Hydrogel-based zinc ion sensor on optical fiber with high resolution and application to neural cells

Tsai, Ming-Tzu; Cheng, Henrich; Ho, Hsin Hsien; Lin, Peng Wei; Liou, Dann Ying; Fang, Teng; Li, Chao Wei; Kwan, Karmeng; Chen, Yen‐Chi; Huang, Chih‐Feng; Horng, Sheng Fu; Hung, Chen‐Hsiung; Zan, Hsiao Wen; Meng, Hsin Fei

doi:10.1016/j.bios.2020.112230

Cited by 10 publications

(5 citation statements)

References 16 publications

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“…A hydrogel material was mixed with probe molecules TPN-Cl 2 (meso-2,6-dichlorophenyltripyrrinone) for Zn 2+ detection. 352 The fluorescence of the probe molecule increased with the concentration of Zn 2+ ions released by artificial stress of rodent neural cells. To prevent probe molecule degradation, the optical diffuser in the sensor converted the high peak intensity at 405 nm near the fiber end into a moderate intensity at 622 nm.…”

Section: Sensor Applicationsmentioning

confidence: 97%

“…The Zn 2+ ion activates approximately 300 enzymes and has roles in males' reproduction and nervous system. 352 For instance, researchers have reported the release of the Zn 2+ ion in higher concentration during acute brain injuries such as seizure, trauma, and ischemia. 353,354 Hence, the Zn 2+ ion is an excellent biochemical indicator for monitoring neural injury.…”

Section: Sensor Applicationsmentioning

confidence: 99%

“…This variation in intensity was monitored by the optical sensor. 352 A tip-shaped solid-state sensor allowed the real-time detection of Zn 2+ ions under aqueous conditions (Fig. 12f).…”

Section: Sensor Applicationsmentioning

confidence: 99%

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Hydrogel-integrated optical fiber sensors and their applications: a comprehensive review

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Section: Sensor Applicationsmentioning

confidence: 97%

Section: Sensor Applicationsmentioning

confidence: 99%

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Hydrogel-integrated optical fiber sensors and their applications: a comprehensive review

et al. 2023

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“…To meet the requirements of biomimetic skin, the hydrogel matrix had been designed with different functional polymers 9 . By assembling, these designed hydrogels are well responsive to different stimulus, even tiny changes in the external environment, such as temperature, 10 pH, 11 ion, 12 electricity, 7a,13 pressure, 14 and so on. All these characteristics support the intelligent hydrogel as a potential material in biomimetic sensor.…”

Section: Introductionmentioning

confidence: 99%

The composite hydrogel with “2D flexible crosslinking point” of reduced graphene oxide for strain sensor

Xiang

Zhu

et al. 2021

J of Applied Polymer Sci

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Intelligent hydrogels with excellent flexibility, biocompatibility, and stimulus responsivity can mimic the functions of the skin to detect human motions. However, the low mechanical strength limits its application in the field of biomimetic materials. In this work, polyacrylamide‐reduced graphene oxide (PAM‐rGO) composite hydrogels were prepared by the combination of PAM and partially rGO, and their biomimetic strain sensors were studied. The rGO played the role of “2D flexible crosslinking point” in the composite hydrogel. Through the H‐bonds between rGO and hydrogels, the toughness and strength of the composite hydrogel were enhanced. The maximum strain of the hydrogel changed from 751% to 1097%, and the maximum stress changed from 0.065 to 0.20 MPa. On the other hand, the interaction between the PAM backbone and the rGO provided a credible resistance response to the stimulation of strain. The better linear relationship between resistance and length was built, with R2 of 0.992. Furthermore, the composite hydrogels were assembled into wearable devices to monitor human‐motion, including fingers bending, elbows bending and walking. The experimental results showed that the PAM‐rGO composite hydrogel had great potential in the field of bionic skin.

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“…In such cases, invasive monitoring can provide the real-time information of the brain during or after surgery to help obtain the best possible functional neurological outcome . So far, there are few reports on the chemical probes that focus on miniaturizing the probe’s cross-sectional area for potential application in such surgery with small incision. − A zinc ion sensor has also been proposed in our previous work, for which zinc ion concentration is related with brain injury. , However, the overall sensor size and their planar geometry are not perfect for an invasive device.…”

Section: Introductionmentioning

confidence: 99%

A Cylindrical Ion Sensor Tip with a Diameter of 1.5 mm for Potentially Invasive Medical Application

Nguyen

Chen

et al. 2020

ACS Omega

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A fine cylindrical chemical sensor tip is developed with optical fiber in the core, surrounded by a transparent cylinder of photopolymer Norland Optical Adhesive 61 (NOA 61), and covered by a polymer hydrogel mixed with sensing molecules. The overall diameter is as small as 1.5 mm. pH response is demonstrated using two approaches of sensing materials: (i) absorbing probe Phenol Red mixed with Rhodamine 6G fluorescent dye and (ii) 8-hydroxypyrene-1,3,6-trisulfonic acid fluorescent probe. Both the optical excitation and fluorescence signal collection are through the optical fibers. A time resolution of 10 s is achieved for pH variations. Good linearity is observed in the physiological range from pH 7.0 to pH 8.6 with reversible and reproducible outcomes. For in vitro urea measurement, the sensor tip can distinguish 1, 3, and 5 mM urea solution, which is a crucial range in saliva urea concentration. The miniaturized tip with such simple cylindrical symmetry is designed to detect vital signs during minimally invasive surgeries and can be potentially accompanied with endoscopes to enter human bodies.

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Hydrogel-based zinc ion sensor on optical fiber with high resolution and application to neural cells

Cited by 10 publications

References 16 publications

Hydrogel-integrated optical fiber sensors and their applications: a comprehensive review

Hydrogel-integrated optical fiber sensors and their applications: a comprehensive review

The composite hydrogel with “2D flexible crosslinking point” of reduced graphene oxide for strain sensor

A Cylindrical Ion Sensor Tip with a Diameter of 1.5 mm for Potentially Invasive Medical Application

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