Hybrid functionalized coatings on Metallic Biomaterials for Tissue Engineering

Santos-Coquillat, Ana; Martínez-Campos, Enrique; Sánchez, H.; Moreno, Lara; Arrabal, R.; Mohedano, M.; Gallardo, Alberto; Rodríguez‐Hernández, Juan; Matykina, E.

doi:10.1016/j.surfcoat.2021.127508

Cited by 37 publications

(17 citation statements)

References 525 publications

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“…Main characteristics of PEO process is the possibility to proper functionalize the coatings thank to the addition of particles into the electrolyte [25] or thank to interactions between the electrolyte and the substrate [26]. In this way the coating resulted composed not only by the oxide of the substrate but also by other compounds, that can confer to the coating proper characteristics, for example cytocompatibility [27] or bactericidal effect [28,29]. The electrolyte employed in the formation of PEO coatings on Ti alloys are usually basic aqueous electrolytes but also other innovative solutions, such as molten salts electrolytes [30,31], have been recently studied in order to further functionalize the obtained coatings.…”

Section: Introductionmentioning

confidence: 99%

Investigation of hydroxyapatite (HAP) containing coating on grade 2 titanium alloy prepared by plasma electrolytic oxidation (PEO) at low voltage

Kostelac

Pezzato

Settimi

et al. 2022

Surfaces and Interfaces

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Section: Introductionmentioning

confidence: 99%

Investigation of hydroxyapatite (HAP) containing coating on grade 2 titanium alloy prepared by plasma electrolytic oxidation (PEO) at low voltage

Kostelac

Pezzato

Settimi

et al. 2022

Surfaces and Interfaces

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“…37,38 Cypher and Taxus (Boston Scientific) use a mixture of poly(ethylene-co-vinyl acetate), poly(n-butyl methacrylate), and poly(styrene-β-isobutylene-β-styrene). 6,39 A detailed description is presented in the next section.…”

Section: Drugs For the Treatment Of Restenotic And Thrombotic Conditionsmentioning

confidence: 99%

“…Great importance lies in the ability to generate stent coatings that allow drug delivery directly into the artery . To accomplish this challenge, DESs are typically coated with a polymer functionalized with an antiproliferative drug. , Cypher and Taxus (Boston Scientific) use a mixture of poly(ethylene- co -vinyl acetate), poly( n -butyl methacrylate), and poly(styrene-β-isobutylene-β-styrene). , A detailed description is presented in the next section.…”

Section: Drugs For the Treatment Of Restenotic And Thrombotic Conditionsmentioning

confidence: 99%

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

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Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.

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“…Ocorreu o aumento na busca por implantes ósseos nas últimas décadas devido ao desenvolvimento tecnológico ocorrido na área da medicina regenerativa e pesquisa por novos materiais (Parent et al, 2016;Santos-Coquillat et al, 2021). No campo do desenvolvimento de implantes e/ou preenchimentos ósseos, os fosfatos de cálcio (CaPs) se destacam por possuírem um perfil biológico altamente atrativo, pois apresentam composição química muito semelhante à fase mineral dos ossos e dentes (íons fosfato e cálcio).…”

Section: Introductionunclassified

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

2022

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da UFCG. Atua no desenvolvimento de novos materiais via síntese química, atividades relacionadas à nanotecnologia e desenvolvimento de materiais para aplicação em eletro-eletrônica, catálise, materiais magnéticos, ópticos, nanocompósitos, biomateriais, membranas cerâmicas e marcadores biológicos. Possui experiência em síntese e caracterização de materiais, desenvolvimento de materiais magnéticos para aplicações em catálise, absorvedores de radiação eletromagnética, marcadores biológicos e dispositivos magnéticos moles. Participa como membro permanente do Programa de Pós-Graduação em Ciências e Engenharia de Materiais (conceito CAPES 5). Também atua na formação de recursos humanos participando ativamente dos programas de

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Hybrid functionalized coatings on Metallic Biomaterials for Tissue Engineering

Cited by 37 publications

References 525 publications

Investigation of hydroxyapatite (HAP) containing coating on grade 2 titanium alloy prepared by plasma electrolytic oxidation (PEO) at low voltage

Investigation of hydroxyapatite (HAP) containing coating on grade 2 titanium alloy prepared by plasma electrolytic oxidation (PEO) at low voltage

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

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