Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Ding, Yan-Wen; Li, Yang; Zhang, Zhi-Wei; Dao, Jin-Wei; Wei, Dai-Xu

doi:10.1016/j.bioactmat.2024.04.020

Cited by 8 publications

(2 citation statements)

References 94 publications

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“…Existing studies have shown that topical application of TES can mimic the pathological characteristics of AGA ( Zhang et al, 2016 ; Lin et al, 2019 ; Yuan et al, 2021 ; Ding et al, 2024 ). Compared to intraperitoneal and subcutaneous injection methods, topical application of TES reduces stress and pain in mice while creating a localized high concentration of hormone environment on the dorsal skin.…”

Section: Methodsmentioning

confidence: 99%

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Wang,

He,

Liu

et al. 2024

Front. Pharmacol.

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Background: Angrogenetic alopecia (AGA) is one of the most prevalent hair loss disorders worldwide. The hair follicle stem cell (HFSC) is closely related to the formation of hair follicle (HF) structure and HF self-renewal. The activation of HFSC in AGA is critical for hair growth. Pilose antler has been reported to have hair growth-promoting activity, but the mechanism of action on AGA and HFSC has not been reported.Methods: We previously extracted an active component from the pilose antler known as PAEs. In this study, we conducted experiments using AGA mice and HFSC. The effects of PAEs on hair growth in AGA mice were firstly detected, and then the mechanisms of PAEs for AGA were predicted by integrating network pharmacology and de novo transcriptomics data of pilose antler. Finally, biological experiments were used to validate the molecular mechanism of PAEs in treating AGA both in vivo and in vitro.Results: It was found that PAEs promoted hair regrowth by accelerating the activation of anagen, delaying the anagen-catagen transition. It also alleviated the morphological changes, such as hair shortening, thinning, miniaturization, and HF number reduction, and regulated the hair regeneration process of four subtypes of hair. We further found that PAEs could promote the proliferation of HFSC, outer root sheath (ORS) cells, and hair bulb cells in AGA mice. We then integrated network pharmacology and pilose antler transcriptomics data to predict that the mechanism of PAEs treatment in AGA mice is closely related to the PI3K-AKT/Wnt-β-Catenin pathways. Subsequently, it was also verified that PAEs could activate both pathways in the skin of AGA mice. In addition, we found that PAEs perhaps increased the number of blood vessels around dermal papilla (DP) in experiments in vivo. Meanwhile, the PAEs stimulated the HFSC proliferation in vitro and activated the AKT and Wnt pathways. However, the proliferative activity of HFSC was inhibited after blocking the Wnt pathway and AKT activity.Conclusion: This study suggests that the hair growth-promoting effect of PAEs in AGA mice may be closely related to the stimulation of the AKT and Wnt pathways, which in turn activates the proliferation of HFSC.

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Section: Methodsmentioning

confidence: 99%

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Wang,

He,

Liu

et al. 2024

Front. Pharmacol.

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“…In AGA model mice, V-R-MNs outperformed the clinical drug minoxidil, showing rapid anagen phase onset, improved hair quality, and greater coverage. This presents a safer and more effective strategy for AGA treatment, with potential applications for other related diseases [ 74 ].…”

Section: Miscellaneous Applicationsmentioning

confidence: 99%

Swellable Microneedles in Drug Delivery and Diagnostics

Omidian,

Dey Chowdhury

2024

Pharmaceuticals

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This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs in medical treatment and monitoring. Innovations in hydrogel-integrated MN arrays facilitate controlled drug release, thereby expanding treatment options for chronic diseases and conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, and manufacturing processes, as well as achievements in advanced manufacturing, biocompatibility, and versatile applications. Nonetheless, limitations in physiological responsiveness and long-term stability remain, necessitating further research in material innovation and integration with digital technologies. Future directions focus on expanding biomedical applications, material advancements, and regulatory considerations for widespread clinical adoption.

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Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair

Li,

Zhou,

Zhou

et al. 2024

Journal of Polymer Science

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In recent years, the prevalence of bone diseases is showing an increasing trend, which is mainly attributed to the aging of the global population. However, bone repair and regeneration are still an unsolved problem in the treatment of bone diseases, which include a series of biological events. Photocrosslinked natural hydrogel‐based microspheres (PNHMs) are spherical particles composed of photocrosslinked natural hydrogel components. Due to their morphology, injectability, and biocompatibility, PNHMs are widely used in tissue regeneration, particularly for bone defects. In this article, we review the available photocrosslinked natural materials for PNHMs, and then introduce their preparation methods. After that, we summarize the important advanced functionalities of PNHMs. For example, PNHMs can be loaded with different active ingredients to exert anti‐inflammatory, antibacterial, and antioxidant effects, while also realizing lubrication due to their specific shape and size distribution. In addition, the function of capturing ions can be realized via coordination. When applied in bone tissue engineering, PNHMs can promote angiogenesis and osteogenesis, with great potential in the treatment of bone diseases. Finally, the challenges and prospects of PNHMs for bone repair are discussed.

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Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Cited by 8 publications

References 94 publications

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Swellable Microneedles in Drug Delivery and Diagnostics

Advances in photocrosslinked natural hydrogel‐based microspheres for bone repair

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