Hydrated Electron Reactions with Thiols in Acidic Aqueous Solutions

Tung, Tzu-Lin; Kuntz, Robert R.

doi:10.2307/3573681

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…The sulfhydryl group also reacts rapidly with the hydrated electron; reported rate constants vary from o-oi to 2x io 10 M~X sec" 1 (Braams, 1966;Karmann et al 1969;Hoffman & Hayon, 1973;Tung & Kuntz, 1973). Reaction rates depend upon the compound under study, and are sensitive to pH.…”

Section: Cooh Coohmentioning

confidence: 99%

Applications of Pulse Radiolysis to Protein Chemistry

Klapper¹,

Faraggi²

1979

Quart. Rev. Biophys.

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Since its introduction, pulse radiolysis has been an important technique for examining the properties of organic and inorganic radicals, and for enumerating those reactions responsible for cellular damage by ionizing radiation. Biochemists, and biophysicists outside the area of radiation biology appear, perhaps for historical reasons, to have an incomplete appreciation of the technique's potential. Protein chemists in particular, have been only dimly aware of the numerous reports of, and the significant results obtained from pulse radiolysis studies of proteins. Our purpose here is to bring some of these results together in order to emphasize the power and usefulness of pulse radiolysis experiments both for elucidating enzyme reaction mechanisms, and for gaining information on the structure of proteins in aqueous solutions. Reviews containing related, or in part the same material to be covered here have appeared previously; for example, Land (1970), Adams et al. (1972a), Shafferman & Stein (1975), Adams & Wardman (1977). This review updates these earlier works, but more importantly approaches the topic of protein pulse radiolysis with a different emphasis.

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Section: Cooh Coohmentioning

confidence: 99%

Applications of Pulse Radiolysis to Protein Chemistry

Klapper¹,

Faraggi²

1979

Quart. Rev. Biophys.

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“…Hence we exclude the possibility that the high coverage layers observed with MUA are the result of thiyl radical addition to the graphite surface. On the other hand, it has been demonstrated that RSH molecules undergo RSH cleavage leading to the formation of alkyl radicals under reductive attack by either solvated electrons , or hydrogen atoms − according to the following reactions: normalH• + RSH → normalR• + normalH 2 normalS normale − + RSH → normalR• + HS − …”

Section: Discussionmentioning

confidence: 99%

Photochemically Triggered Alkylthiol Reactions on Highly Ordered Pyrolytic Graphite

et al. 2011

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“…These percentages lic in the range 92 to 98%, showing that the relationship holds to a good approximation. Thc small deficiencies in the yields arc expected in view of the probable occurrence of radical disproportion reactions such as [24] and [26] The quantity r./p is equal to G(penSSSpen) divided by G(tota1 pens. radicals formed), which can be assumed to be 6.6 per 100 eV.…”

Section: I~erzsspen Arzcl ~Xtzsss~~etzmentioning

confidence: 99%

Product yields and mechanism of penicillamine radiolysis at pH 5

Goyal¹

1976

Can. J. Chem.

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Can. J. Chem. 54, 1938 (1976. The major products from the radiolysis of penicillamine in N20-saturated solutions a t p H 5 are penicillamine disulfide, penicillamine trisulfide, and valine with yields of 2.0, 1.2, and 1.5 molecules per 100 eV in lo-' M solutions and 1.8, 0.94, and 0.60 molecules per 100 eV in 10-3 M solutions respectively. These yields remain essentially the same when the major attacking radical is changed from .OH to . C H 2 0 H , .Br2-or .(CNS)?-, and it is concluded that all four species produce predominantly pens. radicals on attacking penicillamine. The formation of trisulfide and an equivalent amount of valine is attributed to secondary reactions of pens. radicals and discussed in the light of recent pulse radiolysis experiments and other work.In deaerated solutions hydrogen and H2S were observed in significant yields and the valine yield increased. These observations can be accounted for quantitatively by the reactions: [To] . The yields of minor (G < 0.5 molecules per 100 eV) products like NH3 and CH2=C(CH3)-CH(NH,+)COO-indicated that fragmentation of p e n and other secondary radicals from penSH was more important than for cys. and other radicals from cysSH.GREESH CHAND GOYAL et DAVID ANTHONY ARMSTRONG. Can. J. Chem. 54, 1938Chem. 54, (1976 Les produits majeurs de la radiolyse de la pinicillamine dans des solutions saturees de NzO 2 un p H de 5 sont le disulfure de ~Cnicillamine, le trisulfure de pCnicillamine et la valine avec des [Traduit par le journal]

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Hydrated Electron Reactions with Thiols in Acidic Aqueous Solutions

Cited by 9 publications

References 8 publications

Applications of Pulse Radiolysis to Protein Chemistry

Applications of Pulse Radiolysis to Protein Chemistry

Photochemically Triggered Alkylthiol Reactions on Highly Ordered Pyrolytic Graphite

Product yields and mechanism of penicillamine radiolysis at pH 5

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