Hydrogel swelling behavior and its biomedical applications

Holback, H.; Yoon, Yoo‐Seok; Park, K.

doi:10.1533/9780857091383.1.3

Cited by 86 publications

(65 citation statements)

References 63 publications

(188 reference statements)

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“…However, the mechanism and impact of shrinking‐swelling cycles are still unclear. In general, hydrogels can undergo reversible changes, but repeated cycles can alter their original state . In this study, no significant differences ( P > 0.05, normality Student t test) were observed between the PEG‐CH‐K and xerogels without ketoprofen (Table ).…”

Section: Resultsmentioning

confidence: 50%

“…In general, hydrogels can undergo reversible changes, but repeated cycles can alter their original state. 49 In this study, no significant differences (P > 0.05, normality Student t test) were observed between the PEG-CH-K and xerogels without ketoprofen (Table II). However, a significant difference (P < 0.05) was observed in the maximum swelling of the newly photopolymerized hydrogels compared with the samples that underwent one dry cycle process.…”

Section: Swelling Behavior and Ketoprofen Release Profile Of Polymer mentioning

confidence: 49%

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Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Gaitán-Tolosa

Montiel-Campos

Flores-Estrada

et al. 2018

J of Applied Polymer Sci

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Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti‐inflammatory drug with short half‐life (<2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi‐interpenetrated network of poly(ethylene glycol)‐chitosan. The pore size studied by small‐angle X‐ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 ± 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 ± 0.03 mg/mL, 8 h) and half of the doses up to 24 h. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.

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Section: Resultsmentioning

confidence: 50%

Section: Swelling Behavior and Ketoprofen Release Profile Of Polymer mentioning

confidence: 49%

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Gaitán-Tolosa

Montiel-Campos

Flores-Estrada

et al. 2018

J of Applied Polymer Sci

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“…In addition to high thermal stability, the high swelling ratio was also observed in hydrogels. The previous study stated that the network structure of the hydrogels are formed by either physical interaction or chemical interaction and the integrity and swelling of the hydrogels are depending upon the degree of cross-linking 69 . As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Johnson

Kong

Miao

et al. 2020

Sci Rep

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Periodontitis is an inflammatory disease that can lead to the periodontal pocket formation and tooth loss. This study was aimed to develop antimicrobials loaded hydrogels composed of cellulose nanofibers (CNF) and κ-carrageenan oligosaccharides (CO) nanoparticles for the treatment of periodontitis. Two antimicrobial agents such as surfactin and Herbmedotcin were selected as the therapeutic agents and the hydrogels were formulated based on the increasing concentration of surfactin. The proposed material has high thermal stability, controlled release, and water absorption capacity. This study was proceeded by investigating the in vitro antibacterial and anti-inflammatory properties of the hydrogels. This material has strong antibacterial activity against periodontal pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium nucleatum, and Pseudomonas aeruginosa. Moreover, a significant increase in malondialdehyde (MDA) production and a decrease in biofilm formation and metabolic activity of the bacteria was observed in the presence of hydrogel. Besides, it reduced the reactive oxygen species (ROS) generation, transcription factor, and cytokines production in human gingival fibroblast cells (HGF) under inflammatory conditions. In conclusion, the hydrogels were successfully developed and proven to have antibacterial and anti-inflammatory properties for the treatment of periodontitis. Thus, it can be used as an excellent candidate for periodontitis treatment.

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“…Polymers can be synthesized by various mechanisms, such as radical polymerization, condensation polymerization, graft copolymerization, photopolymerization, and ring-opening polymerization [56].…”

Section: Polymeric Nanosystemsmentioning

confidence: 99%

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

et al. 2020

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Central nervous system (CNS) disorders encompass a vast spectrum of pathological conditions and represent a growing concern worldwide. Despite the high social and clinical interest in trying to solve these pathologies, there are many challenges to bridge in order to achieve an effective therapy. One of the main obstacles to advancements in this field that has hampered many of the therapeutic strategies proposed to date is the presence of the CNS barriers that restrict the access to the brain. However, adequate brain biodistribution and neuronal cells specific accumulation in the targeted site also represent major hurdles to the attainment of a successful CNS treatment. Over the last few years, nanotechnology has taken a step forward towards the development of therapeutics in neurologic diseases and different approaches have been developed to surpass these obstacles. The versatility of the designed nanocarriers in terms of physical and chemical properties, and the possibility to functionalize them with specific moieties, have resulted in improved neurotargeted delivery profiles. With the concomitant progress in biology research, many of these strategies have been inspired by nature and have taken advantage of physiological processes to achieve brain delivery. Here, the different nanosystems and targeting moieties used to achieve a neuronal delivery reported in the open literature are comprehensively reviewed and critically discussed, with emphasis on the most recent bioinspired advances in the field. Finally, we express our view on the paramount challenges in targeted neuronal delivery that need to be overcome for these promising therapeutics to move from the bench to the bedside.

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Hydrogel swelling behavior and its biomedical applications

Cited by 86 publications

References 63 publications

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

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