Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity

Botelho, Ana Flávia Machado; Santos‐Miranda, Artur; Joca, Humberto C.; Mattoso, Cláudio Roberto Scabelo; Oliveira, Marcelo Moizinho; Pierezan, Felipe; Cruz, Jáder Santos; Soto-Blanco, Benito; Melo, Marília Martins

doi:10.1016/j.jep.2017.05.031

Cited by 33 publications

(14 citation statements)

References 20 publications

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“…Similar attempts have been made for the propagation of Carissa carandas using shoot apex and nodal part (Hasmah, Bhatt, & Keng, ; Imran, Begum, Sujatha, & Mallaiah, ; Rai & Misra, ). Some reports are available on in vitro propagation of Rauvolfia serpentina (Sarker, Islam, Islam, Hoque, & Joarder, ) and Nerium oleander (Botelho et al, ; Vila et al, ). Among them, Nerium oleander was propagated for ornamental purpose because some members of this family are garden plants.…”

Section: Micropropagation: a Strategy For Conservation Of Apocynaceaementioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

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Section: Micropropagation: a Strategy For Conservation Of Apocynaceaementioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

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show abstract

“…It is possible that CG affects the heart as it can damage the activity of the ATPase pump as well as the sodium-potassium (NKA) pump, resulting in positive inotropia. As for OLE, it leads to electromechanical disturbances in the heart as a result of inhibition of the Na + / K + pump, in addition to mitochondrial swelling, as well as modulation of the plasma (endo) Ca2 + ATPase without affecting the autonomic nervous system, (Botelho et al, 2017).flower extracts of Nerium oleander found to have larvicidal activity against the larval stage of Anopheles stephensi and Aedes aegypti, Culex quinquefasciatus, (Raveen et al, 2017), Hydroethanolic extracts of N. oleander found to own a toxic effect against Pectinophora gossypiella (Suanders). (Moustafa, Al Shater and Yousef, 2018) The use of nanotechnology increases the efficiency of the plant materials, as it provides an increase in the surface of the particles, thus increasing its activity towards the target pests.…”

Section: Discussionmentioning

confidence: 99%

Insecticidal potential of some plant extracts in nano and normal form on immatures stages of red palm weevil Rhynchophorus ferrugineus

Ali

Mohanny

Mohamed

et al. 2020

SVU-International Journal of Agricultural Sciences

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“…Arrhythmias and electrical conduction disturbances promoted by digitalis derivatives are related to cardiomyocyte dysfunction (Botelho et al, 2017). Oleandrin, a cardiac glycoside derived from the leaves of Nerium indicum, has been shown to induce myocardial damage in vivo and in vitro (Poindexter et al, 2007;Zhou et al, 2019).…”

Section: Terpenoidsmentioning

confidence: 99%

Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica–Induced Cardiotoxicity

Zhou

Cao

et al. 2021

Front. Pharmacol.

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Chinese materia medica (CMM) has been applied for the prevention and treatment of diseases for thousands of years. However, arrhythmia, myocardial ischemia, heart failure, and other cardiac adverse reactions during CMM application were gradually reported. CMM-induced cardiotoxicity has aroused widespread attention. Our review aimed to summarize the risk compounds, preclinical toxicity evaluation, and potential mechanisms of CMM-induced cardiotoxicity. All relevant articles published on the PubMed, Embase, and China National Knowledge Infrastructure (CNKI) databases for the latest twenty years were searched and manually extracted. The risk substances of CMM-induced cardiotoxicity are relatively complex. A single CMM usually contains various risk compounds, and the same risk substance may exist in various CMM. The active and risk substances in CMM may be transformed into each other under different conditions, such as drug dosage, medication methods, and body status. Generally, the risk compounds of CMM-induced cardiotoxicity can be classified into alkaloids, terpenoids, steroids, heavy metals, organic acids, toxic proteins, and peptides. Traditional evaluation methods of chemical drug-induced cardiotoxicity primarily include cardiac function monitoring, endomyocardial biopsy, myocardial zymogram, and biomarker determination. In the preclinical stage, CMM-induced cardiotoxicity should be systematically evaluated at the overall, tissue, cellular, and molecular levels, including cardiac function, histopathology, cytology, myocardial zymogram, and biomarkers. Thanks to the development of systematic biology, the higher specificity and sensitivity of biomarkers, such as genes, proteins, and metabolic small molecules, are gradually applied for evaluating CMM-induced cardiotoxicity. Previous studies on the mechanisms of CMM-induced cardiotoxicity focused on a single drug, monomer or components of CMM. The interaction among ion homeostasis (sodium, potassium, and calcium ions), oxidative damage, mitochondrial injury, apoptosis and autophagy, and metabolic disturbance is involved in CMM-induced cardiotoxicity. Clarification on the risk compounds, preclinical toxicity evaluation, and potential mechanisms of CMM-induced cardiotoxicity must be beneficial to guide new CMM development and post-marketed CMM reevaluation.

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Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity

Cited by 33 publications

References 20 publications

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Insecticidal potential of some plant extracts in nano and normal form on immatures stages of red palm weevil Rhynchophorus ferrugineus

Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica–Induced Cardiotoxicity

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