Hydration and partial compressibility of biological compounds

Solvent effects on the molecular structures of crude gliadins as revealed by density and ultrasound velocity measurements

“…Generally, apparent specific quantities are calculated from the apparent molar ones divided by the molecular weight, M (Kharakoz and Sarvazyan, 1993;Chalikian et al, 1994a;Chalikian et al, 1994b;Taulier and Chalikian, 2002).…”

“…Thus, from equation 7, the value of β S is obtained as (Gekko and Noguchi, 1974;Gekko and Noguchi, 1979;Sarvazyan et al, 1979;Chavez et al, 1985;Gekko and Hasegawa, 1986;Sarvazyan, 1991;Chalikian et al, 1992;Kharakoz and Sarvazyan, 1993;Chalikian et al, 1994a;McClements, 1995;Tikhonov et al, 1995;Paci and Marchi, 1996;Hianik et al, 1997;Pinfield and Povey, 1997;Povey, 1997;Heremans and Smeller, 1998;Povey, 1998;Burakowski and Gliński, 2007;Raman et al, 2007).…”

“…Like the application of the partial specific volume of the proteins in a solution, the so-called partial specific compressibility coefficient is introduced for understanding the compressible or elastic properties of ideally isolated protein molecules in solution (Millero et al, 1976;Chalikian et al, 1993;Chalikian et al, 1994a). The partial specific compressibility coefficient can be adiabatic or isothermal, depending on the conditions under which it is measured.…”

“…He stated that such differential measurements were one or two orders of magnitude more precise than the absolute measurements. Besides, the concentration increment of the compressible properties also provides important information on the molecular structure of proteins in solution (Sarvazyan, 1991;Chalikian et al, 1992;Chalikian et al, 1993;Chalikian et al, 1994a;Chalikian et al, 1994b;Povey, 1997;Kharakoz and Bychkova, 1997;Chalikian, 1998;Hianik et al, 1997;Taulier et al, 2005).…”

“…where the subscripts M and I represent intrinsic molecular and hydration contributions (Kharakoz, 1991;Sarvazyan, 1991;Kharakoz and Sarvazyan, 1993;Chalikian et al, 1994a;Chalikian et al, 1994b;Chalikian, 1998;Chalikian and Breslauer, 1998;Taulier and Chalikian, 2002). Since the intrinsic volume of a protein contains two parts, i.e., the contact surface, which is the part of the Van der Waals surface contacting the solvent molecules; and the re-entrant surface, which connects the contact surfaces when one solvent molecule is contacting more than one atom of a protein (Connolly, 1983;Totrov and Abagyan, 1996;Hayryan et al, 2005).…”