Hybrid gelatin-based porous materials with a tunable multiscale morphology for tissue engineering and drug delivery

Salerno, Aurelio; Verdolotti, Letizia; Raucci, Maria Grazia; Saurina, Javier; Domingo, Concepción; Lamanna, Raffaele; Iozzino, Valentina; Lavorgna, Marino

doi:10.1016/j.eurpolymj.2017.12.024

Cited by 37 publications

(15 citation statements)

References 25 publications

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“… Chloroquine Chloroquine has in vitro activity against SARS-CoV-2 and has immunomodulating properties [15] , [70] , [77] . Hydroxychloroquine Hydroxychloroquine has in vitro activity against SARS-CoV-2 and may have immunomodulating properties [2] , [7] , [15] , [22] , [23] , [60] , [70] . Lopinavir In vitro and animal model studies show potential activity for other coronaviruses (SARS-CoV and MERS-CoV) [13] , [14] , [76] .…”

Section: Treatment Methodology Of Covid-19mentioning

confidence: 99%

“…Mechanisms involved inhibition of viral several enzymes or systems such as viral DNA and RNA polymerase, glycosylation of viral protein, virus assembly, new virus particle transport, and virus discharge. Other mechanisms may also involve ACE2 cellular receptor inhibition, acidification at the surface of the cell membrane repressing fusion of the virus, and immunomodulation of cytokine release [2] , [7] , [16] , [22] , [23] , [60] , [70] .…”

Section: Treatment Methodology Of Covid-19mentioning

confidence: 99%

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Nanoparticles as an effective drug delivery system in COVID-19

Chowdhury¹,

Deepika²,

Choudhury³

et al. 2021

Biomedicine & Pharmacotherapy

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Background The global healthcare sector has been dealing with a situation known as a novel severe acute respiratory syndrome (SARS-CoV-2) since the end of 2019. Covid-19 is an acronym for Covid-19 (Coronavirus Disease- 2019). It causes a respiratory infection that includes cold, sneezing and coughing, and pneumonia. In the case of an animal, it causes diarrhea and upper respiratory diseases. Covid-19 transmitted human to human via airborne droplets. First Covid-19 emerged in Wuhan market China and it spread rapidly throughout the World. As we know nanoparticles are a novel drug delivery system. They have various advantageous effects like increasing the efficacy of the drug, safety, etc. In this review, we study about the nanoparticles and summarize how it is effective during drug delivery system in Covid-19. Chitosan is a much focused biopolymeric nanoparticle. It delivers drugs to the specific target site. In a recent health crisis, chitosan nanoparticles are one of the ways to release drugs of Covid-19, and specifically in the lungs of the affected patients. We studied and extracted our data from various research papers, review papers, and some other articles. Objective The main goal is to study the nanoparticles and their future aspects which is an effective drug delivery system in Covid-19. Methods The bibliographic search was done through a systematic search. The terms “Nanoparticles”, “Covid-19 ”, “Drug delivery” etc. were used to search the databases/search engines like “Google Scholar”, “NCBI”, “PubMed”, “Science Direct” etc. These databases and search engines used here perform the limited criteria of search to conduct a systematic literature survey for the study and report writing. All the text from the articles and research papers were studied and analyzed. The various articles and research papers were used in writing this report and all of which are mentioned in the reference section of this report. Conclusion Our current studies reveal that nanoparticles may prove very helpful in the delivery of drugs for Covid-19 treatment. Many cases showed that patients, where drugs are delivered with the help of nanoparticles, produced very few side effects.

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Section: Treatment Methodology Of Covid-19mentioning

confidence: 99%

Section: Treatment Methodology Of Covid-19mentioning

confidence: 99%

Nanoparticles as an effective drug delivery system in COVID-19

Chowdhury¹,

Deepika²,

Choudhury³

et al. 2021

Biomedicine & Pharmacotherapy

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“…The most currently used bio-safe technology for the production of drug-loaded devices is supercritical CO 2 (scCO 2 ) technology as it allows for upscaling drug deactivation problems related to the use of organic solvents and/or high temperatures ( Salerno et al, 2015 ). Indeed, CO 2 is ecofriendly and non-flammable, whereas scCO 2 is achievable at a rather low critical temperature (Tc = 31.1°C) and moderate critical pressure (Pc = 7.4 MPa) ( Salerno et al, 2017 , 2018 ). Several works reported the use of scCO 2 as a blowing agent for thermoplastic biocompatible polymer foaming and porous scaffold manufacturing ( Champeau et al, 2015 ; Salerno and Domingo, 2015 ).…”

Section: Strategies For Porous Scaffold Bioactivation By Drug Entrapment and Deliverymentioning

confidence: 99%

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Salerno¹,

Netti

2021

Front. Bioeng. Biotechnol.

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In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.

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“…However, the unmodified GE adhesives have poor water resistance and low mechanical properties during the bonding process because of the largely exited hydrophilic groups on GE chains . According to previous studies, the defects of GE adhesives can be made up for by adding surfactants , and modifying agents. , Among them, epoxy compounds are the most commonly used modifying agents. , The ring-opening reaction occurred between the epoxy group and some active groups in GE such as amino groups and carboxyl groups under mild conditions, which was owing to the charge polarization and ring tension of epoxy groups . This way, we can form a three-dimensional network structure for improving the mechanical properties of products …”

Section: Introductionmentioning

confidence: 99%

Novel Gelatin-based Eco-friendly Adhesive with a Hyperbranched Cross-linked Structure

Wang

Zhu

Liu

et al. 2020

Ind. Eng. Chem. Res.

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Gelatin (GE), a nontoxic and degradable biomass resource, is a multistage hydrolysate of collagen. However, its application in adhesives was always limited by its brittleness and poor water resistance. In order to overcome this shortcoming, herein, epoxy-terminated hyperbranched polymers (EHPAEs) were first selected as a cross-linking agent to modify the GE extracted from leather solid wastes to prepare a series of novel GE-based environmentally friendly adhesives. First, EHPAE was synthesized and the structure of the hyperbranched polymer was measured by Fourier-transform infrared and 1H NMR spectroscopy. Then, the adhesives were obtained using the EHPAE to modify GE. The adhesion effect of the prepared adhesives was evaluated by tensile and T-peel tests on the surface of leather, in order to determine whether this adhesive achieved the quality requirements for footwear and bags. The result indicated that EHPAE-modified GE-based adhesives had higher solid content, superior adhesion ability, and water resistance. Moreover, the bonding layer of this adhesive was tough and ductile, while the bonding layers of the recently reported GE-based adhesives were brittle. This adhesive also surpassed the recently reported GE-based adhesives in terms of water resistance and adhesion performance.

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Hybrid gelatin-based porous materials with a tunable multiscale morphology for tissue engineering and drug delivery

Cited by 37 publications

References 25 publications

Nanoparticles as an effective drug delivery system in COVID-19

Nanoparticles as an effective drug delivery system in COVID-19

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Novel Gelatin-based Eco-friendly Adhesive with a Hyperbranched Cross-linked Structure

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