Hydrogel Nanocomposite Systems

Ameliorating quercetin constraints in cancer therapy with pH-responsive agarose-polyvinylpyrrolidone -hydroxyapatite nanocomposite encapsulated in double nanoemulsion

“…Hydroxyapatite (1% w/v) was added to the AG-PVP hydrogel in this step. The addition of HAp to the prepared hydrogel of AG-PVP results in physical entanglement and formation of non-covalent bonds between polymers functional groups and HAp as well as QC added in the next step [25]. These J o u r n a l P r e -p r o o f interactions improve quercetin loading as a hydrophobic drug.…”

“…The addition of nanoparticles to hydrogels addresses the mentioned defects and paves the way for a wider application of hydrogels for drug delivery [24]. Reduced particle size, high surface area, controlled shape, and ability to incorporate hydrophobic molecules along with magnetic, thermal, and electrical properties that can be employed for responsive release of encapsulated drugs are among reasons that render hydrogel nanocomposites a promising candidate for stimuliresponsive targeted drug delivery [25]. In this direction, hydroxyapatite (HAp), a calcium phosphate derived mineral with morphology and composition resembling human hard tissues, well known for its high biocompatibility and drug-loading efficiency without immunogenic response, is a desirable nanoparticle for inclusion in hydrogels to provide the mentioned features to hydrogels.…”

A novel pH‐responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan‐based nanocarrier: Emphasis on the concurrent improvement of loading, sustained release, and apoptosis induction

“…These interactions result in the enhancement of curcumin loading in the nanocomposite. 32,38 3.2 | Curcumin loading in the fabricated hydrogel Firstly, curcumin was added to ethanol 96% v/v to dissolve it since it is a hydrophobic compound. Then, the dissolved curcumin was incorporated into the CS-Aga-MMT nanocomposite.…”

“…30,31 Nanoparticles' unique properties, including high surface area, controlled shape, reduced particle size, and the potential to be loaded with hydrophobic molecules, render their incorporation into hydrogels an apt solution to extend the capacity of hydrogels for the delivery of a broader range of therapeutics, including hydrophobic anti-cancer medicines. 32,33 In this vein, montmorillonite (MMT), a common clay mineral, which exhibits biocompatibility, biodegradability, and good mechanical properties, 34 was incorporated into the prepared CS-Aga hydrogel. As stated for nanoparticles, MMT incorporation as a biocompatible compound in the CS-Aga hydrogel can enhance the loading capacity of hydrogel, homogeneity of the hydrogel, and burst release control.…”

“…To address these shortcomings, nanoparticles are incorporated into hydrogels to prepare nanocomposite hydrogels 30,31 . Nanoparticles' unique properties, including high surface area, controlled shape, reduced particle size, and the potential to be loaded with hydrophobic molecules, render their incorporation into hydrogels an apt solution to extend the capacity of hydrogels for the delivery of a broader range of therapeutics, including hydrophobic anti‐cancer medicines 32,33 . In this vein, montmorillonite (MMT), a common clay mineral, which exhibits biocompatibility, biodegradability, and good mechanical properties, 34 was incorporated into the prepared CS‐Aga hydrogel.…”