Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms

Paredes, Adrián; Palacios, Javier; Quispe, Cristina; Nwokocha, Chukwuemeka R.; Morales, Glauco; Kuzmicic, Jovan; Cifuentes, Fredi

doi:10.1016/j.jep.2016.07.008

Cited by 25 publications

(34 citation statements)

References 18 publications

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“…Aerial parts of several species of Senecio natives of the north of Chile are widely employed in the folk medicine as remedy for the altitudinal sickness [2][3][4]. In a continuation of a phytochemical research on Senecio species, which grow on the western flank of the Andes in northern Chile (ca 4000 m) [5][6][7][8], we report the isolation of a new eremophylane sesquiterpenoid from Senecio adenophyllus Meyen & Walp.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C₁₅H₂₄O₃

Morales

Paredes

Brito

et al. 2017

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Discussionmentioning

confidence: 99%

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C₁₅H₂₄O₃

Morales

Paredes

Brito

et al. 2017

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Vascular reactivity was evaluated according to Cifuentes, Paredes et al 19 , 40 . Following the sacrifice of the animals by cervical dislocation, the aorta was separated and transferred to a Krebs–Ringer bicarbonate buffer (KRB) solution at 4 °C, (mM): 4.2 KCl, 1.19 KH 2 PO 4 , 120 NaCl, 25 NaHCO 3 , 1.2 MgSO 4 , 1.3 CaCl 2 , and 5 D-glucose (pH7.4).…”

Section: Methodsmentioning

confidence: 99%

Hypotensive and antihypertensive effects of an aqueous extract from Guinep fruit (Melicoccus bijugatus Jacq) in rats

Nwokocha

Gordon

Palacios

et al. 2020

Sci Rep

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Melicoccus bijugatus Jacq (Mb) has been reported to have cardiovascular modulatory effects. In this study, we evaluated the antihypertensive effects and mechanism of action of Mb on NG-Nitro-l-arginine Methyl Ester (l-NAME) and Deoxycorticosterone Acetate (DOCA) rat models. Aqueous extract of Mb fruit (100 mg/kg) was administered for 6 weeks to rats by gavage and blood pressure was recorded. Effects of the extract on vascular reactivity was evaluated using isolated organ baths, and tissues were collected for biochemical and histological analysis. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were significantly (P < 0.05) reduced with extract (100 mg/kg) administration and treatment compared to the hypertensive models. Mb (100 µg/mL) reduced the vascular contractility induced by phenylephrine (PE), and caused a dose-dependent relaxation of PE-induced contraction of aortic vascular rings. The vasorelaxation properties seemed to be endothelium dependent, as well as nitric oxide (NO) and guanylyl cyclase, but not prostaglandin dependent. Histomicrograph of transverse sections of the ventricles from the Mb group did not show abnormalities. The extract significantly (P < 0.05) reduced an l-NAME induced elevation of cardiac output and Creatine Kinase Muscle-Brain (CKMB), but had no significant impact on the activities of arylamine N-acetyltransferase. In conclusion, Mb significantly decreased blood pressure in hypertensive models. The extract possesses the ability to induce endothelium dependent vasodilation, which is dependent on guanylyl cyclase but not prostaglandins.

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“…Vascular reactivity was evaluated in the aortic rings according to Paredes et al [ 25 ]. Rats were sacrificed by cervical dislocation.…”

Section: Methodsmentioning

confidence: 99%

Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2‐(4‐Hydroxyphenyl) Amino‐1,4‐naphthoquinone in Rats

Palacios

Fonseca

Ayavire

et al. 2018

Oxidative Medicine and Cellular Longevity

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Quinone derivatives like 2-(4-hydroxyphenyl) amino-1,4-naphthoquinone (Q7) are used as antitumor agents usually associated with adverse effects on the cardiovascular system. The objective of this study was to evaluate the cardioprotective effect of ascorbate on Q7-induced cardiovascular response in Wistar rats. In this study, blood pressure, vascular reactivity, and intracellular calcium fluxes were evaluated in cardiomyocytes and the rat aorta. We also measured oxidative stress through lipid peroxidation (TBARS), superoxide dismutase- (SOD-) like activity, and H2O2 generation. Oral treatment of rats with ascorbate (500 mg/kg) for 20 days significantly (p < 0.05) reduced the Q7-induced increase (10 mg/kg) in blood pressure and heart rate. The preincubation with ascorbate (2 mM) significantly (p < 0.05) attenuated the irregular beating of the atrium induced by Q7 (10−5 M). In addition, ascorbate induced endothelial vasodilation in the presence of Q7 in the intact aortic rings of a rat and reduced the cytosolic calcium levels in vascular smooth muscle cells. Ascorbate also reduced the Q7-induced oxidative stress in vivo. Ascorbate also attenuated Q7-induced SOD-like activity and increased TBARS levels. These results suggest a cardioprotective effect in vivo of ascorbate in animals treated orally with a naphthoquinone derivative by a mechanism involving oxidative stress.

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Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms

Cited by 25 publications

References 18 publications

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C₁₅H₂₄O₃

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C₁₅H₂₄O₃

Hypotensive and antihypertensive effects of an aqueous extract from Guinep fruit (Melicoccus bijugatus Jacq) in rats

Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2‐(4‐Hydroxyphenyl) Amino‐1,4‐naphthoquinone in Rats

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Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms

Cited by 25 publications

References 18 publications

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C15H24O3

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C15H24O3

Hypotensive and antihypertensive effects of an aqueous extract from Guinep fruit (Melicoccus bijugatus Jacq) in rats

Ascorbate Attenuates Oxidative Stress and Increased Blood Pressure Induced by 2‐(4‐Hydroxyphenyl) Amino‐1,4‐naphthoquinone in Rats

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Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C₁₅H₂₄O₃

Crystal structure of 1α,11-dihydroxyeremophil-9-en-8-one, C₁₅H₂₄O₃