Hybrid vesicles co-assembled from anionic graft copolymer and metal ions for controlled drug release

Li, Guiying; Mei, Qi; Yu, Ning; Liu, Xunyong

doi:10.1016/j.cej.2014.10.029

Cited by 41 publications

(11 citation statements)

References 28 publications

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“…Another effort that was made using PNIPAAm was to prepare a graft copolymer from sodium alginate- g - PNIPAAm (ALG- g - PNIPAAm) with multivalent metal ions (Ca 2+ and Al 3+ ) and 5-fluorouracil (5-FU) anticancer drug. 211 In this study, Guiying Li and his group prepared a hollow structure with a size of about 100 nm. The swollen polymer chains formed the neutral part, and the complex bonds between the sodium alginate chains and the metal ions imparted stability to the micelles.…”

Section: Temperature Responsive Nanocarriers For Cargo Deliverymentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

359

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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Section: Temperature Responsive Nanocarriers For Cargo Deliverymentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

359

212

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7] The distinguished comprehensive performance of these materials is beneficial for widespread applications, including microelectronic packing, 8,9 aerospace, 10 adhesives, 11 radiation shielding, [12][13][14] and advanced composite matrices. [15][16][17][18] Nevertheless, the course of solidifying pure phthalonitriles has been considerably slow. 19 Therefore, solidifying agents, such as acids, amines, and their salts, have been used to promote the curing process.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and properties of a novel high-temperature vinylpyridine-based phthalonitrile polymer

Wang

Zhang

et al. 2018

High Performance Polymers

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A novel vinylpyridine-based phthalonitrile monomer, 2,6-bis[3-(3,4-dicyanophenoxy)styryl]pyridine (BDSP), was resoundingly produced by a nucleophilic substitution reaction of 2,6-bis(3-hydroxystyryl)pyridine with 4-nitrophthalonitrile in the presence of potassium carbonate. The chemical structure of the synthesized BDSP was confirmed by proton (1H) and carbon (12C) nuclear magnetic resonance (NMR) as well as Fourier transform infrared (FTIR) analysis. The curing behavior of BDSP was investigated by FTIR and differential scanning calorimetry (DSC) analyses. The resin showed a low complex viscosity in the wide processing window between the monomer melting temperature and the curing temperature of the polymer, as discovered by rheological analysis. In addition, the properties of the polymer were studied by thermal gravimetric analysis (TGA) and dynamic mechanical analysis (DMA). Based on the test results, the BDSP polymer demonstrated superior processing performance, excellent thermal stability, outstanding mechanical properties, and low water uptake, and these advanced performance characteristics are critical to many fields.

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“…The temperature sensitivity of the MSN-SS-Fc@β-CD-PNIPAM composite nanoparticles was proven by the changes in their transmittance at different temperatures from V-1100D spectrophotometer (Shanghai Meipuda instrument Co. Ltd, Shanghai, China). Hydrophilic PNIPAM chains obtain hydrophobicity when their temperature is higher than the lower critical solution temperature (LCST) [27,28]. As shown in Figure 5A, the transmittance of the β-CD-PNIPAM star polymer and complex nanoparticles was all stable at room temperature.…”

Section: Resultsmentioning

confidence: 99%

Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles

Guo

et al. 2019

Polymers

Self Cite

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A temperature, glutathione (GSH), and H2O2 multi-responsive composite nanocarrier (MSN-SS-Fc@β-CD-PNIPAM) based on β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared. The surface of the mesoporous silica was first modified by ferrocene (Fc) via a disulfide bond (–SS–) to form an oxidizing and reducing site and then complexed with a β-CD-PNIPAM star shaped polymer through host–guest interactions as a nano-valve to provide temperature responsive characteristics. The structure and properties of the complex nanoparticles were studied by FTIR, TGA, EDS, Zeta potential, and elemental analysis. Doxorubicin (DOX) and Naproxen (NAP), as model drugs, were loaded into nanocarriers to assess drug loading and release behaviour. The release of drugs from nanocarriers was enhanced with an increase of the GSH, H2O2 concentration, or temperatures of the solution. The kinetics of the release process were studied using different models. This nanocarrier presents successful multi-stimuli responsive drug delivery in optimal stimuli and provides potential applications for clinical treatment.

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Hybrid vesicles co-assembled from anionic graft copolymer and metal ions for controlled drug release

Cited by 41 publications

References 28 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Synthesis and properties of a novel high-temperature vinylpyridine-based phthalonitrile polymer

Multi-Responsive Nanocarriers Based on β-CD-PNIPAM Star Polymer Coated MSN-SS-Fc Composite Particles

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