In this paper, the features of electrical power steering (EPS) and semi-active suspension (SAS) systems have been carefully researched, and an integrated control strategy based on neural network theory was proposed to achieve the integrated control of EPS and SAS systems. In order to achieve the simulation of the integrated control strategy, a neural network controller of EPS and SAS systems was designed under MATLAB environment, and a passenger car virtual prototyping model including the EPS and SAS systems was established in vehicle dynamics simulation software SIMPACK. By ride comfort and handing stability simulation, the integrated control strategy was proved to be effective. The primary goal of this paper is to propose an effective and reliable integrated control strategy of EPS and SAS systems, and improve the ride comfort as well as handing stability of automobile.