Hydrocortisone has a biphasic effect on rat gastric mucosal prostaglandin generation in vivo: Inhibition at low doses, stimulation at high doses

Avunduk, Canan; Eastwood, Gregory L.; Polakowski, Nancy

doi:10.1016/0952-3278(92)90091-v

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…Glucocorticoids have elsewhere also been indicated to have pro-inflammatory effects, in the central nervous system, 43 and in certain murine cells such as rat gastric mucosa, they have been shown to stimulate prostaglandin production. 44 Overall, we believe further investigation of the effects of TA and LPS on prostaglandin production in equine joints is warranted.…”

Section: Discussionmentioning

confidence: 97%

Treatment effects of intra‐articular triamcinolone acetonide in an equine model of recurrent joint inflammation

Kearney

Korthagen

Plomp

et al. 2020

Equine Veterinary Journal

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Background: Intra-articular triamcinolone acetonide is a widely used treatment for joint inflammation despite limited scientific evidence of its efficacy. Objectives:To investigate if intra-articular triamcinolone acetonide has sustained anti-inflammatory effects using an equine model of repeated joint inflammation. Study design:Randomised controlled experimental study.Method: For three consecutive cycles 2 weeks apart, inflammation was induced in both middle carpal joints of eight horses by injecting 0.25 ng lipopolysaccharide (LPS).After the first LPS injection only, treatment with 12 mg triamcinolone acetonide (TA) followed in one randomly assigned joint, while the contralateral joint was treated with sterile saline (control). Clinical parameters (composite welfare scores, joint effusion, joint circumference) were recorded and synovial fluid samples were analysed for various biomarkers (total protein, WBCC; PGE 2 ; CCL2; TNFα; MMP; GAGs; C2C; CPII) at fixed timepoints (post injection hours 0, 8, 24, 72 and 168). The effects of time and treatment on clinical and synovial fluid parameters and the presence of time-treatment interactions were tested using a linear mixed model for repeated measures with horse as a random effect, and time and treatment as fixed effects. Results:The TA treated joints showed significantly higher peak synovial GAG concentrations (Difference in means 283.1875 µg/mL, 95% CI 179.8, 386.6, P < 0.000), and PGE 2 levels (Difference in means 77.8025 pg/mL, 95% CI 21.2, 134.4, P < 0.007) after the first inflammation induction. Significantly lower TP levels were seen with TA treatment after the second induction

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Section: Discussionmentioning

confidence: 97%

Treatment effects of intra‐articular triamcinolone acetonide in an equine model of recurrent joint inflammation

Kearney

Korthagen

Plomp

et al. 2020

Equine Veterinary Journal

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“…In rats, circulating cortisol was not associated with induction of stress ulcer, but stress ulcers were associated with a decrease in prostaglandins 38. In another experimental study in rats, hydrocortisone had a biphasic effect on prostaglandin levels, with low doses inhibiting and high doses stimulating prostaglandin production 39. Furthermore, exogenous steroids have been shown to reduce gastric ulcer healing in experimentally induced gastric ulcer model in rats due to decreased cellular proliferation at the ulcer edge 40.…”

Section: Pathophysiologymentioning

confidence: 97%

<p>Equine glandular gastric disease: prevalence, impact and management strategies</p>

Banse¹,

Andrews²

2019

VMRR

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Equine glandular gastric disease (EGGD) is an increasingly recognized disease of the glandular mucosa of the equine stomach. Diagnosis is confirmed by gastric endoscopy and scored based upon one of several different endoscopic scoring systems. Prevalence appears to be variable, depending upon breed and discipline. Primary identified risk factors include exercise frequency, and stress; therefore, management strategies are focused on reducing exercise and stress. Limiting grain intake and increasing pasture turnout may also be helpful preventative measures. Pharmacologic treatment consists primarily of an approved omeprazole product with or without misoprostol or sucralfate. Further research into the pathophysiology of EGGD may allow for identification of other targeted treatments.

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“…The glucose-cortisol relationship was U-shaped, a mirror image of that observed with embryonic size and allantoic volume. Such a relationship has also been reported for dexamethasone and neonatal rat kidney function (Slotkin et al 1992), and for hydrocortisone sodium succinate effects on rat gastric mucosal prostaglandin synthesis (Avunduk et al 1992). Such curves are often associated with an abatement of adverse effects at increasingly low doses; for example, the effects of X-ray dose on cancer incidence (Calabrese & Baldwin, 1999).…”

Section: Figure 3 Effects Of Treatments On Glucocorticoid Receptor Mmentioning

confidence: 64%

Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development

Klemcke¹,

Vallet²,

Christenson³

2006

Experimental Physiology

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A study was conducted to evaluate the influence of maternal cortisol on early conceptus development in pigs (Sus scrofa). The corticosteroid synthesis inhibitor metyrapone was injected daily during days 14-19 of pregnancy, without (n = 6) and with commensurate administration of cortisol (n = 6). Blood samples were taken via an indwelling jugular catheter on days 14 and 18, and conceptuses were harvested during surgery on day 20. Compared with vehicle-injected control dams (n = 7) plasma cortisol and aldosterone concentrations were decreased (P < 0.01) by 52 and 29%, respectively, by metyrapone treatment. Cortisol administration reversed decreases in plasma cortisol by day 18. There were no treatment-associated effects on conceptus survival or size. Nor were there treatment-associated effects on allantoic fluid volume or content. Trophodermal glucocorticoid receptor (GR) mRNA expression decreased by 34% (P < 0.05) in metyrapone-treated pigs, and was not further influenced by concomitant administration of cortisol, thereby suggesting an influence of aldosterone on GR mRNA expression. Also, when all pigs were considered, there were treatment-independent second-order polynomial regressions (P < 0.05) between maternal plasma cortisol concentrations and embryonic weight, allantoic size and allantoic glucose concentrations, and between plasma aldosterone concentrations and trophodermal GR mRNA expression. Such biphasic corticosteroid concentration versus tissue parameter curves are noteworthy, but difficult to interpret validly. They may suggest that an appropriate corticosteroid environment is necessary for optimal porcine embryonic development during this stage of gestation, but cannot overshadow the absence of treatment effects on the porcine embryonic measures evaluated.

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Hydrocortisone has a biphasic effect on rat gastric mucosal prostaglandin generation in vivo: Inhibition at low doses, stimulation at high doses

Cited by 10 publications

References 24 publications

Treatment effects of intra‐articular triamcinolone acetonide in an equine model of recurrent joint inflammation

Treatment effects of intra‐articular triamcinolone acetonide in an equine model of recurrent joint inflammation

<p>Equine glandular gastric disease: prevalence, impact and management strategies</p>

Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development

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