Hydrogel-Transformable Antioxidant Poly-γ-Glutamic Acid/Polyethyleneimine Hemostatic Powder for Efficient Wound Hemostasis

Li, Xiang; Han, Wenli; He, Gao; Yang, Jiahao; Li, Jing; Ma, Hongxia; Wang, Shige

doi:10.3390/gels10010068

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…It is worth mentioning that extensive inflammatory infiltration represents a common feature of chronic wounds, which hinders the repair of the wound in a chronological and biological sequence [ 199 ]. In parallel, rapid and effective hemostasis is of paramount importance to improve the wound healing process [ 200 ]. As a consequence, it may be necessary to incorporate additional agents alongside antioxidants within the hydrogel structure to effectively inhibit inflammation, promote hemostasis, and promote wound healing [ 201 , 202 ].…”

Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds

Maeso,

Antezana,

Hvozda Arana

et al. 2024

Pharmaceutics

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The skin is the largest organ of the body, and it acts as a protective barrier against external factors. Chronic wounds affect millions of people worldwide and are associated with significant morbidity and reduced quality of life. One of the main factors involved in delayed wound healing is oxidative injury, which is triggered by the overproduction of reactive oxygen species. Oxidative stress has been implicated in the pathogenesis of chronic wounds, where it is known to impair wound healing by causing damage to cellular components, delaying the inflammatory phase of healing, and inhibiting the formation of new blood vessels. Thereby, the treatment of chronic wounds requires a multidisciplinary approach that addresses the underlying causes of the wound, provides optimal wound care, and promotes wound healing. Among the promising approaches to taking care of chronic wounds, antioxidants are gaining interest since they offer multiple benefits related to skin health. Therefore, in this review, we will highlight the latest advances in the use of natural polymers with antioxidants to generate tissue regeneration microenvironments for skin wound healing.

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Section: Concluding Remarks and Future Directionsmentioning

confidence: 99%

Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds

Maeso,

Antezana,

Hvozda Arana

et al. 2024

Pharmaceutics

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“…Polyvinyl alcohol (PVA) is a commonly used polymer for hydrogel fabrication because of its distinguished properties and excellent biocompatibility. In addition, PVA has been diversely applied to biomedical applications, such as hemostasis bandages, self-healing materials, 3D tissue scaffolds, and wound healing [ 50 , 51 , 52 , 53 ].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Antibacterial Therapy of Gallic Acid-Derived Carbon-Based Nanoparticles (GACNPs): Synthesis, Characterization, and Hydrogel Formulation

Dechsri,

Suwanchawalit,

Patrojanasophon

et al. 2024

Pharmaceutics

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Carbon-based nanoparticles (CNPs) have gained recognition because of their good biocompatibility, easy preparation, and excellent phototherapy properties. In biomedicine applications, CNPs are widely applied as photodynamic agents for antibacterial purposes. Photodynamic therapy has been considered a candidate for antibacterial agents because of its noninvasiveness and minimal side effects, especially in the improvement in antibacterial activity against multidrug-resistant bacteria, compared with conventional antibiotic medicines. Here, we developed CNPs from an active polyhydroxy phenolic compound, namely, gallic acid, which has abundant hydroxyl groups that can yield photodynamic effects. Gallic acid CNPs (GACNPs) were rapidly fabricated via a microwave-assisted technique at 200 °C for 20 min. GACNPs revealed notable antibacterial properties against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The minimum inhibitory concentrations of GACNPs in S. aureus and E. coli were equal at approximately 0.29 mg/mL and considerably lower than those in gallic acid solution. Furthermore, the GACNP-loaded hydrogel patches demonstrated an attractive photodynamic effect against S. aureus, and it was superior to that of Ag hydrofiber®, a commercial material. Therefore, the photodynamic properties of GACNPs can be potentially used in the development of antibacterial hydrogels for wound healing applications.

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“…Furthermore, PTIO • has also attracted much attention as a redox mediator for batteries [35][36][37]. Recently, it has been reported that PTIO • can be used to estimate the activity of antioxidants as a reactivity model of reactive oxygen species [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. However, there is no report on the reactivity of PTIO • in the presence of redox-inactive metal ions.…”

Section: Introductionmentioning

confidence: 99%

Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO•) in Acetonitrile and Its Regeneration Induced by Water

Shoji,

Terashima,

Ohkubo

et al. 2024

IJMS

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2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO•), a persistent nitronyl nitroxide radical, has been used for the detection and trapping of nitric oxide, as a redox mediator for batteries, for the activity estimation of antioxidants, and so on. However, there is no report on the reactivity of PTIO• in the presence of redox-inactive metal ions. In this study, it is demonstrated that the addition of scandium triflate, Sc(OTf)3 (OTf = OSO2CF3), to an acetonitrile (MeCN) solution of PTIO• resulted in an electron-transfer disproportionation to generate the corresponding cation (PTIO+) and anion (PTIO−), the latter of which is suggested to be stabilized by Sc3+ to form [(PTIO)Sc]2+. The decay of the absorption band at 361 nm due to PTIO•, monitored using a stopped-flow technique, obeyed second-order kinetics. The second-order rate constant for the disproportionation, thus determined, increased with increasing the Sc(OTf)3 concentration to reach a constant value. A drastic change in the cyclic voltammogram recorded for PTIO• in deaerated MeCN containing 0.10 M Bu4NClO4 was also observed upon addition of Sc(OTf)3, suggesting that the large positive shift of the one-electron reduction potential of PTIO• (equivalent to the one-electron oxidation potential of PTIO−) in the presence of Sc(OTf)3 may result in the disproportionation. When H2O was added to the PTIO•–Sc(OTf)3 system in deaerated MeCN, PTIO• was completely regenerated. It is suggested that the complex formation of Sc3+ with H2O may weaken the interaction between PTIO− and Sc3+, leading to electron-transfer comproportionation to regenerate PTIO•. The reversible disproportionation of PTIO• was also confirmed by electron paramagnetic resonance (EPR) spectroscopy.

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Hydrogel-Transformable Antioxidant Poly-γ-Glutamic Acid/Polyethyleneimine Hemostatic Powder for Efficient Wound Hemostasis

Cited by 6 publications

References 37 publications

Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds

Progress in the Use of Hydrogels for Antioxidant Delivery in Skin Wounds

Photodynamic Antibacterial Therapy of Gallic Acid-Derived Carbon-Based Nanoparticles (GACNPs): Synthesis, Characterization, and Hydrogel Formulation

Scandium Ion-Promoted Electron-Transfer Disproportionation of 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO•) in Acetonitrile and Its Regeneration Induced by Water

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