Hydrogel-Based Delivery Systems for Topical Antifungal Therapy: A Review

Abstract

Fungal skin infections are a significant global health concern, with a high prevalence, recurrence, and economic burden. Traditional antifungal therapies, such as creams and oral formulations, often suffer from limitations, including poor aqueous solubility, low bioavailability, and the emergence of drug resistance, which can compromise their therapeutic efficacy. In this context, hydrogel-based delivery systems have emerged as a promising approach to address these challenges. Hydrogels offer several advantages, including high drug loading capacity, controlled drug release, improved biocompatibility, and enhanced penetration through the skin barrier. This comprehensive review article provides an in-depth analysis of recent advancements in developing antifungal hydrogels. It explores the various preparation methods. The review also highlights the therapeutic applications of antifungal hydrogels, covering a wide range of fungal skin infections. Furthermore, the article examines the current trends and future perspectives in the field, including the incorporation of novel active pharmaceutical ingredients, the exploration of hybrid systems, and the development of stimuli-responsive hydrogels for enhanced targeting and responsiveness. By synthesizing the latest research and addressing the unmet needs in antifungal therapy, this review aims to provide valuable insights and guidance for researchers and clinicians working towards the development of more effective and patient-centric antifungal treatment approaches.