2020
DOI: 10.3390/polym12040914
|View full text |Cite
|
Sign up to set email alerts
|

Hybrid Vesicle Stability under Sterilisation and Preservation Processes Used in the Manufacture of Medicinal Formulations

Abstract: Sterilisation and preservation of vesicle formulations are important considerations for their viable manufacture for industry applications, particular those intended for medicinal use. Here, we undertake an initial investigation of the stability of hybrid lipid-block copolymer vesicles to common sterilisation and preservation processes, with particular interest in how the block copolymer component might tune vesicle stability.We investigate two sizes of polybutadiene-block-poly(ethylene oxide) polymers (PBd 12… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
5
1
1

Relationship

2
5

Authors

Journals

citations
Cited by 7 publications
(7 citation statements)
references
References 51 publications
0
7
0
Order By: Relevance
“…Despite the pro-stability high polymeric content of the current niosome formulation, the ice crystals formed during freezing might damage the niosome vesicles, resulting in their rupture, aggregation, or expansion (Seneviratne et al., 2020 ). A similar change in physical characteristics was seen in liposomal vesicles that underwent freezing at −22 °C (Costa et al., 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…Despite the pro-stability high polymeric content of the current niosome formulation, the ice crystals formed during freezing might damage the niosome vesicles, resulting in their rupture, aggregation, or expansion (Seneviratne et al., 2020 ). A similar change in physical characteristics was seen in liposomal vesicles that underwent freezing at −22 °C (Costa et al., 2014 ).…”
Section: Discussionmentioning
confidence: 99%
“…A common approach to exploit this fact is to use Triton-X at concentrations ranging from 0.03–1% to release the cargo and evaluate the encapsulation efficiency. 1,46,51,61,75,76,78,79,93…”
Section: Stabilitymentioning
confidence: 99%
“…In January 2020, for example, Caitlin visited the lab to observe doctoral researcher Rashmi Seneviratne's work with a cryo-electron microscope (see Fig. 1), examining frozen samples containing thousands of tiny artificial structures called vesicles [8]. At the same time, other members of the group were uploading images to a shared folder to illustrate the scale of their research.…”
Section: Process and Philosophymentioning
confidence: 99%