Hydrogel for topical drug delivery based on Mimosa pudica seed mucilage: Development and characterization

Deore, Ujwaldip V.; Mahajan, Hitendra S.

doi:10.1016/j.scp.2022.100701

Cited by 5 publications

(2 citation statements)

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“…The β‐1,4‐linked xylose with glucose attached to the main chain at the β‐1,3 positions having a 3‐O‐methyl‐d‐glucose moiety has been quantified in the MP whole plant which has wide pharmaceutical applications as a binder [19] . Deore and Mahajan identified the polysaccharides (having 3‐O‐methyl‐d‐glucose moiety) from seeds of Mimosa pudica as a hydro‐gelling agent having pharmaceutical importance as a gelling agent [20] . Here, the GC/MS/MS study of the MP leaf enabled us to identify and report the phytochemicals having nutritional and pharmaceutical value.…”

Section: Resultsmentioning

confidence: 95%

“…[19] Deore and Mahajan identified the polysaccharides (having 3-O-methyl-d-glucose moiety) from seeds of Mimosa pudica as a hydro-gelling agent having pharmaceutical importance as a gelling agent. [20] Here, the GC/ MS/MS study of the MP leaf enabled us to identify and report the phytochemicals having nutritional and pharmaceutical value.…”

Section: Gc/ms Analysismentioning

confidence: 99%

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Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under‐Utilized Part

Gandhi,

Prasad,

Kumar

et al. 2023

Chemistry & Biodiversity

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Mimosa pudica L. (MP) is well‐known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES‐based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μg/g, respectively. Using GC/MS/MS analysis, fatty acid like oleic acid were identified. In ICP‐OES analysis, a significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The observed TPC and TFC for MP leaf extracts was 44.327 (±1.041) mg GAE/ g of wt. and 214.217 (±4.372) mg QCE/ g of wt., respectively. The DPPH assay depicted a strong antioxidant activity of MP leaf extracts with IC50 values of 0.796 (±0.081) mg/mL and a TEAC value of 0.0356 (±0.0003). A significant antacid activity (666 mg MP+400 mg CaCO3 >400 mg CaCO3 ≫666 mg Gelusil) of MP leaves was noticed. The methanolic extract of MP leaves demonstrated anti‐microbial activity against Staphylococcus aureus (15±2mm), Pseudomonas aeruginosa (12±2mm) and Escherichia coli (10±2mm). In silico studies confirmed the in vitro results obtained for antioxidant, antiacid, and anti‐microbial activities. In addition, in silico studies revealed the anti‐cancerous and anti‐inflammatory potential of the MP leaves. In summary, this study demonstrated the medicinal significance of MP leaves and the conversion of agro‐waste or the under‐utilized part of MP into pharmaceutical potent materials. Consequently, the present study highlighted that MP leaves alone have medicinal importance with good nutritional utility and possess large promise in the pharma industry along with improving bio‐valorization and the environment.

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Section: Resultsmentioning

confidence: 95%

Section: Gc/ms Analysismentioning

confidence: 99%