Hydrogel based injectable scaffolds for cardiac tissue regeneration

Radhakrishnan, Janani; Krishnan, Uma Maheswari; Sethuraman, Swaminathan

doi:10.1016/j.biotechadv.2013.12.010

Cited by 161 publications

(153 citation statements)

References 143 publications

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“…Its role in the body is both structurally and functionally, as being involved in complex mechanisms regulating of tissue growth and recovery [3,17,25]. Collagen is wildly used in medical applications due its biocompatibility, biodegradability, weak antigenicity and mostly because can be mixed with therapeutic proteins and drugs [3,17,18].…”

Section: Collagenmentioning

confidence: 99%

“…Collagen is wildly used in medical applications due its biocompatibility, biodegradability, weak antigenicity and mostly because can be mixed with therapeutic proteins and drugs [3,17,18]. This protein presents an environment conducive to cell viability, promoting cell attachment and proliferation [3].…”

Section: Collagenmentioning

confidence: 99%

“…The main disadvantage of this polymer refers to their week mechanical properties, but these properties can be improved by modifying the molecular structure and composition with various functionalization [3,7,[35][36][37].…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

“…It was reported that in USA, the myocardial infarction affects annually over 900,000 people and in the entire word approximately 50% of the people suffering myocardial infarction (MI) die within 5 years [2,3]. The main causes leading to congestive heart failure are represented by adverse remodeling of the left ventricle, loss of nonregenerative cardiomyocytes and myocardial infarction [3].…”

Section: Introductionmentioning

confidence: 99%

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Hydrogels for Cardiac Tissue Repair and Regeneration

Grigore¹

2017

J Cardiovasc Med Cardiol

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The main cause of death in the world continues to be cardiovascular disease, which affects annually over 900,000 people and in the entire word approximately 50% of the people suffering myocardial infarction (MI) die within 5 years. MI causes a number of cardiac pathologies like hypertension, blocked coronary arteries and valvular heart diseases resulting ischemic cardiac injury. In the last years, cardiac tissue engineering has made considerable progress, because this progress have been made towards developing injectable hydrogels for the purpose of cardiac repair and/or regeneration. This study aims to provide an updated survey of the major progress in the fl ied of injectable cardiac tissue engineering, including biomaterials (natural, synthetic or hybrid hydrogels), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the fi eld of hydrogels for cardiac tissue repair and/or regeneration for MI over the last years.

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Section: Collagenmentioning

confidence: 99%

Section: Collagenmentioning

confidence: 99%

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hydrogels for Cardiac Tissue Repair and Regeneration

Grigore¹

2017

J Cardiovasc Med Cardiol

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“…Moreover, it can be easily electrospun and can be used for long-term sustained delivery of pharmaceutical agents in the field of drug delivery and tissue engineering [9][10][11][12][13]. On the other hand, polyethylene glycol (PEG) is a water soluble polyether with a wide range of molecular weights that has been found to be biocompatible and has been used in hydrogels, for surface modification of other polymers to obtain co-polymers, control of protein adsorption and as an adhesion molecule [14]. Therefore, the use of both polymers as a single blend could lead to products that exhibit a combination of properties, suitable for applications in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Pcl/Peg Electrospun Fibers as Drug Carriers for the Controlled Delivery of Dipyridamole

Repanas¹,

Wf²,

O³

et al. 2015

J In Silico In Vitro Pharmacol

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Electrospinning is a versatile and diverse technology for the production of nano-and microfibers that can be used as a drug delivery system (DDS). The aim of this study was to create fibrous scaffolds from a mixture of polycaprolactone (PCL) and polyethylene glycol (PEG) and to evaluate the suitability of the fibers as DDS. Dipyridamole (DPA), an anti-thrombotic and anti-proliferative pharmaceutical agent, was used as a model drug. Two types of PEG with different chain length were used. The structural, mechanical and physicochemical characteristics of the fibers with and without DPA, were determined, and the release kinetics of DPA were studied. The obtained fibers loaded with DPA and with the higher molecular weight PEG were smooth and had an average diameter of 586.75 ± 204.79 nm and an average Young's modulus of 57.14 ± 4.35 MPa, whereas the tensile strain at break was 0.61 ±0.05 mm/mm and the ultimate tensile strength (UTS) was 16.79 ± 3.08 MPa. The cumulative release of DPA revealed two stages: an initial burst phenomenon followed by slower Fickian diffusion (release exponent n = 0.432).

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