Hydrogel-Based Skin Regeneration

Abstract

The skin is subject to damage from the surrounding environment. The repair of skin wounds can be very challenging due to several factors such as severe injuries, concomitant infections, or comorbidities such as diabetes. Different drugs and wound dressings have been used to treat skin wounds. Tissue engineering, a novel therapeutic approach, revolutionized the treatment and regeneration of challenging tissue damage. This field includes the use of synthetic and natural biomaterials that support the growth of tissues or organs outside the body. Accordingly, the demand for polymer-based therapeutic strategies for skin tissue defects is significantly increasing. Among the various 3D scaffolds used in tissue engineering, hydrogel scaffolds have gained special significance due to their unique properties such as natural mimicry of the extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, and biocompatibility properties. First, this article delineates the process of wound healing and conventional methods of treating wounds. It then presents an examination of the structure and manufacturing methods of hydrogels, followed by an analysis of their crucial characteristics in healing skin wounds and the most recent advancements in using hydrogel dressings for this purpose. Finally, it discusses the potential future advancements in hydrogel materials within the realm of wound healing.

Advancements and Applications of Electrospray Methods in Skin Tissue Regeneration

“…Hydrogels are particularly effective due to their high-water content and soft tissue-like consistency, which makes them ideal for interacting with the natural skin environment. They promote cell adhesion, proliferation, and migration-all critical for tissue regeneration [19]. Moreover, it has been suggested that biomimetic methods capable of mirroring the structure of the extracellular matrix improve the healing process by offering signals that guide cell behavior and tissue growth [20].…”

Albumin-Based Hydrogel Films Covalently Cross-Linked with Oxidized Gellan with Encapsulated Curcumin for Biomedical Applications

“…Recent studies show promising results for skin tissue regeneration in diabetic and burn wound patients. Polymer-based therapeutic approaches for skin defects using scaffolds made of polymeric materials have become popular in recent years, promoting tissue regeneration [ 1 ]. When skin is injured, proper wound care plays a crucial role in avoiding bacterial infection and accelerating wound healing.…”

“…Moreover, hydrogels can be engineered to have therapeutic agent-delivery capabilities, responsive properties, and smart-monitoring abilities, and can serve as delivery vehicles for therapeutic agents such as drugs, cells, and nanoparticles. Stimuli-responsive hydrogels can be used as smart, responsive materials to achieve the on-demand controlled release of loaded active substances [ 1 , 8 ]. The structure and composition of hydrogels closely resemble that of the natural extracellular matrix (ECM).…”

“…The amount of polyphenol within the complex was determined based on the calibration curve of curcumin in ethanol. The degree of complexation (CD, %) was determined as follows: CD% = Amount of curcumin in the inclusion complex/total amount of curcumin × 100 (1) The calibration curve of curcumin in ethanol has the equation y = 0.0167x (R 2 = 0.999). Figure 1 illustrates the process of obtaining β-cyclodextrin complexes with curcumin.…”

Cerium Dioxide–Dextran Nanocomposites in the Development of a Medical Product for Wound Healing: Physical, Chemical and Biomedical Characteristics

“…Regeneration in skin injuries is the second most important but the most frequently addressed problem. Acute skin damage in everyday life is a routine situation, but chronic ulcers in patients with diabetes mellitus, tissue arterial ischemia, varicose veins, and postthrombotic syndrome are a heavy burden on family and state budgets [ 15 , 16 , 17 , 18 ]. Great hopes were pinned on mesenchymal stem cells.…”