Hydrogel-Based Microneedle as a Drug Delivery System

Filho, David; Guerrero, Marcelo; Pariguana, Manuel; Marican, Adolfo; Durán-Lara, Esteban F.

doi:10.3390/pharmaceutics15102444

Cited by 17 publications

(1 citation statement)

References 116 publications

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“…MN technology provides several benefits compared to traditional patches and syringe injections, which include a painless experience [ 6 ], ease of use [ 7 ], a reduced chance of infection [ 8 ], and capacity for self-administration [ 9 ]. Moreover, it also enables the delivery of a wide range of therapeutics into the skin layers with minimally invasive pain [ 10 ]. MNs are generally categorized into solid MNs, coated MNs, hollow MNs, dissolvable MNs, and hydrogel MNs [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

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Microneedle (MN) technology is an optimal choice for the delivery of drugs via the transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine delivery, and disease diagnostics. The MN is a biomedical device that offers many advantages including but not limited to a painless experience, being time-effective, and real-time sensing. This research implements additive manufacturing (AM) technology to fabricate MN arrays for advanced therapeutic applications. Stereolithography (SLA) was used to fabricate six MN designs with three aspect ratios. The MN array included conical-shaped 100 needles (10 × 10 needle) in each array. The microneedles were characterized using optical and scanning electron microscopy to evaluate the dimensional accuracy. Further, mechanical and insertion tests were performed to analyze the mechanical strength and skin penetration capabilities of the polymeric MN. MNs with higher aspect ratios had higher deformation characteristics suitable for penetration to deeper levels beyond the stratum corneum. MNs with both 0.3 mm and 0.4 mm base diameters displayed consistent force–displacement behavior during a skin-equivalent penetration test. This research establishes guidelines for fabricating polymeric MN for high-accuracy and low-cost 3D printing.

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Section: Introductionmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

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Advanced functional polymer materials for biomedical applications

Elsayed,

Teow

2024

J of Applied Polymer Sci

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Polymer structures are essential in biomedical applications due to their biocompatibility, biodegradability, and ability to form intricate structures on micro‐ to nanometer scales. This review, emphasizing electrospinning and phase inversion techniques, examines the fabrication strategies and chemical design of polymer structures for biomedical use. Electrospinning, particularly needleless electrospinning, produces nanofibres with high porosity and flexibility and is widely applied in tissue engineering and drug delivery. Phase inversion, including thermal, nonsolvent‐, vapor‐ and evaporation‐induced phase separation, allows precise control over polymer properties but faces challenges in terms of cooling rates and solvent characteristics. Chemical design through doping, functionalization, cross‐linking and copolymerization enhances the biocompatibility, biodegradability and mechanical properties of polymers, facilitating advanced applications in drug delivery, tissue scaffolding and biosensors. Advanced functional polymers are revolutionizing biomedical fields, offering innovative solutions for therapeutic medicine delivery, disease detection, diagnostics, and regenerative medicine. Despite remarkable progress, challenges, such as scalability, cost‐effectiveness, and environmental impact, persist. This review underscores the transformative potential of advanced polymer materials in medical treatments and advocates for continuous research and interdisciplinary collaboration to overcome existing challenges and fully exploit the capabilities of these materials in improving patient care and medical outcomes. Future perspectives highlight enhancing precision control mechanisms, integrating phase inversion with other techniques and developing large‐scale production methods to advance the field further.

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The Synergistic Potential of Hydrogel Microneedles and Nanomaterials: Breaking Barriers in Transdermal Therapy

Golshirazi,

Mohammadzadeh,

Labbaf

2024

Macromolecular Bioscience

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The stratum corneum, which acts as a strong barrier against external agents, presents a significant challenge to transdermal drug delivery. In this regard, microneedle (MN) patches, designed as modern systems for drug delivery via permeation through the skin with the ability to pass through the stratum corneum, are known to be convenient, painless, and effective. In fact, MN have shown significant breakthroughs in transdermal drug delivery, and among the various types, hydrogel MN (HMNs) have demonstrated desirable inherent properties. Despite advancements, issues such as limited loading capacity, uncontrolled drug release rates, and non‐uniform therapeutic approaches persist. Conversely, nanomaterials (NMs) have shown significant promise in medical applications, however, their efficacy and applicability are constrained by challenges including poor stability, low bioavailability, limited payload capacity, and rapid clearance by the immune system. Incorporation of NMs within HMNs offers new prospects to address the challenges associated with HMNs and NMs. This combination can provide a promising field of research for improved and effective delivery of therapeutic agents and mitigate certain adverse effects, addressing current clinical concerns. The current review highlights the use of NMs in HMNs for various therapeutic and diagnostic applications.

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Hydrogel-Based Microneedle as a Drug Delivery System

Cited by 17 publications

References 116 publications

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Advanced functional polymer materials for biomedical applications

The Synergistic Potential of Hydrogel Microneedles and Nanomaterials: Breaking Barriers in Transdermal Therapy

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