and are therefore cation-exchangeable, for example metal oxides, 20 metal phosphates, 21 and aluminophosphates.…”

Section: Introductionmentioning

confidence: 99%

Layered terbium hydroxides for simultaneous drug delivery and imaging

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Layered terbium hydroxides for simultaneous drug delivery and imaging

et al. 2021

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“…These materials, with anions compensating for the lamellae, can be used as adsorbents for anionic compounds, including both inorganic [ 5 , 6 , 7 , 8 , 9 ] and organic [ 10 , 11 , 12 , 13 ] compounds, and applied to several fields, such as drug delivery [ 14 , 15 , 16 , 17 , 18 ] and effluent and water treatments [ 19 , 20 , 21 ]. However, they are not efficient for the adsorption of cations.…”

Section: Introductionmentioning

confidence: 99%

Memory Effect on a LDH/zeolite A Composite: An XRD In Situ Study

et al. 2021

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In this memory effect study, hydrotalcite-type compounds in the lamellar double hydroxide-like (LDH)/zeolite A composite material were analyzed using X-Ray Diffration XRD) in situ experiments. Three samples were analyzed: Al,Mg-LDH, Al,Mg-LDH/ZA composite, and a physical mixture (50/50 wt%) of zeolite A and Al,Mg-LDH. The Al,Mg-LDH sample was treated at 500 °C in an O2 atmosphere and subsequently rehydrated. The Al,Mg-LDH/ZA composites had three treatments: one was performed at 300 °C in a He atmosphere, and two treatments were performed with an O2 atmosphere at 300 and 500 °C. In the physical mixture, two treatments were carried out under O2 flow at 500 °C and under He flow at 300 °C. Both went through the rehydration process. All samples were also analyzed by energy dispersive spectroscopy (EDS) and scanning electron microscopy (SEM). The results show that the LDH phase in the Al,Mg-LDH/ZA compounds has memory effects, and thus, the compound can be calcined and rehydrated. For the LDH in the composite, the best heat treatment system is a temperature of 300 °C in an inert atmosphere.

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“…[11][12] Through the incorporation of guest species, such as polymers into a layered host, novel nanocomposites can be engineered with desirable physical and chemical properties. [13][14][15] In the present article, we have designed conducting polymer intercalated LDH nanocomposites. The synthesized nanocomposites were analyzed by fourier transform infrared spectroscopy (FTIR), ultraviolet visible spectroscopy (UV), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission microscopy (TEM) and thermogravimetric analysis (TGA) studies.…”

Section: Introductionmentioning

confidence: 99%

“…[ 11‐12 ] Through the incorporation of guest species, such as polymers into a layered host, novel nanocomposites can be engineered with desirable physical and chemical properties. [ 13‐15 ]…”

Section: Introductionmentioning

confidence: 99%

Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents

Riaz

Singh

Verma

et al. 2020

Polymer Engineering & Sci

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The synthesis of layered double hydroxide (LDH) was carried out using different ratios of Mg:Al. The intercalation of polypyrrole (Ppy) within interlayer space of LDH was carried out via ultrasonication using different loadings of the conducting polymer. Fourier transform infrared (FTIR) spectra and XRD analysis showed successful intercalation of Ppy in LDH while UV-visible spectra confirmed polaronic state of the conducting polymer within the LDH. Scanning electron microscopy and transmission electron microscopy studies showed successful incorporation of Ppy and loading of the drug was also established. The concentration of Rifampicin, an antituberculosis drug in LDH/Ppy, was confirmed by Langmuir adsorption isotherm. The in vitro release characteristics showed sustained release behaviour at pH 7.4 for a period of 180 hours. The nanocomposites exhibited immense potential for their application as Rifampicin drug carriers.

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Hybrid compounds for improving drugs solubility: Synthesis, physico-chemical and pharmaceutical characterization of Nimesulide-LDH

Cited by 21 publications

References 23 publications

Layered terbium hydroxides for simultaneous drug delivery and imaging

Layered terbium hydroxides for simultaneous drug delivery and imaging

Memory Effect on a LDH/zeolite A Composite: An XRD In Situ Study

Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents

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