Hybrid Nanoparticles for Detection and Treatment of Cancer

Sailor, Michael J.; Park, Ji-Ho

doi:10.1002/adma.201200653

Cited by 439 publications

(311 citation statements)

References 291 publications

(311 reference statements)

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“…Optimizing hybrid multifunctional nanomaterials is a nontrivial undertaking, subject to many and varied considerations, which often requires adoption of design compromises (11). In contrast, we propose a multifunctional agent with emergent properties arising from a simple synergistic design, which enhanced the performance of its constituent components.…”

Section: Resultsmentioning

confidence: 99%

“…These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12,13). However, these systems usually accumulate the specific functionalities of their component modules through multiple steps in their synthetic processes, thereby adding complexity at the expense of performance (11). Furthermore, certain functionalities are intrinsically difficult to combine, directing research efforts toward optimizing tradeoffs.…”

mentioning

confidence: 99%

“…Recently, new emphasis has been placed on hybrid NP systems, where multiple nanomaterials are assembled to create multimodal systems that exhibit the combined qualities of the component modules (9)(10)(11). These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12,13).…”

mentioning

confidence: 99%

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Gold–silica quantum rattles for multimodal imaging and therapy

Hembury

Chiappini

Bertazzo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

111

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Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell's central cavity. This "quantum rattle" structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.nanomedicine | hybrid nanoparticle | cancer nanotechnology | gold quantum dots | mesoporous silica A lthough gold's potential in nanotechnology has been recognized for many decades (1, 2), new insights into the unique properties of gold nanoparticles (NPs) of less than 2 nm have just recently started to emerge (3, 4). Such extremely small gold NPs could be transformative for a broad set of applications ranging from energy production and storage to catalysis and health care (3). As the size of gold NPs decreases below 2 nm, the quantization of their conduction band leads to molecule-like properties (3). These quantum-sized gold NPs (or gold quantum dots, AuQDs) absorb light in the near-infrared (NIR) biological window (650-900 nm) (2) and convert it into photons and heat (5). Furthermore, whereas bulk gold is diamagnetic, some AuQDs exhibit magnetic properties (4, 6). However, the clear therapeutic and imaging potential of AuQDs in vivo has been undermined by their unfavorable biointeractions and lack of stability in aqueous solvents (5, 7). In biological environments AuQDs tend to aggregate rapidly, reverting to larger gold nanoparticles (AuNPs) (8) and/or bind to protein, which negatively affects their cytotoxicity (7). To retain their advantages, AuQDs require a protective, stabilizing framework that allows proficient biological interactions.Recently, new emphasis has been placed on hybrid NP systems, where multiple nanomaterials are assembled to create multimodal systems that exhibit the combined qualities of the component modules (9-11). These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12, 13). However, these systems usually accumulate the specific functionalities of their component modules through multiple steps in their ...

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Gold–silica quantum rattles for multimodal imaging and therapy

Hembury

Chiappini

Bertazzo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

111

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“…Particularly, gold and carbon nanomaterials whose hyperthermal effects are triggered upon irradiation by noninvasive, deep-penetrating nearinfrared light (NIR) have been widely explored as efficient agents for photothermal therapy [34][35][36]204]. Drugs bound to the large surface area or encapsulated in the interior of nanomaterials [205,206] can be released in a controllable manner [33] when hyperthermia is induced. Moreover, nanoscale carriers can cross a tumor endothelium and passively accumulate in tumors owing to the leaky blood vessels and poor lymphatic drainage [207,208].…”

Section: Combined Photothermal and Chemotherapymentioning

confidence: 99%

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp

Shim

Heo

et al. 2016

Advanced Drug Delivery Reviews

440

258

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a b s t r a c t a r t i c l e i n f oThe dynamic and versatile nature of diseases such as cancer has been a pivotal challenge for developing efficient and safe therapies. Cancer treatments using a single therapeutic agent often result in limited clinical outcomes due to tumor heterogeneity and drug resistance. Combination therapies using multiple therapeutic modalities can synergistically elevate anti-cancer activity while lowering doses of each agent, hence, reducing side effects. Co-administration of multiple therapeutic agents requires a delivery platform that can normalize pharmacokinetics and pharmacodynamics of the agents, prolong circulation, selectively accumulate, specifically bind to the target, and enable controlled release in target site. Nanomaterials, such as polymeric nanoparticles, gold nanoparticles/cages/shells, and carbon nanomaterials, have the desired properties, and they can mediate therapeutic effects different from those generated by small molecule drugs (e.g., gene therapy, photothermal therapy, photodynamic therapy, and radiotherapy). This review aims to provide an overview of developing multi-modal therapies using nanomaterials ("combo" nanomedicine) along with the rationale, up-to-date progress, further considerations, and the crucial roles of interdisciplinary approaches.

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“…Gold nanoparticles (AuNPs) can be used as probes and they have recently attracted a lot of attention in biomedical research due to their chemically inert nature and remarkable optical properties. AuNPs have been utilised in many applications such as biochemical sensing [1], drug and gene delivery [2,3]. The rich optical properties of AuNPs arise from their ability to localise surface plasmons.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes

Huefner

Septiadi

Wilts

et al. 2014

Methods

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Understanding uptake of nanomaterials by cells and their use for intracellular sensing is important for studying their interaction and toxicology as well as for obtaining new biological insight. Here, we investigate cellular uptake and intracellular dynamics of gold nanoparticles and demonstrate their use in reporting chemical information from the endocytotic pathway and cytoplasm. The intracellular gold nanoparticles serve as probes for surface-enhanced Raman spectroscopy (SERS) allowing for biochemical characterisation of their local environment. In particular, in this work we compare intracellular SERS using non-functionalised and functionalised nanoparticles in their ability to segregate different but closely related cell phenotypes. The results indicate that functionalised gold nanoparticles are more efficient in distinguishing between different types of cells. Our studies 2 pave the way for understanding the uptake of gold nanoparticles and their utilisation for SERS to give rise to a greater biochemical understanding in cell-based therapies.

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Hybrid Nanoparticles for Detection and Treatment of Cancer

Cited by 439 publications

References 291 publications

Gold–silica quantum rattles for multimodal imaging and therapy

Gold–silica quantum rattles for multimodal imaging and therapy

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes

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