Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

Abstract

Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g−1 for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window.

Colon Delivery of Nutraceutical Ingredients by Food-Grade Polymeric Systems: An Overview of Technological Characterization and Biological Evaluation

“…The extensive literature available proposes different protocols (direct beaker dissolution, dissolver dissolution, dialysis method, etc.) for colon-targeted DDS [65,[113][114][115]. Therefore, in order to properly compare release profiles different variables must be considered including, intrinsic properties of the system (shape, size, rheology/viscosity, nature of components and their interactions, if any, production procedures, %EE and/or %DL and release mechanism, etc.…”

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

“…Chitosan is a natural copolymer having good biocompatibility, antibacterial activity, and biodegradability [ 59 ]. Chitosan improves the mucosal adhesion properties and gel strength of poloxamer gels because chitosan has positively charged amine residues that facilitate interaction with the gel solution to provide the drug with proper mechanical and mucosal adhesion properties [ 60 ].…”

Controlled-Release Materials for Remediation of Trichloroethylene Contamination in Groundwater

“…Starting from the 1990s, oral controlled-release formulations have become a significant research focus in the pharmaceutical field due to their mechanism of once-daily dosing, controlled, targeted, and timed release [23,24]. Currently, controlled-release materials have found widespread use in both the agricultural [25] and pharmaceutical [26] fields. However, due to factors such as site complexity [27,28] and economic considerations, research on controlled-release materials in the domain of groundwater pollution control has predominantly remained at the level of laboratory theoretical studies.…”