Recent developments in arrhythmology have enabled the use of new
devices, such as subcutaneous implantable cardioverter-defibrillators
(s-ICD), and the comeback of older strategies, such as His-Bundle pacing
(HBP) in clinical practice, alongside the use of thoroughly proven
therapies such as cardiac resynchronization therapy (CRT), e.g. with
His-Optimized CRT (HOT-CRT). However, interplay between these new and
older techniques is not always clear. We report the first-in-human case
of biventricular pacemaker (CRT-P) implantation with HOT-CRT in an s-ICD
patient. Paced QRS morphology was similar to the spontaneous morphology,
albeit shorter. Correct QRS identification by the s-ICD was confirmed
both intra-procedurally and post-procedurally.