Hybrid Hydrogels Based on Methacrylate-Functionalized Gelatin (GelMA) and Synthetic Polymers

Jia, Liang; Dijkstra, P.J.; Poot, Andreas A.; Grijpma, Dirk W.

doi:10.1007/s44174-022-00023-2

Cited by 13 publications

(7 citation statements)

References 92 publications

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“…In general, pHEMA/GelMA-based hydrogels reached their swelling equilibrium state in about 6 h, while pHEMA/gelatin-based hydrogels needed a longer time to reach equilibrium (∼20 h). Also, pHEMA/gelatin-based hydrogels have a higher swelling ratio than that of pHEMA/GelMA-based hydrogels due to their loose network. , The thermally cured hydrogel has a slightly higher swelling capacity as compared to the same type of hydrogel cured with NIR light (1.13–1.28 times) (Figure b). The slightly larger swelling capacity of the thermally cured hydrogels could be mainly due to their larger sizes as discussed above. , Additionally, both the thermally cured and NIR light-cured hydrogels showed similar water contents ranging from 33.6 to 35.6% (Table S1), indicating that faster polymerization does not result in significant water loss during hydrogel curing.…”

Section: Resultsmentioning

confidence: 97%

“…Also, pHEMA/gelatin-based hydrogels have a higher swelling ratio than that of pHEMA/GelMA-based hydrogels due to their loose network. 38,39 The thermally cured hydrogel has a slightly higher swelling capacity as compared to the same type of hydrogel cured with NIR light (1.13−1.28 times) (Figure 6b). The slightly larger swelling capacity of the thermally cured hydrogels could be mainly due to their larger sizes as discussed above.…”

Section: Morphology Of Nir Led Light-cured Hydrogelsmentioning

confidence: 96%

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Gold Nanorods Function as Near-Infrared Light-Activated Microheaters for In Situ Curing of Injectable Hydrogel Therapies

Pruksawan

Chee

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Injectable hydrogels have gained popularity as an attractive solution for wound dressing therapies due to their ability to conform to irregular wound sites and in situ polymerization. However, the harmful effects of ultraviolet (UV) exposure limit the applicability of photocuring methods, while thermal curing is limited by its high-temperature requirement and nonselective curing. To address these limitations, we present a method of curing hydrogels in situ by incorporating gold nanorods (AuNRs) as microheaters to initiate and regulate local thermal polymerization of the hydrogel upon exposure to near-infrared (NIR) light. In the present method, the well-dispersed AuNRs in the hydrogel presolution enable millions of microheaters to heat up the solution, resulting in a faster kinetic rate and higher polymerization conversion compared to the traditional thermal curing method. Moreover, the NIR light-initiated curing process leads to a more uniform microstructure and improved mechanical performance of hydrogels. This in situ, fast, and selective curing method presents a superior alternative to traditional curing methods and is an ideal choice for wound dressing therapies and other biomedical applications.

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Section: Resultsmentioning

confidence: 97%

Section: Morphology Of Nir Led Light-cured Hydrogelsmentioning

confidence: 96%

Gold Nanorods Function as Near-Infrared Light-Activated Microheaters for In Situ Curing of Injectable Hydrogel Therapies

Pruksawan

Chee

Wang

et al. 2023

ACS Appl. Polym. Mater.

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“…Considering the abovementioned circumstances and previous experience on the application of poly(ethylene glycol) diacrylate (PEGDA) and gelatin methacrylate (GelMA) for preparation of matrices for 3D cell culturing [ 51 , 52 ] we made and attempted to use such macromolecules as crosslinkers for intensification of the inter-particle interaction. The schemes of cross-linking in these cases are shown on Figure 7 B,C.…”

Section: Resultsmentioning

confidence: 99%

Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering

et al. 2023

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Different parts of bones possess different properties, such as the capacity for remodeling cell content, porosity, and protein composition. For various traumatic or surgical tissue defects, the application of tissue-engineered constructs seems to be a promising strategy. Despite significant research efforts, such constructs are still rarely available in the clinic. One of the reasons is the lack of resorbable materials, whose properties can be adjusted according to the intended tissue or tissue contacts. Here, we present our first results on the development of a toolbox, by which the scaffolds with easily tunable mechanical and biological properties could be prepared. Biodegradable poly(lactic acid) and nanocrystalline cellulose methacrylated particles were obtained, characterized, and used for preparation of three-dimensional scaffolds via cryogelation and 3D printing approaches. The composition of particles-based ink for 3D printing was optimized in order to allow formation of stable materials. Both the modified-particle cytotoxicity and the matrix-supported cell adhesion were evaluated and visualized in order to confirm the perspectives of materials application.

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“…Next, the mixtures were photo-cross-linked, extracted, and lyophilized, see Figure . Upon irradiation of methacrylate-functionalized polymers in the presence of photoinitiator, the methacrylate groups polymerize via an addition-type reaction forming polymethacrylate cross-links, and thus a network is formed. , …”

Section: Results and Discussionmentioning

confidence: 99%

Hybrid Networks of Hyaluronic Acid and Poly(trimethylene carbonate) for Tissue Regeneration

et al. 2022

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To improve the mechanical performance of hyaluronic acid (HA)-based hydrogels, we prepared novel hybrid hydrogels consisting of hydrophilic HA and hydrophobic poly(trimethylene carbonate) (PTMC). Both polymers were functionalized with methacrylic anhydride, yielding HAMA and PTMC-tMA. Hybrid networks with different ratios of PTMC-tMA:HAMA were prepared by photo-cross-linking, using DMSO pH 2.7 as a common solvent for both macromers. The hybrid networks had high gel contents. The hydrophilicity of the networks increased with increasing HAMA content. The networks consisted of the intended amounts of both macromers. The suture retention strength and compression modulus of the networks increased with increasing PTMC-tMA content. While the 100% HAMA network could not be sutured, the 50:50 PTMC-tMA:HAMA network had a suture retention strength of 5.3 N/mm. This is comparable to that of natural vascular tissues. Also the compression modulus (867 kPa) was significantly higher than that of the 100% HAMA network (13 kPa). Moreover, the networks were compatible with human mesenchymal stem cells. In conclusion, these resilient PTMC-tMA:HAMA networks are promising new biomaterials for tissue regeneration.

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Hybrid Hydrogels Based on Methacrylate-Functionalized Gelatin (GelMA) and Synthetic Polymers

Cited by 13 publications

References 92 publications

Gold Nanorods Function as Near-Infrared Light-Activated Microheaters for In Situ Curing of Injectable Hydrogel Therapies

Gold Nanorods Function as Near-Infrared Light-Activated Microheaters for In Situ Curing of Injectable Hydrogel Therapies

Poly(lactic acid) and Nanocrystalline Cellulose Methacrylated Particles for Preparation of Cryogelated and 3D-Printed Scaffolds for Tissue Engineering

Hybrid Networks of Hyaluronic Acid and Poly(trimethylene carbonate) for Tissue Regeneration

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