Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Apostolos, Rafaela Caroline Rodrigues dos; Andrade, Gracielle Ferreira; Silva, Wellington Marcos da; Gomes, Dawidson de Assis; Miranda, Marcelo Coutinho de; Sousa, Edésia Martins Barros de

doi:10.1111/ijac.13231

Cited by 17 publications

(17 citation statements)

References 49 publications

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“…The drug delivery from hydroxyapatite minimizes the toxicity to other organs reducing the drug concentration in the blood, avoiding repeated dosage of drugs. HAP easily binds to both positive and negative molecules by simple adsorption and is used for delivery of molecules like antibiotics, contraceptives, acetylsalicylic acid, hormones, insulin and anticancer drugs [26][27][28]. The HAP doping/substitution with different kind of elements (Mg, Si, Sr, Eu, Zn, Ce) was proposed as a way to improve the drug loading [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca

Rinaldi

Bruni

et al. 2022

J Inorg Organomet Polym

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In the pharmaceutical market, the need to find effective systems for the efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one of the most promising systems. In this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media with respect to the drug alone. The hybrids formation was demonstrated by SEM/EDS measurements (showing homogeneous distribution of the elements) and FT-IR spectroscopy. The drug was adsorbed onto hydroxyapatite surfaces in amorphous form, as demonstrated by XRPD and its thermal stability was improved due to the absence, in the hybrids, of melting and decomposition peaks typical of the drug. The Sr substitution on Ca sites in hydroxyapatite allows increasing the surface area and pore volume, foreseeing a high capacity of drug loading. The dissolution tests of the hybrid compounds show dissolution rates much faster than the drug alone in different fluids, and also their solubility and wetting ability is improved in comparison to furosemide alone.

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Section: Introductionmentioning

confidence: 99%

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Rocca

Rinaldi

Bruni

et al. 2022

J Inorg Organomet Polym

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“…The first is the use of HAp scaffolds as drug delivery composites. Associated with anti-tumor drugs, such as doxorubicin, cisplatin, and methotrexate (27)(28)(29)(30)(31)(32), the gradual detachment of these molecules in specific places is guaranteed, also allowing the optimal in loco concentration Abbreviations: ADM, Adriamycin; AMPK, Adenylate-activated protein kinase; FeHA, iron-doped hydroxyapatite; HAp, Hydroxyapatite; hBMSCs, human bone mesenchymal stem cells; HeLa cells, cellular lineage commonly used in studies to assess cell proliferation, cytotoxicity and mortality; HepG2, liver cancer cell line (HepG2); INCA, National Cancer Institute; IOHAp, iron oxide (Fe 2 O 3 ) nanoparticles coated with HAp; K7M2-pCl, including osteosarcoma cells (K7M2-pCl); LbL1, one layer-layer-by-layer scaffold produced from collagen, HAp, magnetite and cisplatin; LbL3, three-layer-layer-by-layer scaffold produced from collagen, HAp, magnetite and cisplatin; LbL5, five layer-layer-by-layer scaffold produced from collagen, HAp, magnetite and cisplatin; LbL7, seven-layerlayer-by-layer scaffold produced from collagen, HAp, magnetite and cisplatin; Mag@CaP, iron oxide nanoparticles coated with amorphous calcium phosphate; MC3T3-E1, Cellular adhesion and proliferation potential of the osteoblastic cell line MC3T3-E1; MG-63, human osteosarcoma lineage cells (MG-63); MH, magnetic hyperthermia; MNPs, magnetic nanoparticles; MRI, magnetic resonance imaging; FeHApC, nanohydroxyapatite/collagen; PCR, polymerase chain reaction; PLGA, poly(lactic-co-glycolic acid); Saos-2, human osteosarcoma cellular lineage (Saos-2). of the respective drug, which is sustained for more extended periods, thus avoiding undesirable side effects (33)(34)(35)(36).…”

Section: Introductionmentioning

confidence: 99%

“…The first is the use of HAp scaffolds as drug delivery composites. Associated with anti-tumor drugs, such as doxorubicin, cisplatin, and methotrexate ( 27 – 32 ), the gradual detachment of these molecules in specific places is guaranteed, also allowing the optimal in loco concentration of the respective drug, which is sustained for more extended periods, thus avoiding undesirable side effects ( 33 – 36 ). The second research front focuses on associating HAp with magnetic nanoparticles (MNPs), to guarantee their biocompatibility ( 37 ).…”

Section: Introductionmentioning

confidence: 99%

Calcium Phosphate-Based Bioceramics in the Treatment of Osteosarcoma: Drug Delivery Composites and Magnetic Hyperthermia Agents

Oliveira

Berti

Gasoto

et al. 2021

Front. Med. Technol.

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The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.

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“…HAp exhibits excellent biocompatibility and bioresorbability [ 15 ]. Thus, various DDS carriers using HAp have been reported [ 16 , 17 , 18 , 19 , 20 ]. Tetracycline hydrochloride, an antibiotic, loaded onto porous HAp was composited with polycaprolactone, and the drug-release behavior of the composite was controlled by varying the mixing ratio [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles

et al. 2021

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Poly(lactic acid)/hydroxyapatite (PLA/HAp) core–shell particles are prepared using the emulsification method. These particles are safe for living organisms because they are composed of biodegradable polymers and biocompatible ceramics. These particles are approximately 50–100 nm in size, and their hydrophobic substance loading can be controlled. Hence, PLA/HAp core–shell particles are expected to be used as drug delivery carriers for hydrophobic drugs. In this work, PLA/HAp core–shell particles with a loading of vitamin K1 were prepared, and their drug-loading ability was evaluated. The particles were 40–80 nm in diameter with a PLA core and a HAp shell. The particle size increased with an increase in the vitamin K1 loading. The drug-loading capacity (LC) value of the particles, an indicator of their drug-loading ability, was approximately 250%, which is higher than the previously reported values. The amount of vitamin K1 released from the particles increased as the pH of the soaking solution decreased because the HAp shell easily dissolved under the acidic conditions. The PLA/HAp particles prepared in this work were found to be promising candidates for drug delivery carriers because of their excellent drug-loading ability and pH sensitivity.

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Hybrid polymeric systems of mesoporous silica/hydroxyapatite nanoparticles applied as antitumor drug delivery platform

Cited by 17 publications

References 49 publications

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

New Emerging Inorganic–Organic Systems for Drug-Delivery: Hydroxyapatite@Furosemide Hybrids

Calcium Phosphate-Based Bioceramics in the Treatment of Osteosarcoma: Drug Delivery Composites and Magnetic Hyperthermia Agents

Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core–Shell Particles

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