Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells

Giordano, Flavia; Corvino, Angela; Scognamiglio, Antonia; Citi, Valentina; Gorica, Era; Fattorusso, Caterina; Persico, Marco; Caliendo, Giuseppe; Fiorino, Ferdinando; Magli, Elisa; Perissutti, Elisa; Santagada, Vincenzo; Severino, Beatrice; Pavese, Rocco Carmelo; Petti, Francesco; Martelli, Alma; Calderone, Vincenzo; Frecentese, Francesco

doi:10.1016/j.ejmech.2021.113517

Cited by 15 publications

(14 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Important inhibitory effects on mast cell degranulation have been observed, due to a reduction in the release of β-hexosaminidase which was more effective compared to the corresponding native drugs. Compounds 92 and 93 established an important membrane hyperpolarization of BSMCs and have been shown to be more effective than the reference compound NS1619 [ 258 ].…”

Section: H 2 S Donors and Diseasesmentioning

confidence: 99%

H2S Donors and Their Use in Medicinal Chemistry

Magli¹,

Perissutti²,

Santagada³

et al. 2021

Biomolecules

Self Cite

View full text Add to dashboard Cite

Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important role in many physiological and pathological processes in mammalian tissues, with the same importance as two others endogenous gasotransmitters such as NO (nitric oxide) and CO (carbon monoxide). Endogenous H2S is involved in a broad gamut of processes in mammalian tissues including inflammation, vascular tone, hypertension, gastric mucosal integrity, neuromodulation, and defense mechanisms against viral infections as well as SARS-CoV-2 infection. These results suggest that the modulation of H2S levels has a potential therapeutic value. Consequently, synthetic H2S-releasing agents represent not only important research tools, but also potent therapeutic agents. This review has been designed in order to summarize the currently available H2S donors; furthermore, herein we discuss their preparation, the H2S-releasing mechanisms, and their -biological applications.

show abstract

Section: H 2 S Donors and Diseasesmentioning

confidence: 99%

H2S Donors and Their Use in Medicinal Chemistry

Magli¹,

Perissutti²,

Santagada³

et al. 2021

Biomolecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…On this ground, H 2 S‐releasing agents (also named H 2 S donors) seem to be adequate for either mimicking the endogenous H 2 S generation under physiological conditions, or replenishing additional H 2 S for both diagnostic and therapeutical purposes. During the past years, substantial endeavor has been made to develop various H 2 S donors, and a number of H 2 S donors with different releasing rates and mechanisms have been reported 101,105–125 . H 2 S donors, regarded as the exogenous suppliers of H 2 S, could be employed as the ideal candidates for the treatment of diseases whose H 2 S‐associated networks might be short‐circuited.…”

Section: Introductionmentioning

confidence: 99%

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Song

Zhao

et al. 2022

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

“…These steroids possess anti-inflammatory, antiseptic, antishock effects with minimal prominent adverse effects. [90] Guo et al used HA to construct a rapidly dissolving microneedles patch to enhance the transdermal delivery of BSP-BDP for the treatment of oral ulcers. [91] As shown in Figure 5a, BSP-BDP@MNs exhibited sufficient mechanical strength to penetrate the mucous membrane of the rat tongue abdomen with an insertion depth of about 207 ± 3 μm through a straightforward preparation process.…”

Section: Oral Ulcermentioning

confidence: 99%

“…These steroids possess anti‐inflammatory, antiseptic, antishock effects with minimal prominent adverse effects. [ 90 ] Guo et al. used HA to construct a rapidly dissolving microneedles patch to enhance the transdermal delivery of BSP‐BDP for the treatment of oral ulcers.…”

Section: Microneedles For Oral Disease Treatmentmentioning

confidence: 99%

Advances in the Application of Microneedles in the Treatment of Local Organ Diseases

Li,

Ge,

Lin

et al. 2023

Small

View full text Add to dashboard Cite

In recent years, microneedles (MNs) have attracted a lot of attention due to their microscale sizes and high surface area (500–1000 µm in length), allowing pain‐free and efficient drug delivery through the skin. In addition to the great success of MNs based transdermal drug delivery, especially for skin diseases, increasing studies have indicated the expansion of MNs to diverse nontransdermal applications, including the delivery of therapeutics for hair loss, ocular diseases, and oral mucosal. Here, the current treatment of hair loss, eye diseases, and oral disease is discussed and an overview of recent advances in the application of MNs is provided for these three noncutaneous localized organ diseases. Particular emphasis is laid on the future trend of MNs technology development and future challenges of expanding the generalizability of MNs.

show abstract

Hybrids between H2S-donors and betamethasone 17-valerate or triamcinolone acetonide inhibit mast cell degranulation and promote hyperpolarization of bronchial smooth muscle cells

Cited by 15 publications

References 53 publications

H2S Donors and Their Use in Medicinal Chemistry

H2S Donors and Their Use in Medicinal Chemistry

Progress and perspective on hydrogen sulfide donors and their biomedical applications

Advances in the Application of Microneedles in the Treatment of Local Organ Diseases

Contact Info

Product

Resources

About