In this paper, an inkjet printed slotted disc monopole antenna is designed, printed, and analyzed at 2.45 GHz ISM band on a polyethylene terephthalate (PET) substrate for early detection of brain stroke. PET is used as a substrate due to its low loss tangent, flexible, and moistureresistant properties. By the implementation of slotting method, the size of this antenna is reduced to 40 × 38 mm 2 . The printed antenna exhibits 480 MHz (19.55%) bandwidth ranging from 2.25 GHz to 2.73 GHz frequency. It shows a radiation efficiency of 99% with a realized gain of 2.78 dB at 2.45 GHz frequency. The Monostatic Radar (MR) approach is considered to detect brain stroke by analyzing the variations in received signals from the head model with and without stroke. The maximum specific absorption rate (SAR) distribution at 2.45 GHz frequency is calculated. The compact size and flexible properties make this monopole antenna suitable for early detection of brain stroke.