Hydrogel sealant to prevent recurrent epithelial ingrowth in the setting of a LASIK flap buttonhole

Hirabayashi, Kristin E.; Manche, Edward E.

doi:10.1016/j.ajoc.2019.100518

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…In parallel, Ocu-Seal ® , a dendrimer-based synthetic ocular adhesive, was approved in Europe. [153] Since then, multiple studies have demonstrated the efficacity of ReSure ® in wound repair and corneal epithelialization, such as in post LASIK surgery for buttonhole formation recurrence prevention [154] and pars plana vitrectomy wound closure. [155] However, major challenges exist with the use of ReSure ® .…”

Section: Hydrogel-based Ocular Adhesives For Wound Repairmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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Section: Hydrogel-based Ocular Adhesives For Wound Repairmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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“…Presumably, the adhesive seals the flap and any fistula, thus preventing entry of epithelial cells underneath the LASIK flap. 33 , 34 Like in LASIK surgery, hydrogel sealant was used successively to treat recalcitrant epithelial ingrowth after small incision lenticule extraction (SMILE) procedure, which had previously recurred despite two flap lifts with epithelial debridement and flap edge re-suturing. 35 The use of hydrogel sealant to seal refractive surgery flaps has been suggested in cases with diabetes which have a propensity to develop epithelial ingrowth.…”

Section: Introductionmentioning

confidence: 99%

Tissue Adhesives for the Management of Corneal Perforations and Challenging Corneal Conditions

Sharma¹,

Sharma²,

Basu³

et al. 2023

OPTH

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Corneal perforations are ophthalmological emergencies which can have serious and detrimental consequences, if not managed timely and appropriately. These are a significant cause of ocular morbidity and can result in decreased vision, blindness, and even loss of the eye. Corneal perforations can be managed using a range of treatment approaches, including temporary solutions such as the application of corneal glue and bandage contact lens, as well as definitive treatment such as corneal transplantation. Tissue glues/adhesives were developed as substitutes for sutures in ophthalmic surgery. Unlike sutures, these glues are associated with shorter overall surgical times and reduced inflammation, thus improving postoperative comfort without compromising wound strength. The available tissue adhesives can be broadly classified into two types: synthetic (eg, cyanoacrylate derivatives) and biological (eg, fibrin glue). Cyanoacrylate glue is chiefly used as a corneal patch to manage acute corneal perforations and improve visual outcomes. Fibrin glue can be used instead of cyanoacrylate glue in many conditions with the benefits of reduced conjunctival and corneal inflammation and reaction. Apart from this, each type of adhesive is distinct in terms of its benefits as well as limitations and is accordingly used for different indications. The present review focuses on the two main types of tissue adhesives, their applications in the management of corneal perforations, the associated complications, safety and efficacy data related to their use available in the literature and the need for newer adhesives in this field.

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Epithelial implantation treatment after small-incision lenticule extraction

Piccinini

Vida

Piccinini

et al. 2020

J Cataract Refract Surg

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Two cases of epithelial implantation after small-incision lenticule extraction (SMILE) treated by Nd:YAG laser and interface sweeping are described. A 40-year-old woman and 33-year-old man underwent SMILE and subsequently were noted to have epithelial cells implanted into the surgical interface. One case was treated using Nd:YAG laser. The laser was focused to the level of the interface with an energy level of 0.3 mJ. The treatment covered the entire area of epithelial implantation. The second case was treated by opening the original SMILE incision and sweeping the residual epithelial cells from the interface followed by a washout. Both the Nd:YAG laser and interface sweeping proved to be effective in reducing or eliminating the epithelial cells from the SMILE interface. Further studies are needed to report on overall safety and efficacy of these 2 techniques.

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Hydrogel sealant to prevent recurrent epithelial ingrowth in the setting of a LASIK flap buttonhole

Cited by 4 publications

References 29 publications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Tissue Adhesives for the Management of Corneal Perforations and Challenging Corneal Conditions

Epithelial implantation treatment after small-incision lenticule extraction

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