Hydrogel delivery systems for vaginal and oral applications

Knuth, Kim; Amiji, Mansoor M.; Robinson, Joseph R.

doi:10.1016/0169-409x(93)90030-8

Cited by 78 publications

(36 citation statements)

References 35 publications

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“…The first bioadhesive systems for vaginal drug delivery were in the form of tablets for the delivery of bleomycin, an anti-caner agent (70)(71)(72)(73)(74)(75). Attempts have also been made to delivery of microbicides using bioadhesive microparticulate vaginal systems (73)(74)(75)(76)(77)(78)99). These systems may be a multi-phase liquid or a semi-solid, but have been designed so as not to seep from the vagina like pessary formulations.…”

Section: Bioadhesive Intravaginal Systemsmentioning

confidence: 99%

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

et al. 2008

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Abstract. The objective of this review is to describe the current status of several intravaginal anti-HIV microbicidal delivery systems these delivery systems and microbicidal compounds in the context of their stage within clinical trials and their potential cervicovaginal defence successes. The global Human Immuno-Deficiency Virus (HIV) pandemic continues to spread at a rate of more than 15,000 new infections daily and sexually transmitted infections (STIs) can predispose people to acquiring HIV infection. Male-to-female transmission is eight times more likely to occur than female-to-male transmission due to the anatomical structure of the vagina as well as socio-economic factors and the disempowerment of women that renders them unable to refuse unsafe sexual practices in some communities. The increased incidence of HIV in women has identified the urgent need for efficacious and safe intravaginal delivery of anti-HIV agents that can be used and controlled by women. To meet this challenge, several intravaginal anti-HIV microbicidal delivery systems are in the process of been developed. The outcomes of three main categories are discussed in this review: namely, dual-function polymeric systems, non-polymeric systems and nanotechnology-based systems. These delivery systems include formulations that modify the genital environment (e.g. polyacrylic acid gels and lactobacillus gels), surfactants (e.g. sodium lauryl sulfate), polyanionic therapeutic polymers (e.g. carageenan and carbomer/lactic acid gels), proteins (e.g. cyanovirin-N, monoclonal antibodies and thromspondin-1 peptides), protease inhibitors and other molecules (e.g. dendrimer based-gels and the molecular condom). Intravaginal microbicide delivery systems are providing a new option for preventing the transmission of STIs and HIV.

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Section: Bioadhesive Intravaginal Systemsmentioning

confidence: 99%

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

et al. 2008

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“…Gel has an advantage in simple usage in oral mucosa without pain. 13 CMC gel are the chosen gel, because of it's stability on storage, good tolerance of water miscible solvents and good adhesive strength.…”

Section: Discussionmentioning

confidence: 99%

“…It could be applied on oral mucosa without pain, 12 and in sequence, so that the effect are expected to be better. 13 Carboxylmethylcellulose (CMC) are the chosen gel. [13][14] CMC is one of cellulose derivative, a natural structural polymer found in plants.…”

Section: Introductionmentioning

confidence: 99%

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Penetration effect of prostaglandin E2 gel on oral mucosa of rats

Arifin

Widayati

Purwaningsih

et al. 2012

Dent. J. (Majalah Kedokteran Gigi)

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“…Thermosensitive hydrogel, which is polymer aqueous solution at room temperature and become hydrogel at physiological temperature, provides a method for convenient administration [16,17]. Therefore, the drug-loaded thermosensitive hydrogel solution has the ability to spread along the vaginal canal after injection and coat the vaginal epithelium by hydrogel formation [18]. Furthermore, the formed hydrogel served as a drug reservoir, and the released drug would be absorbed by epithelia or directly penetrated into virus to prohibit virus propagation [2,19].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive hydrogel of hydrophobically-modified methylcellulose for intravaginal drug delivery

Deng

et al. 2012

J Mater Sci: Mater Med

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Hydrogels with the advantages of prolonging drug release and administration convenience are necessary for intravaginal drug delivery to prevent sexual transmission of human immunodeficiency virus and other vaginal infections. In this study, the thermosensitive hydrogel of methylcellulose modified by stearic acid (MCS) were evaluated in the presence of NaCl and phosphates, which exhibited sol-to-gel transition performance at body temperature or even lower. The in vitro cytotoxicity and in vivo mucosal irritation were investigated and the results showed that MCS hydrogel possessed good biocompatibility similar with hydroxyethyl cellulose (HEC) gel. Significantly, the release studies revealed that MCS hydrogel could control tenofovir sustained release for 10 h without burst release, longer than that from HEC gel or poloxamer 407 hydrogel. Therefore, MCS thermosensitive hydrogel would be a promising carrier for intravaginal delivery of antiviral drugs for long time controlled release.

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Hydrogel delivery systems for vaginal and oral applications

Cited by 78 publications

References 35 publications

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

Penetration effect of prostaglandin E2 gel on oral mucosa of rats

Thermosensitive hydrogel of hydrophobically-modified methylcellulose for intravaginal drug delivery

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