Hydrocortisone/cyclodextrin complex electrospun nanofibers for a fast-dissolving oral drug delivery system

Çelebioğlu, Aslı; Uyar, Tamer

doi:10.1039/c9md00390h

Cited by 54 publications

(34 citation statements)

References 69 publications

(128 reference statements)

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“…Oral drug delivery is still the preferred route for drug administration, mainly by capsules or tablet form. There are several studies that have produced an oral drug delivery system by means of electrospinning technique [5,78,79]. It's been used for the fabrication of fast-dissolving systems enabled to increase drug bioavailability and safer excipients when compared to common oral administration systems.…”

Section: Oral Drug Delivery Systems Prepared By Electrospinningmentioning

confidence: 99%

“…Nowadays, hundreds of papers exhibit the preparation, synthesis, modification, and functionalization of micro and nanofibers, mainly polymers, blends and composites. These publications include a vast number of electrospun materials for applications such as elastic and flexible electronics [4][5][6][7] magnetics [8,9], energy by producing high-performance membranes for fuel cells, thanks to the capability in sustaining proton conductivity and reduce methanol permeability [10], applications in solid oxide fuel cells electrodes [11,12]. Also, materials fabricated by ES are intensely studied for wastewater treatment such as heavy metal ion adsorption, removal of dye contaminants, water purification, etc.…”

Section: Introductionmentioning

confidence: 99%

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Electrospinning: A promising technique for drug delivery systems

Martínez-Pérez

2020

Reviews on Advanced Materials Science

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In the last years, electrospinning has become a technique of intense research to design and fabricate drug delivery systems (DDS), during this time a vast variety of DDS with mainly electrospun polymers and many different active ingredient(s) have been developed, many intrinsic and extrinsic factor have influence in the final system, there are those that can be attributed to the equipment set up and that to the physical-chemical properties of the used materials in the fabrication of DDS. After all, this intense research has generated a great amount of DDS loaded with one or more drugs. In this manuscript a review with the highlights of different kind of systems for drug delivery systems is presented, it includes the basic concepts of electrospinning, types of equipment set up, polymer/drug systems, limitations and challenges that need to be overcome for clinical applications.

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Section: Oral Drug Delivery Systems Prepared By Electrospinningmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrospinning: A promising technique for drug delivery systems

Martínez-Pérez

2020

Reviews on Advanced Materials Science

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“…Over the past few decades, nanofibers have shown immense potential in a broad range of applications such as energy storage [ 1 , 2 , 3 ], environmental remediation [ 4 ], agriculture [ 5 ], and filtration [ 6 ]. More relevant to this study, they are also useful in a variety of biomedical applications including biosensing [ 7 ], diagnosis [ 8 , 9 ], drug delivery [ 10 , 11 , 12 ], wound dressing [ 13 , 14 , 15 ], regenerative medicine [ 16 , 17 ], and scaffold tissue engineering [ 18 , 19 , 20 ]. Nanofibers have been mostly produced by electrospinning [ 21 , 22 ], in which polymeric solutions are formed into nano-sized continuous fibers by applying a strong electric field.…”

Section: Introductionmentioning

confidence: 99%

In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System

et al. 2021

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In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible.

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“…Cyclodextrins (CDs) are cyclic oligosaccharides consisting of 1,4-linked glucopyranoside units having either six, seven, or eight glucose units arranged in a cyclic structure, nominated as alpha-, beta-, and gamma-CDs, respectively. CDs are approved by Food and Drug Administration (FDA) and the supramolecular structure of CDs enables electrospinning in water without any extra polymer [31,32]. As complexation with CDs can be tailored to the physical and scientific characteristics of integrated guest compounds, CDs are used in a variety of areas of applications, including pharmaceuticals, food, cosmetics, home/personal care, and textiles [33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biocompatible and Environmentally Nanofibrous Mats Loaded with Moxifloxacin as a Model Drug for Biomedical Applications

et al. 2020

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Biopolymeric chitosan structure (Cs) is rationally investigated owing to its potentiality in pharmaceutical applications. The synthetic routes of biomimetic Cs-based blend electrospun nanofibers were studied. Herein, biocompatible crosslinked electrospun polyvinyl alcohol (PVA)/Cs-reduced gold nanoparticles (Cs(Rg))/β-CD (beta-cyclodextrin) in pure water were fabricated. To this end, supportive PVA as a carrier, Cs bio modifier, and gold reductant and β-CD as smoother, inclusion guest molecule, and capping agent exhibit efficient entrapment of moxifloxacin (Mox) and consequently accelerate release. Besides, PVA/Cs(Rg)/β-CD paves towards controlled drug encapsulation-release affinity, antimicrobial, and for wound dressing. Without losing the nanofiber structure, the webs prolonged stability for particle size and release content up to 96.4%. The synergistic effect of the nanoformulation PVA/Cs(Rg)/β-CD against pathogenic bacteria, fungus, and yeast, including Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger, posed clear zones up to 53 φmm. Furthermore, a certain combination of PVA/Cs (Rg)/β-CD showed a total antioxidant capacity of 311.10 ± 2.86 mg AAE/g sample. In vitro cytotoxicity assay of HePG2 and MCF-7 NF6 can eradicate 34.8 and 29.3 µg/mL against selected cells.

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Hydrocortisone/cyclodextrin complex electrospun nanofibers for a fast-dissolving oral drug delivery system

Abstract: Hydrocortisone/cyclodextrin complex nanofibrous webs were produced via electrospinning in order to develop a fast-dissolving oral drug delivery system.

Cited by 54 publications

References 69 publications

Electrospinning: A promising technique for drug delivery systems

Electrospinning: A promising technique for drug delivery systems

In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System

Synthesis of Biocompatible and Environmentally Nanofibrous Mats Loaded with Moxifloxacin as a Model Drug for Biomedical Applications

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