Hybrid single-source online Fourier transform coherent anti-Stokes Raman scattering/optical coherence tomography

Kamali, Tschackad; Považay, Boris; Kumar, Sunil; Silberberg, Yaron; Hermann, B.; Werkmeister, René M.; Drexler, Wolfgang; Unterhuber, Angelika

doi:10.1364/ol.39.005709

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…The SH output showed no distortion and was diffraction limited, despite the non-Gaussian input fundamental light. This configuration would indeed be applicable for power scaling purposes for practical use, e.g., in multimodal bioimaging applications [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Concept for power scaling second harmonic generation using a cascade of nonlinear crystals

et al. 2015

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light from a tapered laser diode, while avoiding significant thermal effects. Besides constituting the highest SH power yet achieved using a laser diode, this demonstrates that the concept successfully combines the high efficiency of the first stage with the good power handling properties of the subsequent stages. The concept is generally applicable and can be expanded with more stages to obtain even higher efficiency, and extends also to other combinations of nonlinear media suitable for other wavelengths.

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Section: Discussionmentioning

confidence: 99%

“…Uses of titanium sapphire lasers such as the emerging field of single-source multimodal bioimaging [19,20] place high demands on the power of the titanium sapphire laser and, in turn, the power of its pump source.…”

Section: Introductionmentioning

confidence: 99%

Concept for power scaling second harmonic generation using a cascade of nonlinear crystals

et al. 2015

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“…The use of photoacoustic time traces to monitor the TM inside the medium could for instance be advantageously coupled to nonlinear detection, in both backward and forward directions. Furthermore, recent applications of wavefront shaping for optical coherence tomography have demonstrated enhanced penetration depth 42 , with the latter being conveniently coupled with NLM [43][44][45] thus showing that addressing linear feedback can be considerably more advantageous.…”

Section: Discussionmentioning

confidence: 99%

Enhanced nonlinear imaging through scattering media using transmission-matrix-based wave-front shaping

2016

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Despite the tremendous progresses in wavefront control through or inside complex scattering media, several limitations prevent reaching practical feasibility for nonlinear imaging in biological tissues. While the optimization of nonlinear signals might suffer from low signal to noise conditions and from possible artifacts at large penetration depths, it has nevertheless been largely used in the multiple scattering regime since it provides a guide star mechanism as well as an intrinsic compensation for spatiotemporal distortions. Here, we demonstrate the benefit of Transmission Matrix (TM) based approaches under broadband illumination conditions, to perform nonlinear imaging. Using ultrashort pulse illumination with spectral bandwidth comparable but still lower than the spectral width of the scattering medium, we show strong nonlinear enhancements of several orders of magnitude, through thicknesses of a few transport mean free paths, which corresponds to millimeters in biological tissues. Linear TM refocusing is moreover compatible with fast scanning nonlinear imaging and potentially with acoustic based methods, which paves the way for nonlinear microscopy deep inside scattering media.

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“…RS allows for full molecular fingerprinting of tissue offers high specificity. Several variants including non-linear vibrational imaging 82 with different sophisticated laser sources 83,84 and single-laser source approaches [85][86][87] have been proposed, but the main deficit is that real-world applications are often missing due to special treatment of the sample-thin slices of transparent samples with high Raman cross sections to be investigated in transmission or reflection mode. Coherent anti-Stokes Raman scattering efficiently provides images with label-free molecular information from DNA, lipids, proteins, and collagen.…”

Section: Non-linear Optical Microscopy and Spectroscopy: Subcellular Biochemical And Metabolicmentioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

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Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

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Hybrid single-source online Fourier transform coherent anti-Stokes Raman scattering/optical coherence tomography

Cited by 12 publications

References 28 publications

Concept for power scaling second harmonic generation using a cascade of nonlinear crystals

Concept for power scaling second harmonic generation using a cascade of nonlinear crystals

Enhanced nonlinear imaging through scattering media using transmission-matrix-based wave-front shaping

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

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