Hydrogel based approaches for cardiac tissue engineering

Saludas, Laura; Pascual-Gil, Simón; Prósper, Felipe; Garbayo, Elisa; Blanco-Prieto, María J.

doi:10.1016/j.ijpharm.2016.10.061

Cited by 124 publications

(90 citation statements)

References 202 publications

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“…Hydrogels are valuable tools in tissue engineering and regenerative medicine due to their biocompatibility, tunable mechanics, and ability to deliver an array of cells and biomolecules . Hydrogels are defined as water‐swollen, insoluble networks of crosslinked polymers, exhibiting high‐water content, biomimetic elasticity, and tissue‐like diffusion properties .…”

Section: Introductionmentioning

confidence: 99%

A Biocompatible Therapeutic Catheter‐Deliverable Hydrogel for In Situ Tissue Engineering

Steele

Stapleton

Farry

et al. 2019

Adv Healthcare Materials

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Hydrogels have emerged as a diverse class of biomaterials offering a broad range of biomedical applications. Specifically, injectable hydrogels are advantageous for minimally invasive delivery of various therapeutics and have great potential to treat a number of diseases. However, most current injectable hydrogels are limited by difficult and time‐consuming fabrication techniques and are unable to be delivered through long, narrow catheters, preventing extensive clinical translation. Here, the development of an easily‐scaled, catheter‐injectable hydrogel utilizing a polymer–nanoparticle crosslinking mechanism is reported, which exhibits notable shear‐thinning and self‐healing behavior. Gelation of the hydrogel occurs immediately upon mixing the biochemically modified hyaluronic acid polymer with biodegradable nanoparticles and can be easily injected through a high‐gauge syringe due to the dynamic nature of the strong, yet reversible crosslinks. Furthermore, the ability to deliver this novel hydrogel through a long, narrow, physiologically‐relevant catheter affixed with a 28‐G needle is highlighted, with hydrogel mechanics unchanged after delivery. Due to the composition of the gel, it is demonstrated that therapeutics can be differentially released with distinct elution profiles, allowing precise control over drug delivery. Finally, the cell‐signaling and biocompatibility properties of this innovative hydrogel are demonstrated, revealing its wide range of therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

A Biocompatible Therapeutic Catheter‐Deliverable Hydrogel for In Situ Tissue Engineering

Steele

Stapleton

Farry

et al. 2019

Adv Healthcare Materials

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show abstract

“…The low availability of donors and the limited lifespan of implants makes it necessary to look for alternatives such as the injection of cardiac cells and stem cells. However, this faces restrictions related to immunogenicity, poor cellular retention, and biological activity (Saludas, Pascual‐Gil, Prosper, Garbayo, & Blanco‐Prieto, ). Today, MI is being addressed by advanced hydrogels (Table ).…”

Section: Hydrogels For Treatment Of Diabetes‐related Conditionsmentioning

confidence: 99%

Advanced hydrogels for treatment of diabetes

Reyes-Martínez

Ruíz-Pacheco²,

Flores-Valdéz

et al. 2019

J Tissue Eng Regen Med

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Diabetes mellitus is a chronic disease characterized by high levels of glucose in the blood, which leads to metabolic disorders with severe consequences. Today, there is no cure for diabetes. The current management for diabetes and derived medical conditions, such as hyperglycemia, cardiovascular diseases, or diabetic foot ulcer, includes life style changes and hypoglycemia‐based therapy, which do not fully restore euglycemia or the functionality of damaged tissues in patients. This encourages scientists to work outside their boundaries to develop routes that can potentially tackle such metabolic disorders. In this regard, acellular and cellular approaches have represented an alternative for diabetics, although such treatments still face shortcomings related to limited effectiveness and immunogenicity. The advent of biomaterials has brought significant improvements for such approaches, and three‐dimensional extracellular matrix analogs, such as hydrogels, have played a key role in this regard. Advanced hydrogels are being developed to monitor high blood glucose levels and release insulin, as well as serve as a therapeutic technology. Herein, the state of the art in advanced hydrogels for improving treatment of diabetes, from laboratory technology to commercial products approved by drug safety regulatory authorities, will be concisely summarized and discussed.

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“…Much work has been conducted seeking to in situ form hydrogels that are capable of regenerating different types of tissue. Among them, it is worth mentioning in situ generated hydrogels that were used for cardiac repair, aiming, for example, at minimizing left ventricle remodeling after myocardial infarcts …”

Section: Chemical Phenomenamentioning

confidence: 99%

In Situ Generated Medical Devices

Cohn

Sloutski

Elyashiv

et al. 2019

Adv Healthcare Materials

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Medical devices play a major role in all areas of modern medicine, largely contributing to the success of clinical procedures and to the health of patients worldwide. They span from simple commodity products such as gauzes and catheters, to highly advanced implants, e.g., heart valves and vascular grafts. In situ generated devices are an important family of devices that are formed at their site of clinical function that have distinct advantages. Among them, since they are formed within the body, they only require minimally invasive procedures, avoiding the pain and risks associated with open surgery. These devices also display enhanced conformability to local tissues and can reach sites that otherwise are inaccessible. This review aims at shedding light on the unique features of in situ generated devices and to underscore leading trends in the field, as they are reflected by key developments recently in the field over the last several years. Since the uniqueness of these devices stems from their in situ generation, the way they are formed is crucial. It is because of this fact that in this review, the medical devices are classified depending on whether their in situ generation entails chemical or physical phenomena.

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Hydrogel based approaches for cardiac tissue engineering

Cited by 124 publications

References 202 publications

A Biocompatible Therapeutic Catheter‐Deliverable Hydrogel for In Situ Tissue Engineering

A Biocompatible Therapeutic Catheter‐Deliverable Hydrogel for In Situ Tissue Engineering

Advanced hydrogels for treatment of diabetes

In Situ Generated Medical Devices

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